SLC16A1 solute carrier family 16 member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC16A1provided by HGNC
Official Full Name: solute carrier family 16 member 1provided by HGNC
Primary source: HGNC:HGNC:10922
See related: Ensembl:ENSG00000155380 MIM:600682; AllianceGenome:HGNC:10922
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MCT; HHF7; MCT1; MCT1D
Summary: The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]
Expression: Broad expression in heart (RPKM 23.3), colon (RPKM 22.1) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p13.2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (112911847..112956196, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (112924405..112968780, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (113454469..113498818, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oncogenic circ-SLC16A1 promotes progression of non-small cell lung cancer via regulation of the miR-1287-5p/profilin 2 axis.
Title: Oncogenic circ-SLC16A1 promotes progression of non-small cell lung cancer via regulation of the miR-1287-5p/profilin 2 axis.
To initiate or not to initiate: A critical assessment of eIF2A, eIF2D, and MCT-1.DENR to deliver initiator tRNA to ribosomes.
Title: To initiate or not to initiate: A critical assessment of eIF2A, eIF2D, and MCT-1·DENR to deliver initiator tRNA to ribosomes.
MCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylation.
Title: MCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylation.
Role of monocarboxylate transporter I/lactate dehydrogenase B-mediated lactate recycling in tamoxifen-resistant breast cancer cells.
Title: Role of monocarboxylate transporter I/lactate dehydrogenase B-mediated lactate recycling in tamoxifen-resistant breast cancer cells.
SETDB1 Methylates MCT1 Promoting Tumor Progression by Enhancing the Lactate Shuttle.
Title: SETDB1 Methylates MCT1 Promoting Tumor Progression by Enhancing the Lactate Shuttle.
Comprehensive analysis of pan-cancer reveals the potential of SLC16A1 as a prognostic and immunological biomarker.
Title: Comprehensive analysis of pan-cancer reveals the potential of SLC16A1 as a prognostic and immunological biomarker.
Prognostic Value of Monocarboxylate Transporter 1 Overexpression in Cancer: A Systematic Review.
Title: Prognostic Value of Monocarboxylate Transporter 1 Overexpression in Cancer: A Systematic Review.
Immunohistochemical evaluation and prognostic value of monocarboxylate transporter 1 (MCT1) and 4 (MCT4) in T-cell non-Hodgkin lymphoma.
Title: Immunohistochemical evaluation and prognostic value of monocarboxylate transporter 1 (MCT1) and 4 (MCT4) in T-cell non-Hodgkin lymphoma.
Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis.
Title: Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis.
Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l-lactate transport in the hepatocellular carcinoma cell line.
Title: Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l-lactate transport in the hepatocellular carcinoma cell line.

Submit: New GeneRIF Correction See all GeneRIFs (166)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Exercise-induced hyperinsulinism MedGen: C1864902 OMIM: 610021 GeneReviews: Familial Hyperinsulinism	Compare labs
Ketoacidosis due to monocarboxylate transporter-1 deficiency MedGen: C4015186 OMIM: 616095 GeneReviews: Not available	Compare labs
Metabolic myopathy due to lactate transporter defect MedGen: C1855577 OMIM: 245340 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Bda32a02 (e-PCR)
- UniSTS:74511

GDB:633352 (e-PCR)
- UniSTS:158509

D8S2279 (e-PCR)
- UniSTS:473907

D1S2287 (e-PCR)
- UniSTS:153651

Slc16a1 (e-PCR), detects polymorphism
- UniSTS:461930

SHGC-12946 (e-PCR)
- UniSTS:21866

D1S1423 (e-PCR)
- UniSTS:149619

D1S1425 (e-PCR)
- UniSTS:149621

D1S1431 (e-PCR)
- UniSTS:149627

A009K27 (e-PCR)
- UniSTS:11132

RH36905 (e-PCR)
- UniSTS:87932

RH69982 (e-PCR)
- UniSTS:42383

SHGC-132119 (e-PCR)
- UniSTS:170658

D1S3034 (e-PCR)
- UniSTS:21667

G32617 (e-PCR)
- UniSTS:117200

SLC16A1_833 (e-PCR)
- UniSTS:277720

94 (e-PCR), detects polymorphism
- UniSTS:50648

D1S1896E (e-PCR)
- UniSTS:59880

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables carboxylic acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables lactate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables lactate transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables lactate:proton symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lactate:proton symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables mevalonate transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables monocarboxylic acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables monocarboxylic acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables organic cyclic compound binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables succinate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in behavioral response to nutrient	IEA Inferred from Electronic Annotation more info
involved_in carboxylic acid transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
involved_in centrosome cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in mevalonate transport	TAS Traceable Author Statement more info	PubMed
involved_in monocarboxylic acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monocarboxylic acid transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in plasma membrane lactate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma membrane lactate transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in plasma membrane lactate transport	TAS Traceable Author Statement more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in pyruvate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in pyruvate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in response to food	IEA Inferred from Electronic Annotation more info
involved_in succinate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transport across blood-brain barrier	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cell junction	IDA Inferred from Direct Assay more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: monocarboxylate transporter 1

Names: MCT 1; solute carrier family 16 (monocarboxylate transporter), member 1; solute carrier family 16 (monocarboxylic acid transporters), member 1; solute carrier family 16, member 1 (monocarboxylic acid transporter 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_015880.2 RefSeqGene

Range

4733..49082

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001166496.2 → NP_001159968.1 monocarboxylate transporter 1

See identical proteins and their annotated locations for NP_001159968.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AI656300, AK094064, AK296688, AL158844, AL162079, BC026317, BP294493

Consensus CDS

CCDS858.1

UniProtKB/Swiss-Prot

P53985, Q49A45, Q5T8R6, Q9NSJ9

UniProtKB/TrEMBL

B2R6A5

Related

ENSP00000441065.1, ENST00000538576.5

Conserved Domains (1) summary

TIGR00892
Location:1 → 455

2A0113; monocarboxylate transporter 1
NM_003051.4 → NP_003042.3 monocarboxylate transporter 1

See identical proteins and their annotated locations for NP_003042.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AL158844

Consensus CDS

CCDS858.1

UniProtKB/Swiss-Prot

P53985, Q49A45, Q5T8R6, Q9NSJ9

UniProtKB/TrEMBL

B2R6A5

Related

ENSP00000358640.4, ENST00000369626.8

Conserved Domains (1) summary

TIGR00892
Location:1 → 455

2A0113; monocarboxylate transporter 1