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    ZNF770 zinc finger protein 770 [ Homo sapiens (human) ]

    Gene ID: 54989, updated on 5-May-2024

    Summary

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    Official Symbol
    ZNF770provided by HGNC
    Official Full Name
    zinc finger protein 770provided by HGNC
    Primary source
    HGNC:HGNC:26061
    See related
    Ensembl:ENSG00000198146 AllianceGenome:HGNC:26061
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRO1914
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 32.4), skin (RPKM 18.5) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    15q14
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (34978341..34988287, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (32783551..32793491, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (35270542..35280488, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene tubulin alpha pseudogene 11 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:35166353-35167552 Neighboring gene aquarius intron-binding spliceosomal factor Neighboring gene Sharpr-MPRA regulatory region 15538 Neighboring gene ribosomal protein L36a pseudogene 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:35260004-35260568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9184 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:35277351-35278003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9185 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9186 Neighboring gene uncharacterized LOC105370764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9187 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:35285419-35286618 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:35287050-35287721 Neighboring gene uncharacterized LOC105370763 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:35312331-35313023 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:35345268-35345500 Neighboring gene uncharacterized LOC105370765 Neighboring gene Nanog homeobox retrogene P8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A genome-wide association study (GWAS) for bronchopulmonary dysplasia. Wang H, et al. Pediatrics, 2013 Aug. PMID 23897914, Free PMC Article
    2. Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations. Connaughton DM, et al. Am J Hum Genet, 2020 Oct 1. PMID 32891193, Free PMC Article
    3. UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair. Huang Q, et al. FASEB J, 2022 Jan. PMID 34921745
    4. The in vivo Interaction Landscape of Histones H3.1 and H3.3. Siddaway R, et al. Mol Cell Proteomics, 2022 Oct. PMID 36089195, Free PMC Article
    5. SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk. Lukinović V, et al. Cancer Discov, 2022 Sep 2. PMID 35819319, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20582

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 770

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014106.4 → NP_054825.2  zinc finger protein 770

      See identical proteins and their annotated locations for NP_054825.2

      Status: VALIDATED

      Source sequence(s)
      AC114546, AI031776, AK127201, AK131433, BC071603, DA331762
      Consensus CDS
      CCDS10042.1
      UniProtKB/Swiss-Prot
      Q6IQ21, Q6ZMZ6, Q9NWV2
      UniProtKB/TrEMBL
      A8K5X3
      Related
      ENSP00000348673.4, ENST00000356321.4
      Conserved Domains (3) summary
      COG5048
      Location:185 → 530
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:162 → 182
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:42 → 66
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      34978341..34988287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521744.4 → XP_011520046.1  zinc finger protein 770 isoform X1

      See identical proteins and their annotated locations for XP_011520046.1

      UniProtKB/Swiss-Prot
      Q6IQ21, Q6ZMZ6, Q9NWV2
      UniProtKB/TrEMBL
      A8K5X3
      Conserved Domains (3) summary
      COG5048
      Location:185 → 530
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:162 → 182
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:42 → 66
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      32783551..32793491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378346.1 → XP_054234321.1  zinc finger protein 770 isoform X1

      UniProtKB/Swiss-Prot
      Q6IQ21, Q6ZMZ6, Q9NWV2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IQ21.1 GenPept UniProtKB/Swiss-Prot:Q6IQ21

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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