Rdx radixin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rdxprovided by RGD
Official Full Name: radixinprovided by RGD
Primary source: RGD:1359472
See related: Ensembl:ENSRNOG00000012237 AllianceGenome:RGD:1359472
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables actin binding activity. Involved in apical protein localization; barbed-end actin filament capping; and cellular response to platelet-derived growth factor stimulus. Located in several cellular components, including T-tubule; cleavage furrow; and midbody. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 24. Orthologous to human RDX (radixin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 695.8), Lung (RPKM 608.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (61275792..61348260)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (52379494..52437673)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (56570728..56612851)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Changes in Radixin Expression and Interaction with Efflux Transporters in the Liver of Adjuvant-Induced Arthritic Rats.
Title: Changes in Radixin Expression and Interaction with Efflux Transporters in the Liver of Adjuvant-Induced Arthritic Rats.
Overexpression ezrin, radixin and moesin facilitates influenza virus H1N1 replication in primary pulmonary microvascular endothelial cells.
Title: [The transfection of lentiviral siRNA vectors targeting ezrin, radixin and moesin facilitates influenza virus replication in primary pulmonary microvascular endothelial cells].
These results indicate that ezrin, radixin, and moesin exert a redundant control on platelet derived growth factor-induced vascular smooth muscle cells migration by regulating focal adhesion turn-over and cell adhesion to substrate.
Title: Redundant control of migration and adhesion by ERM proteins in vascular smooth muscle cells.
The ERM (ezrin, radixin, moesin) proteins are novel scaffolds at the level of SOS activity control, which is relevant for both normal Ras function and dysfunction known to occur in several human cancers.
Title: Activation of Ras requires the ERM-dependent link of actin to the plasma membrane.
Lipopolysaccharide-induced cholestasis seems to be caused by posttranscriptional regulation of Mrp2, which is due to the disruption of its interaction with radixin and by its dephosphorylation.
Title: LPS-induced dissociation of multidrug resistance-associated protein 2 (Mrp2) and radixin is associated with Mrp2 selective internalization in rats.
Data show that Hyal2, through direct interactions with CD44 and possibly some pericellular hyaluronidase activity suppresses the formation or the stability of the glycocalyx, modulates ERM-related cytoskeletal interactions, and diminishes cell motility.
Title: Two novel functions of hyaluronidase-2 (Hyal2) are formation of the glycocalyx and control of CD44-ERM interactions.
Activated ERM proteins mediate the effects of acid-induced NHE1 activation in left ventricular myocytes.
Title: ERM proteins mediate the effects of Na+/H+ exchanger (NHE1) activation in cardiac myocytes.
bile salt-induced cholestasis is associated with changes of the actin cytoskeleton and actin binding protein radixin and a retrieval of the canalicular export pump Mrp2
Title: Retrieval of the rat canalicular conjugate export pump Mrp2 is associated with a rearrangement of actin filaments and radixin in bile salt-induced cholestasis.
Activation of Ezrin/Radixin/Moesin proteins at the Schwann cell process tip is essential for motility and the maintenance of polarity.
Title: Asymmetric ERM activation at the Schwann cell process tip is required in axon-associated motility.
Radixin is predominant membrane-cytoskeletal linker for L1 during migration and axon extension, neither of which requires ankyrin function.
Title: ERMs colocalize transiently with L1 during neocortical axon outgrowth.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143457 (e-PCR)
- UniSTS:232704

AA965233 (e-PCR)
- UniSTS:248629

RH124276 (e-PCR)
- UniSTS:161098

EST5F4 (e-PCR)
- UniSTS:263387

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in apical protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apical protein localization	ISO Inferred from Sequence Orthology more info
involved_in barbed-end actin filament capping	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to platelet-derived growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to thyroid hormone stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to thyroid hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microvillus assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adherens junction organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of homotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of early endosome to late endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to early endosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein localization to early endosome	ISO Inferred from Sequence Orthology more info
involved_in protein kinase A signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of Rap protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in regulation of organelle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of organelle assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping	ISO Inferred from Sequence Orthology more info
involved_in regulation of ruffle assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical part of cell	IBA Inferred from Biological aspect of Ancestor more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell tip	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
located_in cortical actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in filopodium	IBA Inferred from Biological aspect of Ancestor more info
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in stereocilium	ISO Inferred from Sequence Orthology more info
located_in stereocilium base	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: radixin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005889.2 → NP_001005889.2 radixin

See identical proteins and their annotated locations for NP_001005889.2

Status: PROVISIONAL

Source sequence(s)

BC087147

UniProtKB/TrEMBL

A0A8I5Y0V6, Q5PQK5, Q5WQV5

Related

ENSRNOP00000077207.1, ENSRNOT00000117679.1

Conserved Domains (5) summary

smart00295
Location:7 → 206

B41; Band 4.1 homologues

cd13194
Location:200 → 296

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00373
Location:91 → 206

FERM_M; FERM central domain

pfam00769
Location:347 → 583

ERM; Ezrin/radixin/moesin family

pfam09379
Location:9 → 71

FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

61275792..61348260

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063265453.1 → XP_063121523.1 radixin isoform X1

UniProtKB/TrEMBL

E9PT65
XM_039081453.2 → XP_038937381.1 radixin isoform X1

UniProtKB/TrEMBL

E9PT65, Q5WQV5

Related

ENSRNOP00000035840.5

Conserved Domains (3) summary

smart00295
Location:7 → 206

B41; Band 4.1 homologues

cd13194
Location:200 → 296

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:347 → 583

ERM; Ezrin/radixin/moesin family
XM_063265455.1 → XP_063121525.1 radixin isoform X2
XM_063265456.1 → XP_063121526.1 radixin isoform X2
XM_039081455.2 → XP_038937383.1 radixin isoform X2

UniProtKB/TrEMBL

Q5WQV5

Conserved Domains (3) summary

smart00295
Location:7 → 206

B41; Band 4.1 homologues

cd13194
Location:200 → 296

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:347 → 582

ERM; Ezrin/radixin/moesin family
XM_039081456.2 → XP_038937384.1 radixin isoform X3

UniProtKB/TrEMBL

T1SRT4

Conserved Domains (2) summary

smart00295
Location:7 → 206

B41; Band 4.1 homologues

cd13194
Location:200 → 296

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
XM_063265459.1 → XP_063121529.1 radixin isoform X3

UniProtKB/TrEMBL

T1SRT4
XM_063265454.1 → XP_063121524.1 radixin isoform X1

UniProtKB/TrEMBL

E9PT65
XM_039081452.2 → XP_038937380.1 radixin isoform X1

UniProtKB/TrEMBL

E9PT65, Q5WQV5

Conserved Domains (3) summary

smart00295
Location:7 → 206

B41; Band 4.1 homologues

cd13194
Location:200 → 296

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:347 → 583

ERM; Ezrin/radixin/moesin family