adgrl3.1 adhesion G protein-coupled receptor L3.1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adgrl3.1provided by ZNC
Official Full Name: adhesion G protein-coupled receptor L3.1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7856
See related: Ensembl:ENSDARG00000061121 AllianceGenome:ZFIN:ZDB-GENE-030131-7856
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lphn3; lphn3.1; wu:fj36g07; si:ch211-209p5.2
Summary: Predicted to enable G protein-coupled receptor activity and carbohydrate binding activity. Acts upstream of or within cellular response to estrogen stimulus and locomotory behavior. Predicted to be located in axon and plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including central nervous system; eye; heart; liver; and ovary. Orthologous to human ADGRL3 (adhesion G protein-coupled receptor L3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 1

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (22943546..23157716, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (22252810..22467012, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study found that lphn3.1 morphants have an overall hyposensitivity to dopamine agonists and antagonists compared to control fish. These results are compatible with a model whereby dopaminergic neurotransmission is saturated in lphn3.1 morphants.
Title: Pharmacological analysis of zebrafish lphn3.1 morphant larvae suggests that saturated dopaminergic signaling could underlie the ADHD-like locomotor hyperactivity.
results implicate decreased Lphn3 activity in eliciting ADHD-like behavior, and demonstrate its correlated contribution to the development of the brain dopaminergic circuitry
Title: The ADHD-susceptibility gene lphn3.1 modulates dopaminergic neuron formation and locomotor activity during zebrafish development.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fj36g07.x1 (e-PCR)
- UniSTS:199222

G47480 (e-PCR)
- UniSTS:108256

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to estrogen stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: latrophilin-3; adhesion G protein-coupled receptor L3

Names: latrophilin 3; latrophilin 3.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

22943546..23157716 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005170941.4 → XP_005170998.1 adhesion G protein-coupled receptor L3 isoform X2

UniProtKB/TrEMBL

A0A8M2BI50

Conserved Domains (7) summary

smart00284
Location:160 → 415

OLF; Olfactomedin-like domains

smart00303
Location:806 → 858

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:493 → 553

HormR; Domain present in hormone receptors

pfam00002
Location:867 → 1102

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02140
Location:66 → 146

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1123 → 1539

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:562 → 780

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
XM_684028.9 → XP_689120.5 adhesion G protein-coupled receptor L3 isoform X5

UniProtKB/TrEMBL

A0A2R8Q6E9, A0A8N7UUV2

Related

ENSDARP00000148668.1, ENSDART00000189344.1

Conserved Domains (7) summary

smart00284
Location:160 → 415

OLF; Olfactomedin-like domains

smart00303
Location:807 → 859

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:493 → 553

HormR; Domain present in hormone receptors

pfam00002
Location:868 → 1103

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02140
Location:66 → 146

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1124 → 1492

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:562 → 780

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
XM_021476346.1 → XP_021332021.1 adhesion G protein-coupled receptor L3 isoform X4

UniProtKB/TrEMBL

A0A8M9Q934

Conserved Domains (9) summary

smart00284
Location:160 → 415

OLF; Olfactomedin-like domains

smart00303
Location:807 → 859

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:493 → 553

HormR; Domain present in hormone receptors

pfam02140
Location:66 → 146

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1124 → 1498

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:562 → 782

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cd14964
Location:870 → 894

7tm_GPCRs; TM helix 1 [structural motif]

cl26464
Location:424 → 539

Atrophin-1; Atrophin-1 family

cl28897
Location:867 → 1124

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_005170942.4 → XP_005170999.1 adhesion G protein-coupled receptor L3 isoform X3

UniProtKB/TrEMBL

A0A8M2BI94, F1Q579

Related

ENSDARP00000081231.6, ENSDART00000086797.6

Conserved Domains (7) summary

smart00284
Location:160 → 415

OLF; Olfactomedin-like domains

smart00303
Location:807 → 859

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:493 → 553

HormR; Domain present in hormone receptors

pfam00002
Location:868 → 1103

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02140
Location:66 → 146

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1124 → 1534

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:562 → 780

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
XM_005170940.4 → XP_005170997.1 adhesion G protein-coupled receptor L3 isoform X1

UniProtKB/TrEMBL

A0A2R8QM07, A0A8M2BIN7

Related

ENSDARP00000156478.1, ENSDART00000190858.1

Conserved Domains (7) summary

smart00284
Location:160 → 415

OLF; Olfactomedin-like domains

smart00303
Location:807 → 859

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:493 → 553

HormR; Domain present in hormone receptors

pfam00002
Location:868 → 1103

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02140
Location:66 → 146

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1124 → 1540

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:562 → 780

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain