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    KCNK2 potassium two pore domain channel subfamily K member 2 [ Homo sapiens (human) ]

    Gene ID: 3776, updated on 5-Mar-2024

    Summary

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    Official Symbol
    KCNK2provided by HGNC
    Official Full Name
    potassium two pore domain channel subfamily K member 2provided by HGNC
    Primary source
    HGNC:HGNC:6277
    See related
    Ensembl:ENSG00000082482 MIM:603219; AllianceGenome:HGNC:6277
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TREK; TPKC1; TREK1; K2p2.1; TREK-1; hTREK-1c; hTREK-1e
    Summary
    This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in adrenal (RPKM 18.5), thyroid (RPKM 2.6) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See KCNK2 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (215005542..215237090)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (214245543..214477417)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (215178885..215410433)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 24 Neighboring gene uncharacterized LOC124904510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2534 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:215228700-215229418 Neighboring gene uncharacterized LOC124904511 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:215256438-215256960 Neighboring gene NANOG hESC enhancer GRCh37_chr1:215325097-215325634 Neighboring gene voltage dependent anion channel 1 pseudogene 10 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:215588487-215589150 Neighboring gene uncharacterized LOC124904598

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Involvement of TREK1 channels in the proliferation of human hepatic stellate LX-2 cells. Kondo R, et al. J Pharmacol Sci, 2022 Mar. PMID 35177207
    2. Intracellular activation of full-length human TREK-1 channel by hypoxia, high lactate, and low pH denotes polymodal integration by ischemic factors. Mukherjee S, et al. Pflugers Arch, 2021 Feb. PMID 33025137
    3. A regulatory domain in the K(2P)2.1 (TREK-1) carboxyl-terminal allows for channel activation by monoterpenes. Arazi E, et al. Mol Cell Neurosci, 2020 Jun. PMID 32320829
    4. Involvement of the TREK-1 channel in human alveolar cell membrane potential and its regulation by inhibitors of the chloride current. Canella R, et al. J Cell Physiol, 2019 Aug. PMID 30805940
    5. Triple arginine residues in the proximal C-terminus of TREK K(+) channels are critical for biphasic regulation by phosphatidylinositol 4,5-bisphosphate. Woo J, et al. Am J Physiol Cell Physiol, 2019 Mar 1. PMID 30576235

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prolonged stretching of rat uteri causes hypoxia and inhibits contractility via potassium channel TREK1.
      Title: Prolonged stretching of rat uteri causes hypoxia and inhibits contractility via potassium channel TREK1.
    2. miR-132-3p promotes heat stimulation-induced esophageal squamous cell carcinoma tumorigenesis by targeting KCNK2.
      Title: miR-132-3p promotes heat stimulation-induced esophageal squamous cell carcinoma tumorigenesis by targeting KCNK2.
    3. High glucose induced HIF-1alpha/TREK1 expression and myometrium relaxation during pregnancy.
      Title: High glucose induced HIF-1α/TREK1 expression and myometrium relaxation during pregnancy.
    4. Activation of TREK-1 (K2P2.1) potassium channels protects against influenza A-induced lung injury.
      Title: Activation of TREK-1 (K(2P)2.1) potassium channels protects against influenza A-induced lung injury.
    5. Involvement of TREK1 channels in the proliferation of human hepatic stellate LX-2 cells.
      Title: Involvement of TREK1 channels in the proliferation of human hepatic stellate LX-2 cells.
    6. Intracellular activation of full-length human TREK-1 channel by hypoxia, high lactate, and low pH denotes polymodal integration by ischemic factors.
      Title: Intracellular activation of full-length human TREK-1 channel by hypoxia, high lactate, and low pH denotes polymodal integration by ischemic factors.
    7. Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH.
      Title: Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH.
    8. A regulatory domain in the K2P2.1 (TREK-1) carboxyl-terminal allows for channel activation by monoterpenes.
      Title: A regulatory domain in the K(2P)2.1 (TREK-1) carboxyl-terminal allows for channel activation by monoterpenes.
    9. Astrocytic AEG-1 regulates expression of TREK-1 under acute hypoxia.
      Title: Astrocytic AEG-1 regulates expression of TREK-1 under acute hypoxia.
    10. The activity of TREK-1 has a key role for the correct functioning of the alveolar epithelium.
      Title: Involvement of the TREK-1 channel in human alveolar cell membrane potential and its regulation by inhibitors of the chloride current.
    Submit: New GeneRIF Correction See all GeneRIFs (76)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC126742, MGC126744

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables outward rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium ion leak channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cardiac ventricle development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cochlea development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in memory IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cardiac muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to axon injury IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stabilization of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in astrocyte projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in calyx of Held IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    potassium channel subfamily K member 2
    Names
    K2P2.1 potassium channel
    TREK-1 K(+) channel subunit
    TWIK-related potassium channel 1
    outward rectifying potassium channel protein TREK-1
    potassium channel, two pore domain subfamily K, member 2
    potassium inwardly-rectifying channel, subfamily K, member 2
    tandem-pore-domain potassium channel TREK-1
    two pore domain potassium channel TREK-1
    two pore potassium channel TPKC1
    two-pore potassium channel 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017424.3 → NP_001017424.1  potassium channel subfamily K member 2 isoform a

      See identical proteins and their annotated locations for NP_001017424.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC092804, AK123409, AL583830, AU280191, BC069462, CD625291, CD625297, DA475072
      Consensus CDS
      CCDS41466.1
      UniProtKB/TrEMBL
      U3N834
      Related
      ENSP00000375765.2, ENST00000391895.6
      Conserved Domains (1) summary
      pfam07885
      Location:137 → 192
      Ion_trans_2; Ion channel

    2. NM_001017425.3 → NP_001017425.2  potassium channel subfamily K member 2 isoform c

      See identical proteins and their annotated locations for NP_001017425.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and beginning of the coding region compared to variant 1. The resulting isoform (c) is slightly shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC092804, AC099675, AK123409, BC069462, DR001358, EF165334
      Consensus CDS
      CCDS41467.1
      UniProtKB/Swiss-Prot
      A1Z1V3, A8K618, B2RCS4, B7ZL56, D3DTA5, O95069, Q5DP47, Q5DP48, Q9NRT2, Q9UNE3
      Related
      ENSP00000394033.2, ENST00000444842.7
      Conserved Domains (1) summary
      pfam07885
      Location:142 → 196
      Ion_trans_2; Ion channel

    3. NM_014217.4 → NP_055032.1  potassium channel subfamily K member 2 isoform b

      See identical proteins and their annotated locations for NP_055032.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and beginning of the open reading frame compared to variant 1. The resulting isoform (b) is slightly shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC092804, AC099675, AK123409, BC069462, BC101693, DR001358
      Consensus CDS
      CCDS31024.1
      UniProtKB/TrEMBL
      U3N6F0
      Related
      ENSP00000375764.2, ENST00000391894.6
      Conserved Domains (1) summary
      pfam07885
      Location:127 → 181
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      215005542..215237090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001249.2 → XP_016856738.1  potassium channel subfamily K member 2 isoform X1

      Conserved Domains (1) summary
      pfam07885
      Location:127 → 182
      Ion_trans_2; Ion channel

    2. XM_011509524.3 → XP_011507826.1  potassium channel subfamily K member 2 isoform X2

      See identical proteins and their annotated locations for XP_011507826.1

      Conserved Domains (1) summary
      pfam07885
      Location:86 → 140
      Ion_trans_2; Ion channel

    3. XM_011509522.3 → XP_011507824.1  potassium channel subfamily K member 2 isoform X2

      See identical proteins and their annotated locations for XP_011507824.1

      Conserved Domains (1) summary
      pfam07885
      Location:86 → 140
      Ion_trans_2; Ion channel

    4. XM_047419881.1 → XP_047275837.1  potassium channel subfamily K member 2 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      214245543..214477417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336482.1 → XP_054192457.1  potassium channel subfamily K member 2 isoform X1

    2. XM_054336483.1 → XP_054192458.1  potassium channel subfamily K member 2 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95069.2 GenPept UniProtKB/Swiss-Prot:O95069

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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