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    CCNC cyclin C [ Homo sapiens (human) ]

    Gene ID: 892, updated on 3-May-2024

    Summary

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    Official Symbol
    CCNCprovided by HGNC
    Official Full Name
    cyclin Cprovided by HGNC
    Primary source
    HGNC:HGNC:1581
    See related
    Ensembl:ENSG00000112237 MIM:123838; AllianceGenome:HGNC:1581
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CycC; SRB11; hSRB11
    Summary
    The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 29.5), gall bladder (RPKM 20.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CCNC in Genome Data Viewer
    Location:
    6q16.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (99542387..99568814, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (100716675..100743083, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (99990263..100016690, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene thiosulfate sulfurtransferase like domain containing 3 Neighboring gene ubiquitin specific peptidase 45 Neighboring gene NANOG hESC enhancer GRCh37_chr6:99904596-99905315 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17417 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:99962307-99963214 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:99963215-99964120 Neighboring gene uncharacterized LOC124901365 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24857 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24859 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24862 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:100023517-100023714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24863 Neighboring gene ribosomal protein S3 pseudogene 5 Neighboring gene CCNC and PRDM13 intergenic region DNase I hypersensitve site DHS6S1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:100051429-100052268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:100061850-100062398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17423 Neighboring gene PR/SET domain 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide CRISPR screens reveal cyclin C as synthetic survival target of BRCA2. Tang M, et al. Nucleic Acids Res, 2021 Jul 21. PMID 34197614, Free PMC Article
    2. Cyclin C regulates human hematopoietic stem/progenitor cell quiescence. Miyata Y, et al. Stem Cells, 2010 Feb. PMID 19967789, Free PMC Article
    3. Cell cycle regulatory effects of retinoic Acid and forskolin are mediated by the cyclin C gene. Makkonen KM, et al. J Mol Biol, 2009 Oct 23. PMID 19683536
    4. Two isoforms of the human cyclin C gene are expressed differentially suggesting that they may have distinct functions. Katona RL, et al. Acta Biol Hung, 2007 Mar. PMID 17385550
    5. Highly frequent allelic loss of chromosome 6q16-23 in osteosarcoma: involvement of cyclin C in osteosarcoma. Ohata N, et al. Int J Mol Med, 2006 Dec. PMID 17089020

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress.
      Title: Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress.
    2. Genome-wide CRISPR screens reveal cyclin C as synthetic survival target of BRCA2.
      Title: Genome-wide CRISPR screens reveal cyclin C as synthetic survival target of BRCA2.
    3. cyclin C binding stimulates the reduction of low-GTPase activity Drp1 oligomers into dimers capable of producing high-GTPase activity filaments.
      Title: Cyclin C directly stimulates Drp1 GTP affinity to mediate stress-induced mitochondrial hyperfission.
    4. Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.
      Title: Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.
    5. our results suggest that mTORC1 activation in NAFLD and insulin resistance results in down-regulation of the CDK8-CycC complex and elevation of lipogenic protein expression.
      Title: mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC).
    6. results suggest that CCNC temporarily protects SRC-2 against degradation and this event is involved in the transcriptional regulation of SRC-2 cell cycle target genes.
      Title: Cyclin C interacts with steroid receptor coactivator 2 and upregulates cell cycle genes in MCF-7 cells.
    7. Cancer-mediated CDK8 point mutations (D173A and D189N) change the binding pattern of cdk8 to its partner, CycC.
      Title: All-atomic molecular dynamic studies of human CDK8: insight into the A-loop, point mutations and binding with its partner CycC.
    8. cyclin-C-CDK complexes phosphorylate the Notch1 intracellular domain (ICN1) and promote ICN1 degradation
      Title: Cyclin C is a haploinsufficient tumour suppressor.
    9. analysis of the structure-kinetic relationship of the cyclin-dependent kinase 8 (CDK8)/cyclin C (CycC) complex
      Title: Structure-kinetic relationship study of CDK8/CycC specific compounds.
    10. Silencing beta-catenin gene may induce changes of cell cycle and in cyclin B1 and cyclin C protein expression.
      Title: The effect of cell cycle and expression of cyclin B1 and cyclin C protein in hepatocellular carcinoma cell line HepG2 and SMMC-7721 after of silencing β-catenin gene.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme, which includes cyclin c, during Tat-mediated transactivation of the HIV-1 LTR PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G0 to G1 transition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CKM complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of CKM complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-C
    Names
    SRB11 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013399.2 → NP_001013417.1  cyclin-C isoform b

      See identical proteins and their annotated locations for NP_001013417.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site compared to variant 1, that results in the use of a downstream translational start codon. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      BC056153, BM788717
      Consensus CDS
      CCDS47461.1
      UniProtKB/TrEMBL
      E5RFX8
      Related
      ENSP00000430014.1, ENST00000523799.5
      Conserved Domains (2) summary
      cd20514
      Location:69 → 160
      CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins
      cl40454
      Location:1 → 61
      CYCLIN_SF; Cyclin box fold superfamily

    2. NM_001363537.2 → NP_001350466.1  cyclin-C isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AL137784
      Consensus CDS
      CCDS87420.1
      UniProtKB/TrEMBL
      E5RFK5, H0YBQ5
      Related
      ENSP00000430381.1, ENST00000520371.5
      Conserved Domains (2) summary
      cd20513
      Location:40 → 146
      CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
      cd20514
      Location:154 → 245
      CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins

    3. NM_005190.4 → NP_005181.2  cyclin-C isoform a

      See identical proteins and their annotated locations for NP_005181.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      BC041123, BC056153
      Consensus CDS
      CCDS34502.1
      UniProtKB/Swiss-Prot
      B4DPZ1, P24863, Q9H543
      UniProtKB/TrEMBL
      Q7Z4L3
      Related
      ENSP00000428982.1, ENST00000520429.6
      Conserved Domains (2) summary
      cd20513
      Location:40 → 146
      CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
      cd20514
      Location:154 → 245
      CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      99542387..99568814 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419485.1 → XP_047275441.1  cyclin-C isoform X2

    2. XM_047419489.1 → XP_047275445.1  cyclin-C isoform X5

      Related
      ENSP00000427885.1, ENST00000524049.5

    3. XM_047419484.1 → XP_047275440.1  cyclin-C isoform X1

      UniProtKB/TrEMBL
      E5RFK5
      Related
      ENSP00000430294.1, ENST00000518714.5

    4. XM_047419486.1 → XP_047275442.1  cyclin-C isoform X3

    5. XM_047419487.1 → XP_047275443.1  cyclin-C isoform X4

      UniProtKB/TrEMBL
      G5E954
      Related
      ENSP00000487040.1, ENST00000627680.2

    6. XM_011536232.4 → XP_011534534.1  cyclin-C isoform X6

      Conserved Domains (1) summary
      cd00043
      Location:48 → 143
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    7. XM_017011436.3 → XP_016866925.1  cyclin-C isoform X7

      UniProtKB/TrEMBL
      Q5JV82

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      100716675..100743083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356692.1 → XP_054212667.1  cyclin-C isoform X2

    2. XM_054356695.1 → XP_054212670.1  cyclin-C isoform X5

    3. XM_054356693.1 → XP_054212668.1  cyclin-C isoform X3

    4. XM_054356691.1 → XP_054212666.1  cyclin-C isoform X1

      UniProtKB/TrEMBL
      E5RFK5

    5. XM_054356694.1 → XP_054212669.1  cyclin-C isoform X4

      UniProtKB/TrEMBL
      G5E954

    6. XM_054356697.1 → XP_054212672.1  cyclin-C isoform X7

    7. XM_054356696.1 → XP_054212671.1  cyclin-C isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24863.2 GenPept UniProtKB/Swiss-Prot:P24863

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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