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    pabp-2 RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172768, updated on 5-May-2024

    Summary

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    Gene symbol
    pabp-2
    Gene description
    RRM domain-containing protein
    Primary source
    WormBase:WBGene00003904
    Locus tag
    CELE_C17E4.5
    See related
    AllianceGenome:WB:WBGene00003904
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Is expressed in intestine and nervous system. Human ortholog(s) of this gene implicated in oculopharyngeal muscular dystrophy. Orthologous to several human genes including PABPN1 (poly(A) binding protein nuclear 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See pabp-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (9420912..9421992, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RING-CH-type domain-containing protein Neighboring gene Methyltransferase domain-containing protein Neighboring gene ABC2_membrane domain-containing protein Neighboring gene Vacuolar protein sorting-associated protein 72 homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The type II poly(A)-binding protein PABP-2 genetically interacts with the let-7 miRNA and elicits heterochronic phenotypes in Caenorhabditis elegans. Hurschler BA, et al. Nucleic Acids Res, 2011 Jul. PMID 21415013, Free PMC Article
    2. LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decay. Mattout A, et al. Nat Cell Biol, 2020 May. PMID 32251399, Free PMC Article
    3. MEX-3 interacting proteins link cell polarity to asymmetric gene expression in Caenorhabditis elegans. Huang NN, et al. Development, 2002 Feb. PMID 11830574
    4. High-throughput in vivo analysis of gene expression in Caenorhabditis elegans. Hunt-Newbury R, et al. PLoS Biol, 2007 Sep. PMID 17850180, Free PMC Article
    5. Mechanism and regulation of translation in C. elegans. Rhoads RE, et al. WormBook, 2006 Jan 28. PMID 18050488, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Depletion of PABP-2 by RNA interference suppresses loss of let-7 activity, and, in let-7 wild-type animals, leads to precocious differentiation of seam cells.
      Title: The type II poly(A)-binding protein PABP-2 genetically interacts with the let-7 miRNA and elicits heterochronic phenotypes in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RRM domain-containing protein
    NP_492504.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9420912..9421992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060103.8 → NP_492504.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492504.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93233
      Conserved Domains (1) summary
      cl17169
      Location:79 → 154
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version

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