RNF14 ring finger protein 14 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RNF14provided by HGNC
Official Full Name: ring finger protein 14provided by HGNC
Primary source: HGNC:HGNC:10058
See related: Ensembl:ENSG00000013561 MIM:605675; AllianceGenome:HGNC:10058
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ARA54; HFB30; TRIAD2; HRIHFB2038
Summary: The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]
Expression: Ubiquitous expression in testis (RPKM 10.0), thyroid (RPKM 8.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q31.3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (141949337..141990292)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (142475299..142516212)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (141346408..141369857)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks.
Title: RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks.
Ring Finger Protein 14 (RNF14) is a binding partner for all TCF/LEF transcription factors.
Title: Ring Finger Protein 14 is a new regulator of TCF/β-catenin-mediated transcription and colon cancer cell survival.
Differential localization of ARA54 may play an important role in testicular development and spermatogenesis in humans.
Title: Expression of androgen receptor co-regulators in the testes of men with azoospermia.
mRNA expression of ARA54 correlates with that of cyclin D1 in human colon carcinoma cells, indicating that ARA54 is not only involved in the regulation of cyclin D1 expression in cultured cell lines but also in clinical cancer specimens.
Title: ARA54 is involved in transcriptional regulation of the cyclin D1 gene in human cancer cells.
ARA54, might have dual in vivo roles functioning as both a direct coactivator and as an indirect mediator in AR function.
Title: Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth.
ARA54 role in prostate carcinoma progression may in may involve function as androgen receptor coactivator and focal adhesion protein
Title: Expression of androgen receptor coactivators in normal and cancer prostate tissues and cultured cell lines.
Dual functional roles for ARA54 as an AR coregulator directly and as a mediator for the suppressive effect of hnRNP A1 indirectly.
Title: Suppression of androgen receptor transactivation and prostate cancer cell growth by heterogeneous nuclear ribonucleoprotein A1 via interaction with androgen receptor coregulator ARA54.
dominant-negative AR coregulator can suppress AR transactivation and cell proliferation in prostate cancer cells
Title: A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

WI-17093 (e-PCR)
- UniSTS:68393

RH65859 (e-PCR)
- UniSTS:60718

D8S2279 (e-PCR)
- UniSTS:473907

D10S16 (e-PCR)
- UniSTS:155756

D1S1425 (e-PCR)
- UniSTS:149621

D11S3114 (e-PCR)
- UniSTS:152207

G42992 (e-PCR)
- UniSTS:94863

RH17835 (e-PCR)
- UniSTS:59558

SGC31927 (e-PCR)
- UniSTS:3801

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables nuclear androgen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	TAS Traceable Author Statement more info	PubMed
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-like protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in androgen receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in protein K6-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEP Inferred from Expression Pattern more info	PubMed
involved_in protein-RNA covalent cross-linking repair	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of androgen receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in rescue of stalled ribosome	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
is_active_in cytosolic ribosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF14

Names: androgen receptor associated protein 54

NP_001188294.1

EC 2.3.2.31

NP_004281.1

EC 2.3.2.31

NP_899645.1

EC 2.3.2.31

NP_899646.1

EC 2.3.2.31

NP_899647.1

EC 2.3.2.31

NP_899648.1

EC 2.3.2.31

XP_011536016.1

EC 2.3.2.31

XP_016865563.1

EC 2.3.2.31

XP_016865564.1

EC 2.3.2.31

XP_024302033.1

EC 2.3.2.31

XP_047273854.1

EC 2.3.2.31

XP_047273855.1

EC 2.3.2.31

XP_047273856.1

EC 2.3.2.31

XP_047273857.1

EC 2.3.2.31

XP_047273858.1

EC 2.3.2.31

XP_047273859.1

EC 2.3.2.31

XP_047273860.1

EC 2.3.2.31

XP_047273861.1

EC 2.3.2.31

XP_047273862.1

EC 2.3.2.31

XP_047273863.1

EC 2.3.2.31

XP_047273864.1

EC 2.3.2.31

XP_047273865.1

EC 2.3.2.31

XP_047273866.1

EC 2.3.2.31

XP_054209813.1

EC 2.3.2.31

XP_054209814.1

EC 2.3.2.31

XP_054209815.1

EC 2.3.2.31

XP_054209816.1

EC 2.3.2.31

XP_054209817.1

EC 2.3.2.31

XP_054209818.1

EC 2.3.2.31

XP_054209819.1

EC 2.3.2.31

XP_054209820.1

EC 2.3.2.31

XP_054209821.1

EC 2.3.2.31

XP_054209822.1

EC 2.3.2.31

XP_054209823.1

EC 2.3.2.31

XP_054209824.1

EC 2.3.2.31

XP_054209825.1

EC 2.3.2.31

XP_054209826.1

EC 2.3.2.31

XP_054209827.1

EC 2.3.2.31

XP_054209828.1

EC 2.3.2.31

XP_054209829.1

EC 2.3.2.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001201365.2 → NP_001188294.1 E3 ubiquitin-protein ligase RNF14 isoform 1

See identical proteins and their annotated locations for NP_001188294.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Both variants encode the same isoform (1).

Source sequence(s)

AC005740, BC126185, BE042895, DC396586

Consensus CDS

CCDS4270.1

UniProtKB/Swiss-Prot

A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8

UniProtKB/TrEMBL

B3KN55

Related

ENSP00000378027.1, ENST00000394519.5

Conserved Domains (4) summary

smart00647
Location:289 → 350

IBR; In Between Ring fingers

pfam01485
Location:377 → 433

IBR; IBR domain, a half RING-finger domain

pfam05773
Location:7 → 133

RWD; RWD domain

cd16628
Location:218 → 271

RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
NM_004290.5 → NP_004281.1 E3 ubiquitin-protein ligase RNF14 isoform 1

See identical proteins and their annotated locations for NP_004281.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AC005740, AF060544, BE042895, DC402536

Consensus CDS

CCDS4270.1

UniProtKB/Swiss-Prot

A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8

UniProtKB/TrEMBL

B3KN55

Related

ENSP00000378028.2, ENST00000394520.7

Conserved Domains (4) summary

smart00647
Location:289 → 350

IBR; In Between Ring fingers

pfam01485
Location:377 → 433

IBR; IBR domain, a half RING-finger domain

pfam05773
Location:7 → 133

RWD; RWD domain

cd16628
Location:218 → 271

RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
NM_183398.3 → NP_899645.1 E3 ubiquitin-protein ligase RNF14 isoform 2

See identical proteins and their annotated locations for NP_899645.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon compared to variant 1. The translation begins at a downstream start codon and results in an isoform (2) that has a shorter N-terminus, as compared to isoform 1.

Source sequence(s)

AC005740, AF060544, BE042895, DB456366, DC402536

Consensus CDS

CCDS4271.1

UniProtKB/Swiss-Prot

Q9UBS8

Related

ENSP00000378022.2, ENST00000394514.6

Conserved Domains (3) summary

smart00647
Location:163 → 224

IBR; In Between Ring fingers

cd16628
Location:92 → 145

RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins

pfam01485
Location:251 → 307

IBR; IBR domain, a half RING-finger domain
NM_183399.3 → NP_899646.1 E3 ubiquitin-protein ligase RNF14 isoform 1

See identical proteins and their annotated locations for NP_899646.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants encode the same isoform (1).

Source sequence(s)

AC005740, AF060544, BE042895, DC396586

Consensus CDS

CCDS4270.1

UniProtKB/Swiss-Prot

A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8

UniProtKB/TrEMBL

B3KN55

Related

ENSP00000348462.1, ENST00000356143.5

Conserved Domains (4) summary

smart00647
Location:289 → 350

IBR; In Between Ring fingers

pfam01485
Location:377 → 433

IBR; IBR domain, a half RING-finger domain

pfam05773
Location:7 → 133

RWD; RWD domain

cd16628
Location:218 → 271

RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
NM_183400.3 → NP_899647.1 E3 ubiquitin-protein ligase RNF14 isoform 1

See identical proteins and their annotated locations for NP_899647.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks a segment within the 5' UTR compared to variant 1. Both variants encode the same isoform (1).

Source sequence(s)

AC005740, AF060544, BE042895, DC402536

Consensus CDS

CCDS4270.1

UniProtKB/Swiss-Prot

A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8

UniProtKB/TrEMBL

B3KN55

Related

ENSP00000324956.3, ENST00000347642.7

Conserved Domains (4) summary

smart00647
Location:289 → 350

IBR; In Between Ring fingers

pfam01485
Location:377 → 433

IBR; IBR domain, a half RING-finger domain

pfam05773
Location:7 → 133

RWD; RWD domain

cd16628
Location:218 → 271

RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
NM_183401.3 → NP_899648.1 E3 ubiquitin-protein ligase RNF14 isoform 1

See identical proteins and their annotated locations for NP_899648.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Both variants encode the same isoform (1).

Source sequence(s)

AC005740, AF060544, BE042895, DC358984

Consensus CDS

CCDS4270.1

UniProtKB/Swiss-Prot

A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8

UniProtKB/TrEMBL

B3KN55

Conserved Domains (4) summary

smart00647
Location:289 → 350

IBR; In Between Ring fingers

pfam01485
Location:377 → 433

IBR; IBR domain, a half RING-finger domain

pfam05773
Location:7 → 133

RWD; RWD domain

cd16628
Location:218 → 271

RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

141949337..141990292

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047417908.1 → XP_047273864.1 E3 ubiquitin-protein ligase RNF14 isoform X2

UniProtKB/TrEMBL

B7Z229
XM_047417904.1 → XP_047273860.1 E3 ubiquitin-protein ligase RNF14 isoform X1

UniProtKB/Swiss-Prot

A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
XM_047417903.1 → XP_047273859.1 E3 ubiquitin-protein ligase RNF14 isoform X1

UniProtKB/Swiss-Prot

A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
XM_047417899.1 → XP_047273855.1 E3 ubiquitin-protein ligase RNF14 isoform X1

UniProtKB/Swiss-Prot

A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
XM_047417907.1 → XP_047273863.1 E3 ubiquitin-protein ligase RNF14 isoform X2

UniProtKB/TrEMBL

B7Z229
XM_047417898.1 → XP_047273854.1 E3 ubiquitin-protein ligase RNF14 isoform X1

UniProtKB/Swiss-Prot

A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
XM_047417906.1 → XP_047273862.1 E3 ubiquitin-protein ligase RNF14 isoform X2

UniProtKB/TrEMBL

B7Z229
XM_047417905.1 → XP_047273861.1 E3 ubiquitin-protein ligase RNF14 isoform X1

UniProtKB/Swiss-Prot

A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
XM_047417909.1 → XP_047273865.1 E3 ubiquitin-protein ligase RNF14 isoform X2

UniProtKB/TrEMBL

B7Z229
XM_024446265.2 → XP_024302033.1 E3 ubiquitin-protein ligase RNF14 isoform X2

UniProtKB/TrEMBL

B7Z229

Conserved Domains (3) summary

smart00647
Location:113 → 174

IBR; In Between Ring fingers

pfam01485
Location:201 → 257

IBR; IBR domain, a half RING-finger domain

cl02687
Location:7 → 79

RWD; RWD domain
XM_047417902.1 → XP_047273858.1 E3 ubiquitin-protein ligase RNF14 isoform X1

UniProtKB/Swiss-Prot

A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
XM_017010075.3 → XP_016865564.1 E3 ubiquitin-protein ligase RNF14 isoform X2

UniProtKB/TrEMBL

B7Z229

Conserved Domains (3) summary

smart00647
Location:113 → 174

IBR; In Between Ring fingers

pfam01485
Location:201 → 257

IBR; IBR domain, a half RING-finger domain

cl02687
Location:7 → 79

RWD; RWD domain
XM_047417900.1 → XP_047273856.1 E3 ubiquitin-protein ligase RNF14 isoform X1

UniProtKB/Swiss-Prot

A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
XM_047417901.1 → XP_047273857.1 E3 ubiquitin-protein ligase RNF14 isoform X1

UniProtKB/Swiss-Prot

A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
XM_011537714.4 → XP_011536016.1 E3 ubiquitin-protein ligase RNF14 isoform X1

See identical proteins and their annotated locations for XP_011536016.1

UniProtKB/Swiss-Prot

A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8

UniProtKB/TrEMBL

B3KN55

Conserved Domains (4) summary

smart00647
Location:289 → 350

IBR; In Between Ring fingers

pfam01485
Location:377 → 433

IBR; IBR domain, a half RING-finger domain

pfam05773
Location:7 → 133

RWD; RWD domain

cd16628
Location:218 → 271

RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
XM_047417910.1 → XP_047273866.1 E3 ubiquitin-protein ligase RNF14 isoform X2

UniProtKB/TrEMBL

B7Z229
XM_017010074.3 → XP_016865563.1 E3 ubiquitin-protein ligase RNF14 isoform X2

UniProtKB/TrEMBL

B7Z229

Conserved Domains (3) summary

smart00647
Location:113 → 174

IBR; In Between Ring fingers

pfam01485
Location:201 → 257

IBR; IBR domain, a half RING-finger domain

cl02687
Location:7 → 79

RWD; RWD domain