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    Sntg2 syntrophin, gamma 2 [ Mus musculus (house mouse) ]

    Gene ID: 268534, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Sntg2provided by MGI
    Official Full Name
    syntrophin, gamma 2provided by MGI
    Primary source
    MGI:MGI:1919541
    See related
    Ensembl:ENSMUSG00000020672 AllianceGenome:MGI:1919541
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Syn5; G2syn; 9530013L23; 2210008K22Rik
    Summary
    Predicted to enable PDZ domain binding activity and neuroligin family protein binding activity. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of dystrophin-associated glycoprotein complex. Is expressed in gut and urinary system. Orthologous to human SNTG2 (syntrophin gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bladder adult (RPKM 13.2), colon adult (RPKM 3.0) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sntg2 in Genome Data Viewer
    Location:
    12 A2; 12 13.0 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (30224481..30423424, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (30174482..30373392, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40873 Neighboring gene predicted gene, 32084 Neighboring gene RIKEN cDNA 2310016D03 gene Neighboring gene receptor-like tyrosine kinase, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. gamma-Syntrophin scaffolding is spatially and functionally distinct from that of the alpha/beta syntrophins. Alessi A, et al. Exp Cell Res, 2006 Oct 1. PMID 16857187
    2. Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction. Chen Z, et al. J Biol Chem, 2006 May 5. PMID 16533813
    3. Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome. Lyssand JS, et al. J Biol Chem, 2008 Jul 4. PMID 18468998, Free PMC Article
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuroligin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dystrophin-associated glycoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular anatomical structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    gamma-2-syntrophin
    Names
    syntrophin-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324519.1 → NP_001311448.1  gamma-2-syntrophin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157276, AC159628
      UniProtKB/TrEMBL
      Q8BZG8
      Conserved Domains (1) summary
      cd00992
      Location:18 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    2. NM_001324520.1 → NP_001311449.1  gamma-2-syntrophin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC157276, AC159628, AK008673, AK087560, BY098098
      UniProtKB/TrEMBL
      Q8BZG8

    3. NM_001324521.1 → NP_001311450.1  gamma-2-syntrophin isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC159628, AK087560, BC058204, BY098098

    4. NM_172951.3 → NP_766539.2  gamma-2-syntrophin isoform 1

      See identical proteins and their annotated locations for NP_766539.2

      Status: VALIDATED

      Source sequence(s)
      AK035310, AK087560, BC138956, BY098098
      Consensus CDS
      CCDS25858.1
      UniProtKB/Swiss-Prot
      B2RSQ0, Q925E0
      UniProtKB/TrEMBL
      Q8BZG8
      Related
      ENSMUSP00000021004.8, ENSMUST00000021004.14
      Conserved Domains (1) summary
      cd00992
      Location:72 → 153
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RNA

    1. NR_136915.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159628, AK087560, BY098098
      Related
      ENSMUST00000142046.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      30224481..30423424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315072.2 → XP_017170561.1  gamma-2-syntrophin isoform X2

      Conserved Domains (1) summary
      cd00992
      Location:18 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    2. XM_006515108.2 → XP_006515171.1  gamma-2-syntrophin isoform X1

      UniProtKB/TrEMBL
      Q8BZG8
      Conserved Domains (1) summary
      cd00992
      Location:72 → 153
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    3. XM_011243873.1 → XP_011242175.1  gamma-2-syntrophin isoform X3

    RNA

    1. XR_872414.2 RNA Sequence

      Related
      ENSMUST00000133324.8

    2. XR_003950053.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q925E0.1 GenPept UniProtKB/Swiss-Prot:Q925E0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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