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    Tnip1 TNFAIP3 interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363599, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Tnip1provided by RGD
    Official Full Name
    TNFAIP3 interacting protein 1provided by RGD
    Primary source
    RGD:1309380
    See related
    Ensembl:ENSRNOG00000010370 AllianceGenome:RGD:1309380
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity; mitogen-activated protein kinase binding activity; and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; negative regulation of intracellular signal transduction; and positive regulation of nitrogen compound metabolic process. Predicted to be located in cytosol and nucleoplasm. Orthologous to human TNIP1 (TNFAIP3 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 289.7), Lung (RPKM 217.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tnip1 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (39537759..39585038, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (39037048..39084328, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (40255776..40303092, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene histidine triad nucleotide binding protein 1 Neighboring gene glutathione peroxidase 3 Neighboring gene 60S ribosomal protein L13-like Neighboring gene annexin A6 Neighboring gene uncharacterized LOC120095102

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response. Ashida H, et al. Nat Cell Biol, 2010 Jan. PMID 20010814, Free PMC Article
    2. A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling. Zhang S, et al. Biochem Biophys Res Commun, 2002 Sep 13. PMID 12220502
    3. Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression. Fukushi M, et al. FEBS Lett, 1999 Jan 8. PMID 9923610
    4. ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB. Mauro C, et al. J Biol Chem, 2006 Jul 7. PMID 16684768
    5. The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. Heyninck K, et al. J Cell Biol, 1999 Jun 28. PMID 10385526, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mitogen-activated protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in MyD88-dependent toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycoprotein biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TNFAIP3-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108826.1 → NP_001102296.1  TNFAIP3-interacting protein 1

      See identical proteins and their annotated locations for NP_001102296.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HEJ9, D3ZHV1
      Conserved Domains (3) summary
      cl15254
      Location:467 → 515
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      cl19219
      Location:257 → 417
      DUF342; Protein of unknown function (DUF342)
      cl19252
      Location:229 → 266
      MreC; rod shape-determining protein MreC

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      39537759..39585038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269497.1 → XP_063125567.1  TNFAIP3-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A6HEJ9, D3ZHV1

    2. XM_063269505.1 → XP_063125575.1  TNFAIP3-interacting protein 1 isoform X6

    3. XM_063269504.1 → XP_063125574.1  TNFAIP3-interacting protein 1 isoform X5

    4. XM_063269498.1 → XP_063125568.1  TNFAIP3-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A6HEJ9, D3ZHV1

    5. XM_063269503.1 → XP_063125573.1  TNFAIP3-interacting protein 1 isoform X4

    6. XM_063269501.1 → XP_063125571.1  TNFAIP3-interacting protein 1 isoform X3

    7. XM_063269499.1 → XP_063125569.1  TNFAIP3-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      A6HEJ8

    8. XM_063269496.1 → XP_063125566.1  TNFAIP3-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A6HEJ9, D3ZHV1

    9. XM_006246303.5 → XP_006246365.1  TNFAIP3-interacting protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006246365.1

      UniProtKB/TrEMBL
      A6HEJ9, D3ZHV1
      Related
      ENSRNOP00000013864.4
      Conserved Domains (3) summary
      cl15254
      Location:467 → 515
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      cl19219
      Location:257 → 417
      DUF342; Protein of unknown function (DUF342)
      cl19252
      Location:229 → 266
      MreC; rod shape-determining protein MreC

    10. XM_063269502.1 → XP_063125572.1  TNFAIP3-interacting protein 1 isoform X4

    11. XM_063269500.1 → XP_063125570.1  TNFAIP3-interacting protein 1 isoform X3

    12. XM_006246306.5 → XP_006246368.1  TNFAIP3-interacting protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006246368.1

      UniProtKB/TrEMBL
      A6HEJ8
      Conserved Domains (3) summary
      cl15254
      Location:467 → 515
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      cl19219
      Location:257 → 417
      DUF342; Protein of unknown function (DUF342)
      cl19252
      Location:229 → 266
      MreC; rod shape-determining protein MreC

    13. XM_063269506.1 → XP_063125576.1  TNFAIP3-interacting protein 1 isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version

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