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    PSCA prostate stem cell antigen [ Homo sapiens (human) ]

    Gene ID: 8000, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PSCAprovided by HGNC
    Official Full Name
    prostate stem cell antigenprovided by HGNC
    Primary source
    HGNC:HGNC:9500
    See related
    Ensembl:ENSG00000167653 MIM:602470; AllianceGenome:HGNC:9500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRO232; lncPSCA
    Summary
    This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
    Expression
    Biased expression in stomach (RPKM 721.2), urinary bladder (RPKM 108.9) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    8q24.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (142670297..142682725)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (143813825..143826193)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143751715..143764143)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928087 Neighboring gene Jrk helix-turn-helix protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143743050-143743570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143743571-143744089 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143748299-143749154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19603 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143762658-143763304 Neighboring gene uncharacterized LOC124902032 Neighboring gene lncRNA associated with ovarian cancer 1 Neighboring gene lymphocyte antigen 6 family member K

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The PSCA rs2294008 (C/T) Polymorphism Increases the Risk of Gastric and Bladder Cancer: A Meta-Analysis. Wang XF, et al. Genet Test Mol Biomarkers, 2023 Feb. PMID 36853840
    2. LncPSCA in the 8q24.3 risk locus drives gastric cancer through destabilizing DDX5. Zheng Y, et al. EMBO Rep, 2021 Nov 4. PMID 34472665, Free PMC Article
    3. Silencing of the proteasome and oxidative stress impair endoplasmic reticulum targeting and signal cleavage of a prostate carcinoma antigen. Hoefer F, et al. Biochem Biophys Res Commun, 2021 May 21. PMID 33774280
    4. The Correlation between PSCA Expression and Neuroendocrine Differentiation in Prostate Cancer. Xiang Q, et al. Biomed Res Int, 2020. PMID 33029516, Free PMC Article
    5. Evolutionary History of the Risk of SNPs for Diffuse-Type Gastric Cancer in the Japanese Population. Iwasaki RL, et al. Genes (Basel), 2020 Jul 10. PMID 32664326, Free PMC Article

    See all (142) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The PSCA rs2294008 (C/T) Polymorphism Increases the Risk of Gastric and Bladder Cancer: A Meta-Analysis.
      Title: The PSCA rs2294008 (C/T) Polymorphism Increases the Risk of Gastric and Bladder Cancer: A Meta-Analysis.
    2. Diagnostic Efficacy of PSMA and PSCA mRNAs Combined to PSA in Prostate Cancer Patients.
      Title: Diagnostic Efficacy of PSMA and PSCA mRNAs Combined to PSA in Prostate Cancer Patients.
    3. LncPSCA in the 8q24.3 risk locus drives gastric cancer through destabilizing DDX5.
      Title: LncPSCA in the 8q24.3 risk locus drives gastric cancer through destabilizing DDX5.
    4. Silencing of the proteasome and oxidative stress impair endoplasmic reticulum targeting and signal cleavage of a prostate carcinoma antigen.
      Title: Silencing of the proteasome and oxidative stress impair endoplasmic reticulum targeting and signal cleavage of a prostate carcinoma antigen.
    5. Polymorphisms PSCA rs2294008, IL-4 rs2243250 and MUC1 rs4072037 are associated with gastric cancer in a high risk population.
      Title: Polymorphisms PSCA rs2294008, IL-4 rs2243250 and MUC1 rs4072037 are associated with gastric cancer in a high risk population.
    6. Impact of PSCA Polymorphisms on the Risk of Duodenal Ulcer.
      Title: Impact of PSCA Polymorphisms on the Risk of Duodenal Ulcer.
    7. The Correlation between PSCA Expression and Neuroendocrine Differentiation in Prostate Cancer.
      Title: The Correlation between PSCA Expression and Neuroendocrine Differentiation in Prostate Cancer.
    8. Evolutionary History of the Risk of SNPs for Diffuse-Type Gastric Cancer in the Japanese Population.
      Title: Evolutionary History of the Risk of SNPs for Diffuse-Type Gastric Cancer in the Japanese Population.
    9. Risk of gastric ulcer contributed by genetic polymorphisms of PSCA: A case-control study based on Chinese Han population.
      Title: Risk of gastric ulcer contributed by genetic polymorphisms of PSCA: A case-control study based on Chinese Han population.
    10. Association of MUC1 5640G>A and PSCA 5057C>T polymorphisms with the risk of gastric cancer in Northern Iran.
      Title: Association of MUC1 5640G>A and PSCA 5057C>T polymorphisms with the risk of gastric cancer in Northern Iran.
    Submit: New GeneRIF Correction See all GeneRIFs (112)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population.
    EBI GWAS Catalog
    A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
    EBI GWAS Catalog
    Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer.
    EBI GWAS Catalog
    Genome-wide association study identifies multiple loci associated with bladder cancer risk.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables acetylcholine receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of neurotransmitter receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    prostate stem cell antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011722.3 RefSeqGene

      Range
      15188..17418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005672.5 → NP_005663.2  prostate stem cell antigen preproprotein

      See identical proteins and their annotated locations for NP_005663.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the functional protein.
      Source sequence(s)
      AI685668, BC048808, CB993163
      Consensus CDS
      CCDS47925.2
      UniProtKB/Swiss-Prot
      O43653, Q6UW92
      Related
      ENSP00000301258.4, ENST00000301258.5
      Conserved Domains (1) summary
      pfam00021
      Location:14 → 84
      UPAR_LY6; u-PAR/Ly-6 domain

    RNA

    1. NR_033343.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in its 5'-most exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame coding region, compared to variant 1.
      Source sequence(s)
      AC108002, AI685668, BC048808, BI758811, BU157227

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      142670297..142682725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      143813825..143826193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43653.2 GenPept UniProtKB/Swiss-Prot:O43653

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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