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    uncp-18 Syntaxin-binding protein 1 [ Caenorhabditis elegans ]

    Gene ID: 176862, updated on 23-May-2024

    Summary

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    Gene symbol
    uncp-18
    Gene description
    Syntaxin-binding protein 1
    Primary source
    WormBase:WBGene00020298
    Locus tag
    CELE_T07A9.10
    See related
    AllianceGenome:WB:WBGene00020298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable syntaxin binding activity. Predicted to be involved in intracellular protein transport; neurotransmitter secretion; and vesicle docking involved in exocytosis. Predicted to be located in presynapse. Predicted to be active in plasma membrane and secretory granule. Orthologous to human STXBP3 (syntaxin binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See uncp-18 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (390560..393158)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Small ribosomal subunit protein eS24 Neighboring gene Sjogren's Syndrome Nuclear Autoantigen Neighboring gene Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial Neighboring gene Cytochrome c oxidase assembly protein COX14 Neighboring gene Nucleolar GTP-binding protein 1 Neighboring gene Ribosomal RNA-processing protein 8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotransmitter secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle docking involved in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Syntaxin-binding protein 1
    NP_499918.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      390560..393158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067517.7 → NP_499918.1  Syntaxin-binding protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499918.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44412
      Conserved Domains (1) summary
      pfam00995
      Location:31 → 547
      Sec1; Sec1 family
    Nucleotide Protein
    Heading Accession and Version

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