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    UTP23 UTP23 small subunit processome component [ Homo sapiens (human) ]

    Gene ID: 84294, updated on 23-Mar-2024

    Summary

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    Official Symbol
    UTP23provided by HGNC
    Official Full Name
    UTP23 small subunit processome componentprovided by HGNC
    Primary source
    HGNC:HGNC:28224
    See related
    Ensembl:ENSG00000147679 AllianceGenome:HGNC:28224
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C8orf53
    Summary
    Enables mRNA 3'-UTR binding activity and mRNA 5'-UTR binding activity. Predicted to be involved in rRNA processing. Predicted to act upstream of or within endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Implicated in colorectal adenocarcinoma. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 6.0), ovary (RPKM 5.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    8q24.11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (116766524..116774684)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (117894649..117917286)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (117778763..117786923)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27827 Neighboring gene uncharacterized LOC105375713 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27828 Neighboring gene eukaryotic translation initiation factor 3 subunit H Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:117690347-117691260 Neighboring gene NANOG hESC enhancer GRCh37_chr8:117702562-117703067 Neighboring gene NANOG hESC enhancer GRCh37_chr8:117742295-117742846 Neighboring gene uncharacterized LOC124902006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27830 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27831 Neighboring gene uncharacterized LOC112268030 Neighboring gene RAD21 cohesin complex component Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19473 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27832 Neighboring gene RAD21 antisense RNA 1 Neighboring gene microRNA 3610

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Down-regulation of UTP23 promotes paclitaxel resistance and predicts poorer prognosis in ovarian cancer. Fu Z, et al. Pathol Res Pract, 2019 Nov. PMID 31540773
    2. The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation. Bleichert F, et al. Proc Natl Acad Sci U S A, 2006 Jun 20. PMID 16769905, Free PMC Article
    3. Utp23p is required for dissociation of snR30 small nucleolar RNP from preribosomal particles. Hoareau-Aveilla C, et al. Nucleic Acids Res, 2012 Apr. PMID 22180534, Free PMC Article
    4. The ribosome biogenesis factor yUtp23/hUTP23 coordinates key interactions in the yeast and human pre-40S particle and hUTP23 contains an essential PIN domain. Wells GR, et al. Nucleic Acids Res, 2017 May 5. PMID 28082392, Free PMC Article
    5. Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Takagi M, et al. Cell, 2005 Oct 7. PMID 16213212

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cytoplasmic expression of UTP23 promotes colorectal cancer progression.
      Title: Cytoplasmic expression of UTP23 promotes colorectal cancer progression.
    2. UTP23 Is a Promising Prognostic Biomarker and Is Associated with Immune Infiltration in Breast Cancer.
      Title: UTP23 Is a Promising Prognostic Biomarker and Is Associated with Immune Infiltration in Breast Cancer.
    3. UTP23 Functions in Breast Cancer Progression and Predicts Poor Prognosis of Luminal a Breast Cancer.
      Title: UTP23 Functions in Breast Cancer Progression and Predicts Poor Prognosis of Luminal a Breast Cancer.
    4. Our findings elucidated a previously unknown function for UTP23 in regulating paclitaxel sensitivity and UTP23 could serve as a potential prognostic predictor for ovarian cancer
      Title: Down-regulation of UTP23 promotes paclitaxel resistance and predicts poorer prognosis in ovarian cancer.
    5. yUtp23/hUTP23 could therefore be central to the coordinated integration and release of ES6 binding factors and likely plays a pivotal role in remodeling this pre-rRNA region in both yeast and humans. Finally, studies using RNAi-rescue systems in human cells revealed that intact PIN domain and Zinc finger motifs in human hUTP23 are essential for 18S rRNA maturation.
      Title: The ribosome biogenesis factor yUtp23/hUTP23 coordinates key interactions in the yeast and human pre-40S particle and hUTP23 contains an essential PIN domain.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC14595

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 5'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small ribosomal subunit rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rRNA-processing protein UTP23 homolog
    Names
    UTP23, small subunit (SSU) processome component, homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032334.3 → NP_115710.2  rRNA-processing protein UTP23 homolog

      See identical proteins and their annotated locations for NP_115710.2

      Status: VALIDATED

      Source sequence(s)
      AC087350, AK315770, AP002905, BP231814
      Consensus CDS
      CCDS6320.1
      UniProtKB/Swiss-Prot
      B2RE25, Q96NJ8, Q9BRU9
      Related
      ENSP00000308332.2, ENST00000309822.7
      Conserved Domains (1) summary
      cd09866
      Location:2 → 148
      PIN_Fcf1-Utp23-H; PIN domain of rRNA-processing protein Fcf1- and Utp23-like homologs found in eukaryotes except fungi

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      116766524..116774684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      117894649..117917286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361351.1 → XP_054217326.1  rRNA-processing protein UTP23 homolog isoform X1

      UniProtKB/Swiss-Prot
      B2RE25, Q96NJ8, Q9BRU9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BRU9.2 GenPept UniProtKB/Swiss-Prot:Q9BRU9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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