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    Ankrd13d ankyrin repeat domain 13D [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361699, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ankrd13dprovided by RGD
    Official Full Name
    ankyrin repeat domain 13Dprovided by RGD
    Primary source
    RGD:1309156
    See related
    Ensembl:ENSRNOG00000028247 AllianceGenome:RGD:1309156
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309156
    Summary
    Predicted to enable ubiquitin-dependent protein binding activity. Predicted to be involved in negative regulation of receptor internalization. Predicted to be located in perinuclear region of cytoplasm and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human ANKRD13D (ankyrin repeat domain 13D). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 132.4), Thymus (RPKM 63.4) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ankrd13d in Genome Data Viewer
    Location:
    1q43
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210995012..211007430, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201565712..201577987, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219520316..219532718, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691274 Neighboring gene slingshot protein phosphatase 3 Neighboring gene G protein-coupled receptor kinase 2 Neighboring gene lysine demethylase 2A Neighboring gene small nucleolar RNA SNORA32

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane. Tanno H, et al. Mol Biol Cell, 2012 Apr. PMID 22298428, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-modified protein reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 13D
    Names
    ankyrin repeat domain 13 family, member D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108514.1 → NP_001101984.1  ankyrin repeat domain-containing protein 13D

      See identical proteins and their annotated locations for NP_001101984.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      A6HYX0, D3ZUJ7
      Related
      ENSRNOP00000025641.5, ENSRNOT00000025641.7
      Conserved Domains (3) summary
      sd00045
      Location:39 → 70
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:40 → 93
      Ank_4; Ankyrin repeats (many copies)
      pfam11904
      Location:155 → 469
      GPCR_chapero_1; GPCR-chaperone

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      210995012..211007430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230842.5 → XP_006230904.1  ankyrin repeat domain-containing protein 13D isoform X1

      Conserved Domains (1) summary
      pfam11904
      Location:90 → 404
      GPCR_chapero_1; GPCR-chaperone

    2. XM_063268220.1 → XP_063124290.1  ankyrin repeat domain-containing protein 13D isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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