shu shutdown [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: shuprovided by FlyBase
Official Full Name: shutdownprovided by FlyBase
Primary source: FLYBASE:FBgn0003401
Locus tag: Dmel_CG4735
See related: AllianceGenome:FB:FBgn0003401
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4735; Dmel\CG4735; Shu
Summary: Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Involved in oogenesis and piRNA metabolic process. Located in P granule and Yb body. Is expressed in several structures, including germline cell and gonad. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human FKBP6 (FKBP prolyl isomerase family member 6 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (23841461..23843286, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19728984..19730809, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables Hsp90 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in oogenesis	HMP more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in piRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in primary piRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrotransposon silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in secondary piRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in Yb body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

NP_611837.1

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The following sections contain reference sequences that belong to a specific genome build. Explain