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    Slco1a4 solute carrier organic anion transporter family, member 1a4 [ Mus musculus (house mouse) ]

    Gene ID: 28250, updated on 7-May-2024

    Summary

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    Official Symbol
    Slco1a4provided by MGI
    Official Full Name
    solute carrier organic anion transporter family, member 1a4provided by MGI
    Primary source
    MGI:MGI:1351896
    See related
    Ensembl:ENSMUSG00000030237 AllianceGenome:MGI:1351896
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Oatp2; Oatp1a4; Slc21a5
    Summary
    Enables organic anion transmembrane transporter activity. Acts upstream of or within anion transport. Located in membrane. Is expressed in choroid invagination; choroid plexus; diencephalon roof plate; medulla oblongata part of 4th ventricle choroid plexus; and metencephalon part of 4th ventricle choroid plexus. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in frontal lobe adult (RPKM 9.8), cortex adult (RPKM 8.3) and 2 other tissues See more
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    Genomic context

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    Location:
    6 G2; 6 72.9 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (141751164..141802011, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (141805438..141856284, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family, member 1b2 Neighboring gene STARR-seq mESC enhancer starr_17695 Neighboring gene solute carrier organic anion transporter family, member 1a7 Neighboring gene STARR-seq mESC enhancer starr_17696 Neighboring gene STARR-seq mESC enhancer starr_17697 Neighboring gene STARR-seq mESC enhancer starr_17698 Neighboring gene predicted gene, 30784 Neighboring gene predicted gene, 30843 Neighboring gene solute carrier organic anion transporter family, member 1a1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Organic Anion Transporting Polypeptide 1a4 is Responsible for the Hepatic Uptake of Cardiac Glycosides in Mice. Takano J, et al. Drug Metab Dispos, 2018 May. PMID 29348124
    2. Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism. Zhang Y, et al. Biochem Pharmacol, 2013 Aug 1. PMID 23747753, Free PMC Article
    3. Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier. Ose A, et al. Drug Metab Dispos, 2010 Jan. PMID 19833843
    4. Genomic organization and tissue-specific expression of splice variants of mouse organic anion transporting polypeptide 2. Ogura K, et al. Biochem Biophys Res Commun, 2001 Feb 23. PMID 11181066
    5. Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice. Zhang Y, et al. PLoS One, 2012. PMID 22496825, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Oatp1a4 plays a major role in the hepatic accumulation of cardiac glycosides in mice.
      Title: Organic Anion Transporting Polypeptide 1a4 is Responsible for the Hepatic Uptake of Cardiac Glycosides in Mice.
    2. Oatp1a4 does not appear to mediate the hepatic uptake of bile acid, but plays an important male-predominant role in secondary bile acid metabolism.
      Title: Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism.
    3. Oatp1a4 is more highly expressed in females than in males. Null mice showed inhibited hepatocyte transporter functions and an altered urinary metabolome.
      Title: Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles.
    4. Results show that Oatp1a4 can mediate the brain-to-blood and blood-to-brain transport of its substrate drugs across the blood-brain barrier.
      Title: Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier.
    5. Report critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp1a4 uptake transporter in mouse liver.
      Title: Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables bile acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bile acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables organic anion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic anion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium-independent organic anion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier organic anion transporter family member 1A4
    Names
    organic anion transporting polypeptide 2
    sodium-independent organic anion-transporting polypeptide 2
    solute carrier family 21 (organic anion transporter), member 5
    solute carrier family 21 member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355577.2 → NP_001342506.1  solute carrier organic anion transporter family member 1A4

      Status: VALIDATED

      Source sequence(s)
      AC156277, AC164572
      Consensus CDS
      CCDS39690.1
      UniProtKB/Swiss-Prot
      Q9EP96
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 625
      oat; sodium-independent organic anion transporter

    2. NM_001410657.1 → NP_001397586.1  solute carrier organic anion transporter family member 1A4

      Status: VALIDATED

      Source sequence(s)
      AC156277, AC164572
      UniProtKB/Swiss-Prot
      Q9EP96

    3. NM_030687.3 → NP_109612.1  solute carrier organic anion transporter family member 1A4

      See identical proteins and their annotated locations for NP_109612.1

      Status: VALIDATED

      Source sequence(s)
      AC156277, AC164572
      Consensus CDS
      CCDS39690.1
      UniProtKB/Swiss-Prot
      Q9EP96
      Related
      ENSMUSP00000130746.2, ENSMUST00000165990.8
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 625
      oat; sodium-independent organic anion transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      141751164..141802011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166207.1 → XP_036022100.1  solute carrier organic anion transporter family member 1A4 isoform X3

      Conserved Domains (1) summary
      TIGR00805
      Location:16 → 411
      oat; sodium-independent organic anion transporter

    2. XM_036166204.1 → XP_036022097.1  solute carrier organic anion transporter family member 1A4 isoform X1

      UniProtKB/Swiss-Prot
      Q9EP96
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 625
      oat; sodium-independent organic anion transporter

    3. XM_036166203.1 → XP_036022096.1  solute carrier organic anion transporter family member 1A4 isoform X1

      UniProtKB/Swiss-Prot
      Q9EP96
      Related
      ENSMUSP00000032364.8, ENSMUST00000032364.14
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 625
      oat; sodium-independent organic anion transporter

    4. XM_036166206.1 → XP_036022099.1  solute carrier organic anion transporter family member 1A4 isoform X2

      Conserved Domains (1) summary
      TIGR00805
      Location:5 → 564
      oat; sodium-independent organic anion transporter

    5. XM_011241585.3 → XP_011239887.1  solute carrier organic anion transporter family member 1A4 isoform X1

      See identical proteins and their annotated locations for XP_011239887.1

      UniProtKB/Swiss-Prot
      Q9EP96
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 625
      oat; sodium-independent organic anion transporter

    6. XM_036166205.1 → XP_036022098.1  solute carrier organic anion transporter family member 1A4 isoform X2

      Conserved Domains (1) summary
      TIGR00805
      Location:5 → 564
      oat; sodium-independent organic anion transporter

    RNA

    1. XR_003956207.2 RNA Sequence

    2. XR_003956206.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EP96.1 GenPept UniProtKB/Swiss-Prot:Q9EP96

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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