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    Crybg3 crystallin beta-gamma domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288204, updated on 11-Apr-2024

    Summary

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    Symbol
    Crybg3provided by RGD
    Full Name
    crystallin beta-gamma domain containing 3provided by RGD
    Primary source
    RGD:1305628
    See related
    Ensembl:ENSRNOG00000045728 AllianceGenome:RGD:1305628
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305628; AABR07033887.1
    Summary
    Predicted to enable protein kinase A binding activity. Predicted to be a structural constituent of eye lens. Predicted to be involved in lens development in camera-type eye and visual perception. Predicted to be part of protein-containing complex. Orthologous to human CRYBG3 (crystallin beta-gamma domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 321.6), Lung (RPKM 163.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    11q12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (54218399..54330962)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (40749198..40861753)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (42895610..43006568)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene Eph receptor A6 Neighboring gene U7 small nuclear RNA Neighboring gene ADP-ribosylation factor like GTPase 6 Neighboring gene NLR family, pyrin domain containing 4A, pseudogene 1 Neighboring gene uncharacterized LOC134480985 Neighboring gene ribosomal oxygenase 2 Neighboring gene gamma-aminobutyric acid type A receptor subunit rho3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A systematic evaluation of protein kinase A-A-kinase anchoring protein interaction motifs. Burgers PP, et al. Biochemistry, 2015 Jan 13. PMID 25097019
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of eye lens IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lens development in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in visual perception IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    beta/gamma crystallin domain-containing protein 3; very large A-kinase anchor protein
    Names
    beta-gamma crystallin domain containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      54218399..54330962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_213639.11 → XP_213639.6  very large A-kinase anchor protein

      See identical proteins and their annotated locations for XP_213639.6

      UniProtKB/TrEMBL
      A0A8I6A3B0, M0RDY6
      Related
      ENSRNOP00000067850.3
      Conserved Domains (3) summary
      cd00161
      Location:2820 → 2949
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00030
      Location:2556 → 2637
      Crystall; Beta/Gamma crystallin
      pfam00652
      Location:2821 → 2947
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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