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    atl-1 Serine/threonine-protein kinase ATR [ Caenorhabditis elegans ]

    Gene ID: 179352, updated on 23-May-2024

    Summary

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    Gene symbol
    atl-1
    Gene description
    Serine/threonine-protein kinase ATR
    Primary source
    WormBase:WBGene00000226
    Locus tag
    CELE_T06E4.3
    See related
    AllianceGenome:WB:WBGene00000226
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 1-phosphatidylinositol-3-kinase activity and protein serine/threonine kinase activity. Involved in DNA damage checkpoint signaling; embryo development; and meiotic chromosome segregation. Located in nucleus. Is expressed in gonad. Human ortholog(s) of this gene implicated in Seckel syndrome 1; adenoid cystic carcinoma; colon cancer; lung cancer; and pancreatic cancer. Orthologous to human ATR (ATR serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See atl-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    18
    Sequence:
    Chromosome: V; NC_003283.11 (9634861..9645474, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene HoloCentric chromosome binding Protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stress-Induced Sleep After Exposure to Ultraviolet Light Is Promoted by p53 in Caenorhabditis elegans. DeBardeleben HK, et al. Genetics, 2017 Oct. PMID 28754659, Free PMC Article
    2. Modeling of autosomal-dominant retinitis pigmentosa in Caenorhabditis elegans uncovers a nexus between global impaired functioning of certain splicing factors and cell type-specific apoptosis. Rubio-Peña K, et al. RNA, 2015 Dec. PMID 26490224, Free PMC Article
    3. Caenorhabditis elegans ATR checkpoint kinase ATL-1 influences life span through mitochondrial maintenance. Suetomi K, et al. Mitochondrion, 2013 Nov. PMID 23434802
    4. ATM and ATR Influence Meiotic Crossover Formation Through Antagonistic and Overlapping Functions in Caenorhabditis elegans. Li W, et al. Genetics, 2019 Jun. PMID 31015193, Free PMC Article
    5. CRL2(LRR-1) E3-ligase regulates proliferation and progression through meiosis in the Caenorhabditis elegans germline. Burger J, et al. PLoS Genet, 2013 Mar. PMID 23555289, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data suggest a model in which ATM-1 and ATL-1 have antagonistic roles in very early repair processing, but are redundantly required for accumulation of the RAD-51 recombinase at DSB sites.
      Title: ATM and ATR Influence Meiotic Crossover Formation Through Antagonistic and Overlapping Functions in Caenorhabditis elegans.
    2. ATL-1 functions to maintain mtDNA independently of ribonucleotide reductase
      Title: Maintenance of mitochondrial DNA by the Caenorhabditis elegans ATR checkpoint protein ATL-1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in condensed nuclear chromosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Serine/threonine-protein kinase ATR
    NP_001256128.1
    • Confirmed by transcript evidence
    NP_505487.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9634861..9645474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073086.6 → NP_505487.3  Serine/threonine-protein kinase ATR [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505487.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22258, Q9Y061
      Conserved Domains (3) summary
      cd05164
      Location:2189 → 2458
      PIKKc; Catalytic domain of Phosphoinositide 3-kinase-related protein kinases
      pfam02259
      Location:1627 → 1873
      FAT; FAT domain
      pfam02260
      Location:2500 → 2529
      FATC; FATC domain

    2. NM_001269199.3 → NP_001256128.1  Serine/threonine-protein kinase ATR [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256128.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E5QCG9
      Conserved Domains (3) summary
      cd05164
      Location:715 → 984
      PIKKc; Catalytic domain of Phosphoinositide 3-kinase-related protein kinases
      pfam02259
      Location:153 → 399
      FAT; FAT domain
      pfam02260
      Location:1026 → 1055
      FATC; FATC domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22258.2

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