rab10 RAB10, member RAS oncogene family [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rab10provided by ZNC
Official Full Name: RAB10, member RAS oncogene familyprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-304
See related: Ensembl:ENSDARG00000046106 AllianceGenome:ZFIN:ZDB-GENE-040718-304
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92757
Summary: Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within axon development. Predicted to be active in Golgi apparatus; cytoplasmic vesicle; and plasma membrane. Orthologous to human RAB10 (RAB10, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (47434709..47471621)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (47540141..47577051, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab10 interaction with myosin Vb (MYO5B) determines the formation of Rab10 carriers and is important for axon development.
Title: Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development.

Submit: New GeneRIF Correction

General gene information

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Markers

fe05f12.x1 (e-PCR)
- UniSTS:195993

fe49e05.y1 (e-PCR)
- UniSTS:196549

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables myosin V binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in localization within membrane	IEA Inferred from Electronic Annotation more info
involved_in protein secretion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane bounded cell projection	IEA Inferred from Electronic Annotation more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in secretory vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ras-related protein Rab-10

NP_001002566.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002566.1 → NP_001002566.1 ras-related protein Rab-10

See identical proteins and their annotated locations for NP_001002566.1

Status: PROVISIONAL

Source sequence(s)

BC076234

UniProtKB/TrEMBL

A0A8M1N0P6, Q6DGV5

Related

ENSDARP00000067775.3, ENSDART00000067776.4

Conserved Domains (2) summary

smart00175
Location:10 → 173

RAB; Rab subfamily of small GTPases

cd01867
Location:7 → 173

Rab8_Rab10_Rab13_like; Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)