tag-68 Mothers against decapentaplegic homolog [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: tag-68
Gene description: Mothers against decapentaplegic homolog
Locus tag: CELE_F37D6.6
See related: AllianceGenome:WB:WBGene00006445
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable I-SMAD binding activity and transcription regulator inhibitor activity. Predicted to be involved in several processes, including cell differentiation; regulation of transcription by RNA polymerase II; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Is expressed in head neurons; intestine; and ventral nerve cord. Human ortholog(s) of this gene implicated in aortic valve disease 2; colorectal cancer; craniosynostosis; pancreatic adenocarcinoma; and radioulnar synostosis. Orthologous to human SMAD6 (SMAD family member 6) and SMAD7 (SMAD family member 7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See tag-68 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 9

Sequence:: Chromosome: I; NC_003279.8 (10501585..10505949)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F37D6.6 (e-PCR)
- UniSTS:320534

F37D6.7 (e-PCR)
- UniSTS:320065

F59C6.10 (e-PCR)
- UniSTS:316872

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables I-SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription regulator inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in SMAD protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-embryonic development	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of developmental process	IEA Inferred from Electronic Annotation more info
involved_in regulation of multicellular organismal process	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of heteromeric SMAD protein complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Mothers against decapentaplegic homolog

NP_492746.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10501585..10505949

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060345.4 → NP_492746.2 Mothers against decapentaplegic homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492746.2

Status: REVIEWED

UniProtKB/TrEMBL

G5EDS9

Conserved Domains (2) summary

cd10489
Location:14 → 152

MH1_SMAD_6_7; N-terminal Mad Homology 1 (MH1) domain in SMAD6 and SMAD7

cl00056
Location:251 → 415

MH2; C-terminal Mad Homology 2 (MH2) domain