U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ipo5 importin 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306182, updated on 13-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ipo5provided by RGD
    Official Full Name
    importin 5provided by RGD
    Primary source
    RGD:1308715
    See related
    Ensembl:ENSRNOG00000010989 AllianceGenome:RGD:1308715
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kpnb3; Ranbp5
    Summary
    Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in cellular response to amino acid stimulus; positive regulation of protein import into nucleus; and protein import into nucleus. Predicted to be active in cytoplasm and nucleus. Orthologous to human IPO5 (importin 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 1000.6), Muscle (RPKM 485.5) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ipo5 in Genome Data Viewer
    Location:
    15q24
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (104397626..104447985)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (97990755..98041074)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (106243110..106293326)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352981 Neighboring gene uncharacterized LOC134482024 Neighboring gene ribosomal protein S7, pseudogene 12 Neighboring gene uncharacterized LOC134482234

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3. Chao HW, et al. Nucleic Acids Res, 2012 Sep 1. PMID 22730302, Free PMC Article
    2. PGC7/Stella protects against DNA demethylation in early embryogenesis. Nakamura T, et al. Nat Cell Biol, 2007 Jan. PMID 17143267
    3. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. Jäkel S, et al. EMBO J, 1998 Aug 3. PMID 9687515, Free PMC Article
    4. Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis. Cao Z, et al. Mol Cell Proteomics, 2008 Sep. PMID 18504258, Free PMC Article
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear import signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic pattern recognition receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    importin-5
    Names
    RAN binding protein 5
    karyopherin (importin) beta 3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427143.1 → NP_001414072.1  importin-5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      D4A781

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      104397626..104447985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093991.2 → XP_038949919.1  importin-5 isoform X2

      UniProtKB/TrEMBL
      D4A781
      Conserved Domains (6) summary
      COG5215
      Location:13 → 634
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:355 → 387
      HEAT; HEAT repeat [structural motif]
      pfam13513
      Location:921 → 966
      HEAT_EZ; HEAT-like repeat
      pfam18808
      Location:268 → 357
      Importin_rep_4; Importin repeat
      pfam18816
      Location:1005 → 1051
      Importin_rep_5; Importin repeat
      pfam18829
      Location:765 → 874
      Importin_rep_6; Importin repeat 6

    2. XM_017599929.3 → XP_017455418.1  importin-5 isoform X2

      UniProtKB/TrEMBL
      D4A781
      Conserved Domains (6) summary
      COG5215
      Location:13 → 634
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:355 → 387
      HEAT; HEAT repeat [structural motif]
      pfam13513
      Location:921 → 966
      HEAT_EZ; HEAT-like repeat
      pfam18808
      Location:268 → 357
      Importin_rep_4; Importin repeat
      pfam18816
      Location:1005 → 1051
      Importin_rep_5; Importin repeat
      pfam18829
      Location:765 → 874
      Importin_rep_6; Importin repeat 6

    3. XM_224534.11 → XP_224534.8  importin-5 isoform X2

      UniProtKB/TrEMBL
      D4A781
      Conserved Domains (6) summary
      COG5215
      Location:13 → 634
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:355 → 387
      HEAT; HEAT repeat [structural motif]
      pfam13513
      Location:921 → 966
      HEAT_EZ; HEAT-like repeat
      pfam18808
      Location:268 → 357
      Importin_rep_4; Importin repeat
      pfam18816
      Location:1005 → 1051
      Importin_rep_5; Importin repeat
      pfam18829
      Location:765 → 874
      Importin_rep_6; Importin repeat 6

    4. XM_063274353.1 → XP_063130423.1  importin-5 isoform X1

    5. XM_063274354.1 → XP_063130424.1  importin-5 isoform X2

      UniProtKB/TrEMBL
      D4A781

    6. XM_063274355.1 → XP_063130425.1  importin-5 isoform X3

      UniProtKB/TrEMBL
      M0RB74
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools