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    Agap1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 [ Mus musculus (house mouse) ]

    Gene ID: 347722, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Agap1provided by MGI
    Official Full Name
    ArfGAP with GTPase domain, ankyrin repeat and PH domain 1provided by MGI
    Primary source
    MGI:MGI:2653690
    See related
    Ensembl:ENSMUSG00000055013 AllianceGenome:MGI:2653690
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ggap1; Centg2; mKIAA1099
    Summary
    Predicted to enable GTPase activity and phospholipid binding activity. Predicted to act upstream of or within protein transport. Predicted to be located in cytosol. Predicted to be active in nucleus. Is expressed in central nervous system; peripheral nervous system ganglion; sensory organ; tooth; and vibrissa. Orthologous to several human genes including AGAP1 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 13.5), cerebellum adult (RPKM 12.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Agap1 in Genome Data Viewer
    Location:
    1 D; 1 45.06 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (89382533..89823004)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (89454811..89895282)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A pseudogene Neighboring gene RIKEN cDNA C030007H22 gene Neighboring gene predicted gene, 41913 Neighboring gene STARR-seq mESC enhancer starr_01663 Neighboring gene STARR-seq mESC enhancer starr_01664 Neighboring gene predicted gene, 41914 Neighboring gene RIKEN cDNA 4933400F21 gene Neighboring gene STARR-seq mESC enhancer starr_01667 Neighboring gene STARR-seq mESC enhancer starr_01669 Neighboring gene STARR-seq mESC enhancer starr_01670 Neighboring gene uncharacterized LOC102637806 Neighboring gene STARR-seq mESC enhancer starr_01674 Neighboring gene gastrulation brain homeobox 2 Neighboring gene predicted gene, 41915 Neighboring gene ankyrin repeat and SOCS box-containing 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release. Bendor J, et al. EMBO J, 2010 Aug 18. PMID 20664521, Free PMC Article
    2. GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins. Xia C, et al. Mol Cell Biol, 2003 Apr. PMID 12640130, Free PMC Article
    3. The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin. Arnold M, et al. Front Cell Neurosci, 2016. PMID 27713690, Free PMC Article
    4. AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase. Meurer S, et al. J Biol Chem, 2004 Nov 19. PMID 15381706
    5. GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity. Luo R, et al. J Biol Chem, 2012 May 18. PMID 22453919, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.
      Title: GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.
    2. The elimination of adaptor protein 3 or abrogation of AGAP1-M5 muscarinic receptor interaction in vivo decreased the magnitude of presynaptic M5 muscarinic receptor mediated dopamine release potentiation in the striatum.
      Title: AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.
    3. AGAP1 is a novel binding partner of nitric oxide-sensitive guanylyl cyclase
      Title: AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1
    Names
    AGAP-1
    centaurin-gamma-2
    cnt-g2
    NP_001032213.1
    NP_835220.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037136.1 → NP_001032213.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC124227, AK046523, AK147503
      Consensus CDS
      CCDS15148.1
      UniProtKB/TrEMBL
      A0A087WRF2, Q3UH88
      Related
      ENSMUSP00000140599.2, ENSMUST00000190096.7
      Conserved Domains (8) summary
      cd04103
      Location:72 → 229
      Centaurin_gamma; Centaurin gamma (CENTG) GTPase
      smart00173
      Location:73 → 235
      RAS; Ras subfamily of RAS small GTPases
      cd00204
      Location:683 → 772
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01250
      Location:344 → 539
      PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
      pfam00169
      Location:347 → 411
      PH; PH domain
      pfam01412
      Location:558 → 672
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:683 → 773
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:715 → 746
      ANK; ANK repeat [structural motif]

    2. NM_178119.3 → NP_835220.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_835220.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AC124227, AK046523, AK147503
      Consensus CDS
      CCDS15149.1
      UniProtKB/Swiss-Prot
      Q3UHA0, Q6ZPX9, Q8BXK8, Q8BZG0
      Related
      ENSMUSP00000027521.9, ENSMUST00000027521.15
      Conserved Domains (8) summary
      cd04103
      Location:72 → 229
      Centaurin_gamma; Centaurin gamma (CENTG) GTPase
      smart00173
      Location:73 → 235
      RAS; Ras subfamily of RAS small GTPases
      cd00204
      Location:736 → 825
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01250
      Location:344 → 592
      PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
      pfam00169
      Location:347 → 411
      PH; PH domain
      pfam01412
      Location:611 → 725
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:736 → 826
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:768 → 799
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      89382533..89823004
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BXK8.1 GenPept UniProtKB/Swiss-Prot:Q8BXK8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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