hrpa-1 Heterogeneous nuclear ribonucleoprotein A1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: hrpa-1
Gene description: Heterogeneous nuclear ribonucleoprotein A1
Primary source: WormBase:WBGene00001999
Locus tag: CELE_F42A6.7
See related: AllianceGenome:WB:WBGene00001999
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable mRNA binding activity. Involved in hemidesmosome assembly. Located in chromosome, telomeric region. Is expressed in several structures, including germ line. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 20; inclusion body myopathy with Paget disease of bone and frontotemporal dementia; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3; and tropical spastic paraparesis. Orthologous to several human genes including HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1); HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1); and HNRNPA3 (heterogeneous nuclear ribonucleoprotein A3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See hrpa-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 4

Sequence:: Chromosome: IV; NC_003282.8 (3336920..3338863, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F42A6.7 (e-PCR)
- UniSTS:313139

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in hemidesmosome assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Heterogeneous nuclear ribonucleoprotein A1

NP_001040945.1

Confirmed by transcript evidence

NP_001367846.1

Partially confirmed by transcript evidence

NP_001370723.1

Confirmed by transcript evidence

NP_001379954.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

3336920..3338863 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001380140.2 → NP_001367846.1 Heterogeneous nuclear ribonucleoprotein A1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

cd12328
Location:77 → 149

RRM2_hnRNPA_like; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A subfamily

cl17169
Location:1 → 63

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001392280.1 → NP_001379954.1 Heterogeneous nuclear ribonucleoprotein A1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

cd12328
Location:77 → 149

RRM2_hnRNPA_like; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A subfamily

cl17169
Location:1 → 63

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001383064.2 → NP_001370723.1 Heterogeneous nuclear ribonucleoprotein A1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22037, Q336L3, Q336L4, Q95X69

Conserved Domains (2) summary

cd12328
Location:115 → 187

RRM2_hnRNPA_like; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A subfamily

cl17169
Location:24 → 101

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001047480.6 → NP_001040945.1 Heterogeneous nuclear ribonucleoprotein A1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040945.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22037

Conserved Domains (2) summary

cd12328
Location:115 → 187

RRM2_hnRNPA_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A subfamily

cd12578
Location:24 → 101

RRM1_hnRNPA_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A subfamily