Gpr17 G protein-coupled receptor 17 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr17provided by MGI
Official Full Name: G protein-coupled receptor 17provided by MGI
Primary source: MGI:MGI:3584514
See related: Ensembl:ENSMUSG00000052229 AllianceGenome:MGI:3584514
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable G protein-coupled receptor activity and receptor serine/threonine kinase binding activity. Acts upstream of or within negative regulation of inflammatory response to antigenic stimulus. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in central nervous system; gut; and male reproductive gland or organ. Orthologous to human GPR17 (G protein-coupled receptor 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cortex adult (RPKM 9.4), frontal lobe adult (RPKM 8.2) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B1; 18 17.89 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (32076052..32082925, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (31942999..31949890, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown and inhibition of hippocampal GPR17 attenuates lipopolysaccharide-induced cognitive impairment in mice.
Title: Knockdown and inhibition of hippocampal GPR17 attenuates lipopolysaccharide-induced cognitive impairment in mice.
G protein-coupled receptor 17 is regulated by WNT pathway during oligodendrocyte precursor cell differentiation.
Title: G protein-coupled receptor 17 is regulated by WNT pathway during oligodendrocyte precursor cell differentiation.
Analysis of the GPR17 receptor in NG2-glia under physiological conditions unravels a new subset of oligodendrocyte progenitor cells with distinct functions.
Title: Analysis of the GPR17 receptor in NG2-glia under physiological conditions unravels a new subset of oligodendrocyte progenitor cells with distinct functions.
G protein-coupled receptor 17 restricts rabies virus replication via BAK-mediated apoptosis.
Title: G protein-coupled receptor 17 restricts rabies virus replication via BAK-mediated apoptosis.
Functional genomic analyses highlight a shift in Gpr17-regulated cellular processes in oligodendrocyte progenitor cells and underlying myelin dysregulation in the aged mouse cerebrum.
Title: Functional genomic analyses highlight a shift in Gpr17-regulated cellular processes in oligodendrocyte progenitor cells and underlying myelin dysregulation in the aged mouse cerebrum.
Intestinal Gpr17 deficiency improves glucose metabolism by promoting GLP-1 secretion.
Title: Intestinal Gpr17 deficiency improves glucose metabolism by promoting GLP-1 secretion.
Leanness and Low Plasma Leptin in GPR17 Knockout Mice Are Dependent on Strain and Associated With Increased Energy Intake That Is Not Suppressed by Exogenous Leptin.
Title: Leanness and Low Plasma Leptin in GPR17 Knockout Mice Are Dependent on Strain and Associated With Increased Energy Intake That Is Not Suppressed by Exogenous Leptin.
Microglial vesicles improve post-stroke recovery by preventing immune cell senescence and favoring oligodendrogenesis.
Title: Microglial vesicles improve post-stroke recovery by preventing immune cell senescence and favoring oligodendrogenesis.
Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia.
Title: Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia.
FLIM-FRET-Based Structural Characterization of a Class-A GPCR Dimer in the Cell Membrane.
Title: FLIM-FRET-Based Structural Characterization of a Class-A GPCR Dimer in the Cell Membrane.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH78384 (e-PCR)
- UniSTS:47022

AI853548 (e-PCR)
- UniSTS:166089

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor serine/threonine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of inflammatory response to antigenic stimulus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uracil nucleotide/cysteinyl leukotriene receptor

Names: UDP/CysLT receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.