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    Acap2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [ Mus musculus (house mouse) ]

    Gene ID: 78618, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Acap2provided by MGI
    Official Full Name
    ArfGAP with coiled-coil, ankyrin repeat and PH domains 2provided by MGI
    Primary source
    MGI:MGI:1925868
    See related
    Ensembl:ENSMUSG00000049076 AllianceGenome:MGI:1925868
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CNT-B2; Centb2; mKIAA0041; 4832442G16; 9530039J15Rik
    Summary
    Enables phosphatidylinositol-3,5-bisphosphate binding activity and small GTPase binding activity. Predicted to be involved in cellular response to nerve growth factor stimulus and endocytic recycling. Predicted to act upstream of or within actin filament-based process. Predicted to be located in ruffle. Predicted to be active in endosome membrane. Is expressed in several structures, including adipose tissue; brain; genitourinary system; liver; and spleen. Orthologous to human ACAP2 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 7.0), frontal lobe adult (RPKM 5.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 B2; 16 21.34 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (30911230..31020105, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (31092412..31201285, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene xyloside xylosyltransferase 1 Neighboring gene predicted gene, 41440 Neighboring gene STARR-positive B cell enhancer ABC_E7437 Neighboring gene STARR-positive B cell enhancer ABC_E11610 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:31081520-31081703 Neighboring gene predicted gene, 46554 Neighboring gene zinc finger protein 161 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40608 Neighboring gene STARR-positive B cell enhancer ABC_E4163 Neighboring gene STARR-positive B cell enhancer ABC_E7438 Neighboring gene predicted gene, 52237 Neighboring gene STARR-seq mESC enhancer starr_40609 Neighboring gene predicted gene, 41442 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rab35 regulates phagosome formation through recruitment of ACAP2 in macrophages during FcγR-mediated phagocytosis. Egami Y, et al. J Cell Sci, 2011 Nov 1. PMID 22045739
    2. ACAP3 regulates neurite outgrowth through its GAP activity specific to Arf6 in mouse hippocampal neurons. Miura Y, et al. Biochem J, 2016 Sep 1. PMID 27330119
    3. Rab35 establishes the EHD1-association site by coordinating two distinct effectors during neurite outgrowth. Kobayashi H, et al. J Cell Sci, 2013 Jun 1. PMID 23572513
    4. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Dowler S, et al. Biochem J, 2000 Oct 1. PMID 11001876, Free PMC Article
    5. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Theisen DJ, et al. Science, 2018 Nov 9. PMID 30409884, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rab35 regulates phagosome formation through recruitment of ACAP2 in macrophages during FcgammaR-mediated phagocytosis.
      Title: Rab35 regulates phagosome formation through recruitment of ACAP2 in macrophages during FcγR-mediated phagocytosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament-based process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to nerve growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
    Names
    centaurin, beta 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030138.2 → NP_084414.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

      See identical proteins and their annotated locations for NP_084414.1

      Status: VALIDATED

      Source sequence(s)
      AC090430, AK129041, BB465902, BY014253
      Consensus CDS
      CCDS49823.1
      UniProtKB/Swiss-Prot
      Q3UHL4, Q6ZQK5, Q811F3, Q9CTS8
      Related
      ENSMUSP00000154983.2, ENSMUST00000230614.2
      Conserved Domains (7) summary
      cd07638
      Location:18 → 217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      smart00105
      Location:402 → 518
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:602 → 718
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:269 → 365
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:267 → 361
      PH; PH domain
      pfam12796
      Location:602 → 696
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:630 → 663
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      30911230..31020105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522747.5 → XP_006522810.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A338P6P6
      Related
      ENSMUSP00000156077.2, ENSMUST00000229010.3
      Conserved Domains (7) summary
      PTZ00322
      Location:669 → 753
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:18 → 217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      COG5347
      Location:387 → 624
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd13250
      Location:269 → 365
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:665 → 698
      ANK; ANK repeat [structural motif]
      cd08851
      Location:399 → 513
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      pfam13637
      Location:637 → 688
      Ank_4; Ankyrin repeats (many copies)

    2. XM_006522746.5 → XP_006522809.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X3

      Conserved Domains (7) summary
      PTZ00322
      Location:673 → 757
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:18 → 217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      COG5347
      Location:391 → 628
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd13250
      Location:273 → 369
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:669 → 702
      ANK; ANK repeat [structural motif]
      cd08851
      Location:403 → 517
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      pfam13637
      Location:641 → 692
      Ank_4; Ankyrin repeats (many copies)

    3. XM_006522743.5 → XP_006522806.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1

      Conserved Domains (7) summary
      PTZ00322
      Location:680 → 764
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:18 → 217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      COG5347
      Location:398 → 635
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd13250
      Location:273 → 376
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:676 → 709
      ANK; ANK repeat [structural motif]
      cd08851
      Location:410 → 524
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      pfam13637
      Location:648 → 699
      Ank_4; Ankyrin repeats (many copies)

    4. XM_006522749.5 → XP_006522812.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X6

      See identical proteins and their annotated locations for XP_006522812.1

      UniProtKB/TrEMBL
      D4AFX6
      Related
      ENSMUSP00000154852.2, ENSMUST00000231125.2
      Conserved Domains (6) summary
      PTZ00322
      Location:641 → 725
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:18 → 217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      cd13250
      Location:269 → 372
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:637 → 670
      ANK; ANK repeat [structural motif]
      cd08851
      Location:406 → 520
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      pfam13637
      Location:609 → 660
      Ank_4; Ankyrin repeats (many copies)

    5. XM_006522744.5 → XP_006522807.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X2

      Conserved Domains (7) summary
      PTZ00322
      Location:676 → 760
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:18 → 217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      COG5347
      Location:394 → 631
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd13250
      Location:269 → 372
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:672 → 705
      ANK; ANK repeat [structural motif]
      cd08851
      Location:406 → 520
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      pfam13637
      Location:644 → 695
      Ank_4; Ankyrin repeats (many copies)

    6. XM_006522748.5 → XP_006522811.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X5

      Conserved Domains (6) summary
      PTZ00322
      Location:645 → 729
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:18 → 217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      cd13250
      Location:273 → 376
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:641 → 674
      ANK; ANK repeat [structural motif]
      cd08851
      Location:410 → 524
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      pfam13637
      Location:613 → 664
      Ank_4; Ankyrin repeats (many copies)

    7. XM_017317162.2 → XP_017172651.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X7

      Conserved Domains (6) summary
      PTZ00322
      Location:638 → 722
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:18 → 217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      cd13250
      Location:273 → 369
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:634 → 667
      ANK; ANK repeat [structural motif]
      cd08851
      Location:403 → 517
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      pfam13637
      Location:606 → 657
      Ank_4; Ankyrin repeats (many copies)

    8. XM_017317163.3 → XP_017172652.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X8

      Conserved Domains (7) summary
      PTZ00322
      Location:489 → 573
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      COG5347
      Location:207 → 444
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd13250
      Location:82 → 185
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:485 → 518
      ANK; ANK repeat [structural motif]
      cd08851
      Location:219 → 333
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      pfam13637
      Location:457 → 508
      Ank_4; Ankyrin repeats (many copies)
      cl12013
      Location:1 → 47
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    9. XM_036160182.1 → XP_036016075.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X8

      Conserved Domains (7) summary
      PTZ00322
      Location:489 → 573
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      COG5347
      Location:207 → 444
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd13250
      Location:82 → 185
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:485 → 518
      ANK; ANK repeat [structural motif]
      cd08851
      Location:219 → 333
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      pfam13637
      Location:457 → 508
      Ank_4; Ankyrin repeats (many copies)
      cl12013
      Location:1 → 47
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    10. XM_017317164.3 → XP_017172653.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X9

      Conserved Domains (6) summary
      PTZ00322
      Location:443 → 527
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd13250
      Location:78 → 174
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:439 → 472
      ANK; ANK repeat [structural motif]
      cd08851
      Location:208 → 322
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      pfam13637
      Location:411 → 462
      Ank_4; Ankyrin repeats (many copies)
      cl12013
      Location:1 → 47
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_384614.5 RNA Sequence

    2. XR_384613.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZQK5.2 GenPept UniProtKB/Swiss-Prot:Q6ZQK5

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