Slc31a1 solute carrier family 31 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc31a1provided by RGD
Official Full Name: solute carrier family 31 member 1provided by RGD
Primary source: RGD:620059
See related: Ensembl:ENSRNOG00000014475 AllianceGenome:RGD:620059
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ctr1; LRRGT00200
Summary: Enables copper ion transmembrane transporter activity. Involved in cellular response to cisplatin and copper ion import across plasma membrane. Located in cytoplasm; neuronal cell body; and plasma membrane. Orthologous to human SLC31A1 (solute carrier family 31 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 610.6), Kidney (RPKM 501.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (80830574..80859810)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (75814744..75844241)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (78222504..78249358)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CTR1 and ATP7A play important roles in Cu transport in choroidal epithelial cells, and the Pb-induced intracellular Cu accumulation appears to be mediated, at least in part, via the alteration of CTR1 and ATP7A expression levels following Pb exposure.
Title: Involvement of CTR1 and ATP7A in lead (Pb)-induced copper (Cu) accumulation in choroidal epithelial cells.
Data suggest that Ctr1 is responsible for transport (and accumulation) of copper salts (CuCl2; CuSO4) and organoplatinum compounds in dorsal root ganglion neurons; Ctr1 is thus involved in neurotoxicity of such antineoplastic drugs.
Title: Contributions of rat Ctr1 to the uptake and toxicity of copper and platinum anticancer drugs in dorsal root ganglion neurons.
These data indicate that CTR1, but not DMT1, plays an essential role in transporting Cu by the blood-CSF barrier in the choroid plexus
Title: Relative contribution of CTR1 and DMT1 in copper transport by the blood-CSF barrier: implication in manganese-induced neurotoxicity.
these results suggest that Ctr1, DMT1, ATOX1 and ATP7A contribute to Cu transport at the blood-CSF barrier
Title: Mechanism of copper transport at the blood-cerebrospinal fluid barrier: influence of iron deficiency in an in vitro model.
Adult rat DRG tissue exhibits a specific pattern of expression of copper transporters with distinct subsets of peripheral sensory neurons intensely expressing either ATP7A or CTR1, but not both or ATP7B.
Title: Differential expression of ATP7A, ATP7B and CTR1 in adult rat dorsal root ganglion tissue.
Data show apical localization of Ctr1 in intestinal epithelia and suggest that increased Ctr1 apical localization in response to dietary copper limitation may represent an adaptive response to modulate Ctr1 availability at the site of copper absorption.
Title: Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability.
The presence of mRNA and of immunoreactivity of the copper transport protein Ctr1 in astrocyte cultures suggests that Ctr1 contributes to the observed copper accumulation.
Title: Copper accumulation by cultured astrocytes.
Prolactin stimulated Cu transport as a result of increased Ctr1 and Atp7A abundance at the plasma membrane in mammary gland
Title: Mammary gland copper transport is stimulated by prolactin through alterations in Ctr1 and Atp7A localization.
It has been shown that SLC31A1 gene activity correlates with the rate of both intracellular and extracellular copper-containing enzymes formation.
Title: [Relations between CTR1 gene activity and copper status in different rat organs].

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General gene information

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Markers

RH129201 (e-PCR)
- UniSTS:212509

RH128029 (e-PCR)
- UniSTS:211338

RH133724 (e-PCR)
- UniSTS:217007

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables copper ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables copper ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables copper ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables silver ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables silver ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables silver ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables xenobiotic transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to cisplatin	IDA Inferred from Direct Assay more info	PubMed
involved_in copper ion import	IDA Inferred from Direct Assay more info	PubMed
involved_in copper ion import	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within copper ion import	ISO Inferred from Sequence Orthology more info
involved_in copper ion import	ISO Inferred from Sequence Orthology more info
involved_in copper ion import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in copper ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in copper ion transport	ISO Inferred from Sequence Orthology more info
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in intracellular copper ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular copper ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane copper ion transport	IEA Inferred from Electronic Annotation more info
involved_in plasma membrane copper ion transport	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane copper ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein complex oligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein complex oligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein complex oligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in silver ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in silver ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in silver ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in vascular endothelial growth factor receptor-2 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor receptor-2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor receptor-2 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in xenobiotic transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in intercalated disc	IEA Inferred from Electronic Annotation more info
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: high affinity copper uptake protein 1

Names: Copper uptake transporter 1; copper transporter 1; liver regeneration-related protein LRRGT00200; rCTR1; solute carrier family 31 (copper transporter), member 1; solute carrier family 31 (copper transporters), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133600.3 → NP_598284.1 high affinity copper uptake protein 1

See identical proteins and their annotated locations for NP_598284.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q53YN6, Q9JK41

UniProtKB/TrEMBL

A0A8I6AQ78, A6J7U0

Conserved Domains (1) summary

pfam04145
Location:42 → 172

Ctr; Ctr copper transporter family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

80830574..80859810

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109222.2 → XP_038965150.1 high affinity copper uptake protein 1 isoform X1

UniProtKB/Swiss-Prot

Q53YN6, Q9JK41

UniProtKB/TrEMBL

A0A8I6AQ78, A6J7U0

Conserved Domains (1) summary

pfam04145
Location:42 → 172

Ctr; Ctr copper transporter family
XM_063287116.1 → XP_063143186.1 high affinity copper uptake protein 1 isoform X1

UniProtKB/Swiss-Prot

Q53YN6, Q9JK41

UniProtKB/TrEMBL

A6J7U0