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    FAM168A family with sequence similarity 168 member A [ Homo sapiens (human) ]

    Gene ID: 23201, updated on 7-Apr-2024

    Summary

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    Official Symbol
    FAM168Aprovided by HGNC
    Official Full Name
    family with sequence similarity 168 member Aprovided by HGNC
    Primary source
    HGNC:HGNC:28999
    See related
    Ensembl:ENSG00000054965 MIM:616316; AllianceGenome:HGNC:28999
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TCRP1; KIAA0280
    Summary
    Involved in positive regulation of base-excision repair. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 45.1), gall bladder (RPKM 10.1) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    11q13.4
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (73400487..73598112, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (73329624..73527246, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (73111532..73309157, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 17 Neighboring gene uncharacterized LOC124902710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73044313-73045026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73061599-73062100 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:73073093-73073599 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3741 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3742 Neighboring gene Sharpr-MPRA regulatory region 2034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3743 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73097219-73098168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73098169-73099116 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:73099117-73100064 Neighboring gene RELT TNF receptor Neighboring gene MPRA-validated peak1349 silencer Neighboring gene MPRA-validated peak1350 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73166211-73166710 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:73205355-73205873 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:73205874-73206391 Neighboring gene NANOG hESC enhancer GRCh37_chr11:73262685-73263225 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:73264745-73264969 Neighboring gene Sharpr-MPRA regulatory region 14801 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:73308491-73309219 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3745 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 38 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73336706-73337222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73337223-73337737 Neighboring gene MIA SH3 domain ER export factor 2 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:73357191-73358109 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5239 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr11:73371326-73372170 and GRCh37_chr11:73372171-73373013 Neighboring gene pleckstrin homology domain containing B1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. FAM168A participates in the development of chronic myeloid leukemia via BCR-ABL1/AKT1/NFκB pathway. Liu X, et al. BMC Cancer, 2019 Jul 10. PMID 31291942, Free PMC Article
    2. Purification and biochemical characterization of a novel protein-tongue cancer chemotherapy resistance-associated protein1 (TCRP1). Peng B, et al. Protein Expr Purif, 2012 Apr. PMID 22365988
    3. TCRP1 promotes radioresistance of oral squamous cell carcinoma cells via Akt signal pathway. Gu Y, et al. Mol Cell Biochem, 2011 Nov. PMID 21603883
    4. Cloning and functional characterization of TCRP1, a novel gene mediating resistance to cisplatin in an oral squamous cell carcinoma cell line. Gu Y, et al. FEBS Lett, 2011 Mar 23. PMID 21334329
    5. TCRP1 induces tamoxifen resistance by promoting the activation of SGK1 in MCF‑7 cells. Zhao S, et al. Oncol Rep, 2020 Jun. PMID 32323833, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TCRP1 induces tamoxifen resistance by promoting the activation of SGK1 in MCF7 cells.
      Title: TCRP1 induces tamoxifen resistance by promoting the activation of SGK1 in MCF‑7 cells.
    2. FAM168A involved in the regulation of AKT1/NFkappaB signaling pathway and cell cycle in chronic myeloid leukemia.
      Title: FAM168A participates in the development of chronic myeloid leukemia via BCR-ABL1/AKT1/NFκB pathway.
    3. Combined, these findings suggest that c-Myc could transcriptionally regulate TCRP1 in cell lines and clinical samples and identified the c-Myc-TCRP1 axis as a negative biomarker of prognosis in tongue and lung cancers.
      Title: TCRP1 transcriptionally regulated by c-Myc confers cancer chemoresistance in tongue and lung cancer.
    4. Our results highlight that hyper-methylation of miR-493CpG island might play important roles in the development of lung cancer chemo-resistance by targeting TCRP1, which might be used as a potential therapeutic target in preventing the chemo-resistance of lung cancer.
      Title: Epigenetic silencing of miR-493 increases the resistance to cisplatin in lung cancer by targeting tongue cancer resistance-related protein 1(TCRP1).
    5. Data show that tongue cancer resistance-associated protein 1 (TCRP1) contributes to cisplatin (DDP) resistance via the increased expression of DNA polymerase beta subunit (Pol beta) in lung cancer cells.
      Title: TCRP1 contributes to cisplatin resistance by preventing Pol β degradation in lung cancer cells.
    6. siRNA-mediated knockdown of TCRP1 and MT1X was found to sensitize cells to cisplatin, leading to increased apoptosis and inhibition of cell proliferation
      Title: Microarray-assisted pathway analysis identifies MT1X & NFκB as mediators of TCRP1-associated resistance to cisplatin in oral squamous cell carcinoma.
    7. Data suggest that TCRP1 (EF363480) might be a novel molecular target to develop agents to reverse cisplatin-induced chemoresistance.
      Title: Cloning and functional characterization of TCRP1, a novel gene mediating resistance to cisplatin in an oral squamous cell carcinoma cell line.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0280

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of base-excision repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein FAM168A
    Names
    tongue cancer chemotherapy resistance-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286050.2 → NP_001272979.1  protein FAM168A isoform 1

      See identical proteins and their annotated locations for NP_001272979.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AP000763, BC052341, D87470, DB074440
      Consensus CDS
      CCDS73346.1
      UniProtKB/Swiss-Prot
      A2ICY2, A2ID81, Q86UG2, Q92567
      Related
      ENSP00000064778.4, ENST00000064778.8
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 244
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    2. NM_001286051.2 → NP_001272980.1  protein FAM168A isoform 3

      See identical proteins and their annotated locations for NP_001272980.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks three alternate in-frame exons, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AP000763, DB074440, EF197985
      Consensus CDS
      CCDS66165.1
      UniProtKB/Swiss-Prot
      Q92567
      Related
      ENSP00000390501.2, ENST00000450446.6
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 129
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    3. NM_015159.3 → NP_055974.1  protein FAM168A isoform 2

      See identical proteins and their annotated locations for NP_055974.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AP000763, BC052341
      Consensus CDS
      CCDS41689.1
      UniProtKB/Swiss-Prot
      Q92567
      Related
      ENSP00000348852.4, ENST00000356467.5
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 235
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      73400487..73598112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426650.1 → XP_047282606.1  protein FAM168A isoform X1

    2. XM_017017415.3 → XP_016872904.1  protein FAM168A isoform X2

      Conserved Domains (1) summary
      pfam14944
      Location:1 → 193
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      73329624..73527246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368190.1 → XP_054224165.1  protein FAM168A isoform X1

    2. XM_054368191.1 → XP_054224166.1  protein FAM168A isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92567.2 GenPept UniProtKB/Swiss-Prot:Q92567

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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