cnb-1 EF-hand domain-containing protein;Protein phosphatase 2B regulatory subunit cnb-1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: cnb-1
Gene description: EF-hand domain-containing protein;Protein phosphatase 2B regulatory subunit cnb-1
Locus tag: CELE_F55C10.1
See related: AllianceGenome:WB:WBGene00000554
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables calcium ion binding activity. Predicted to be involved in endocytosis and regulation of catalytic activity. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Is expressed in several structures, including body wall musculature; hypodermis; intestine; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in Alzheimer's disease and dilated cardiomyopathy. Orthologous to several human genes including PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See cnb-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 7

Sequence:: Chromosome: V; NC_003283.11 (11375742..11378006)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Calcineurin regulates specific sets of endocytic processes in nematode.
Title: Calcineurin may regulate multiple endocytic processes in C. elegans.
Autophagy genes are required for the life-span regulation in calcineurin defective C. elegans strains.
Title: Autophagy genes mediate the effect of calcineurin on life span in C. elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F55C10.1 (e-PCR)
- UniSTS:314471

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein serine/threonine phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein serine/threonine phosphatase regulator activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcineurin-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of calcineurin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	HDA more info	PubMed
located_in sarcomere	HDA more info	PubMed
located_in striated muscle dense body	HDA more info	PubMed

General protein information

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Preferred Names: EF-hand domain-containing protein;Protein phosphatase 2B regulatory subunit cnb-1

NP_001256317.1

Confirmed by transcript evidence

NP_001256318.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

11375742..11378006

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001269388.2 → NP_001256317.1 EF-hand domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256317.1

Status: REVIEWED

UniProtKB/TrEMBL

H9G2Y1

Conserved Domains (2) summary

PTZ00184
Location:11 → 154

PTZ00184; calmodulin; Provisional

cd00051
Location:91 → 157

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_001269389.2 → NP_001256318.1 Protein phosphatase 2B regulatory subunit cnb-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256318.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EDN6

Conserved Domains (1) summary

COG5126
Location:13 → 161

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]