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    Macrod2 mono-ADP ribosylhydrolase 2 [ Mus musculus (house mouse) ]

    Gene ID: 72899, updated on 4-May-2024

    Summary

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    Official Symbol
    Macrod2provided by MGI
    Official Full Name
    mono-ADP ribosylhydrolase 2provided by MGI
    Primary source
    MGI:MGI:1920149
    See related
    Ensembl:ENSMUSG00000068205 AllianceGenome:MGI:1920149
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110033L15Rik; 2610107G07Rik; 2900006F19Rik
    Summary
    Predicted to enable ADP-ribosylglutamate hydrolase activity and deacetylase activity. Acts upstream of or within brain development and response to bacterium. Predicted to be located in nucleolus. Predicted to be active in nucleoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and sensory organ. Orthologous to human MACROD2 (mono-ADP ribosylhydrolase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 2.9), frontal lobe adult (RPKM 2.4) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 F3- G1; 2 69.2 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (140237223..142234886)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (140395303..142392966)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05847 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 5 Neighboring gene predicted gene, 52594 Neighboring gene STARR-positive B cell enhancer mm9_chr2:140253034-140253335 Neighboring gene sel-1 suppressor of lin-12-like 2 (C. elegans) Neighboring gene STARR-seq mESC enhancer starr_05848 Neighboring gene STARR-seq mESC enhancer starr_05850 Neighboring gene predicted gene, 23846 Neighboring gene STARR-seq mESC enhancer starr_05851 Neighboring gene STARR-seq mESC enhancer starr_05853 Neighboring gene fibronectin leucine rich transmembrane protein 3 Neighboring gene STARR-seq mESC enhancer starr_05855 Neighboring gene STARR-seq mESC enhancer starr_05856 Neighboring gene zinc finger, CCHC domain containing 9, pseudogene Neighboring gene STARR-seq mESC enhancer starr_05857 Neighboring gene mono-ADP ribosylhydrolase 2, opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_05858 Neighboring gene STARR-seq mESC enhancer starr_05859 Neighboring gene STARR-seq mESC enhancer starr_05861 Neighboring gene STARR-seq mESC enhancer starr_05862 Neighboring gene predicted gene, 25583 Neighboring gene STARR-seq mESC enhancer starr_05863 Neighboring gene STARR-seq mESC enhancer starr_05864 Neighboring gene Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived), pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_05865 Neighboring gene STARR-seq mESC enhancer starr_05866 Neighboring gene STARR-seq mESC enhancer starr_05867 Neighboring gene STARR-seq mESC enhancer starr_05871 Neighboring gene STARR-seq mESC enhancer starr_05872 Neighboring gene STARR-seq mESC enhancer starr_05873 Neighboring gene ribosomal protein L26, pseudogene 5 Neighboring gene RNA binding motif protein, X-linked 2, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mono-ADP-Ribosylhydrolase MACROD2 Is Dispensable for Murine Responses to Metabolic and Genotoxic Insults. Lo Re O, et al. Front Genet, 2018. PMID 30619475, Free PMC Article
    2. Behavioural Characterisation of Macrod1 and Macrod2 Knockout Mice. Crawford K, et al. Cells, 2021 Feb 10. PMID 33578760, Free PMC Article
    3. The C20orf133 gene is disrupted in a patient with Kabuki syndrome. Maas NM, et al. J Med Genet, 2007 Sep. PMID 17586838, Free PMC Article
    4. Biochemical and Morphological Characterization of a Neurodevelopmental Disorder-Related Mono-ADP-Ribosylhydrolase, MACRO Domain Containing 2. Ito H, et al. Dev Neurosci, 2018. PMID 30227424
    5. MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors. Sakthianandeswaren A, et al. Cancer Discov, 2018 Aug. PMID 29880585

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Behavioural Characterisation of Macrod1 and Macrod2 Knockout Mice.
      Title: Behavioural Characterisation of Macrod1 and Macrod2 Knockout Mice.
    2. MacroD2 is expressed and may have a physiological role in the central nervous system during brain development
      Title: Biochemical and Morphological Characterization of a Neurodevelopmental Disorder-Related Mono-ADP-Ribosylhydrolase, MACRO Domain Containing 2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC100276

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ADP-ribosylglutamate hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ADP-ribosylglutamate hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in brain development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in peptidyl-glutamate ADP-deribosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-glutamate ADP-deribosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein de-ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in purine nucleoside metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleoside metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribose glycohydrolase MACROD2
    Names
    MACRO domain containing 2
    MACRO domain-containing protein 2
    O-acetyl-ADP-ribose deacetylase MACROD2
    [Protein ADP-ribosylaspartate] hydrolase MACROD2
    [Protein ADP-ribosylglutamate] hydrolase
    [Protein ADP-ribosylglutamate] hydrolase MACROD2
    NP_001013824.2
    NP_001393313.1
    NP_001393314.1
    NP_001393315.1
    NP_001393316.1
    NP_001393317.1
    NP_001393318.1
    NP_001393319.1
    NP_001393320.1
    NP_001393321.1
    NP_001393322.1
    NP_001393323.1
    NP_001393324.1
    NP_001393325.1
    NP_001393326.1
    NP_001393327.1
    NP_082663.1
    XP_006500314.1
    XP_006500316.1
    XP_011238096.1
    XP_017174774.1
    XP_036018502.1
    XP_036018504.1
    XP_036018505.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013802.4 → NP_001013824.2  ADP-ribose glycohydrolase MACROD2 isoform 1

      See identical proteins and their annotated locations for NP_001013824.2

      Status: VALIDATED

      Source sequence(s)
      AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443
      Consensus CDS
      CCDS50733.1
      UniProtKB/Swiss-Prot
      Q3UYG8
      UniProtKB/TrEMBL
      A2AS33
      Related
      ENSMUSP00000105691.2, ENSMUST00000110064.8
      Conserved Domains (2) summary
      COG2110
      Location:70 → 239
      YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
      cd02908
      Location:71 → 237
      Macro_Appr_pase_like; Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...

    2. NM_001406384.1 → NP_001393313.1  ADP-ribose glycohydrolase MACROD2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443

    3. NM_001406385.1 → NP_001393314.1  ADP-ribose glycohydrolase MACROD2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443

    4. NM_001406386.1 → NP_001393315.1  ADP-ribose glycohydrolase MACROD2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443

    5. NM_001406387.1 → NP_001393316.1  ADP-ribose glycohydrolase MACROD2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443

    6. NM_001406388.1 → NP_001393317.1  ADP-ribose glycohydrolase MACROD2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443

    7. NM_001406389.1 → NP_001393318.1  ADP-ribose glycohydrolase MACROD2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443

    8. NM_001406390.1 → NP_001393319.1  ADP-ribose glycohydrolase MACROD2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443

    9. NM_001406391.1 → NP_001393320.1  ADP-ribose glycohydrolase MACROD2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443

    10. NM_001406392.1 → NP_001393321.1  ADP-ribose glycohydrolase MACROD2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443

    11. NM_001406393.1 → NP_001393322.1  ADP-ribose glycohydrolase MACROD2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443
      Related
      ENSMUSP00000105694.2, ENSMUST00000110067.8

    12. NM_001406394.1 → NP_001393323.1  ADP-ribose glycohydrolase MACROD2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443

    13. NM_001406395.1 → NP_001393324.1  ADP-ribose glycohydrolase MACROD2 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL731795, AL837516, AL844562, AL844582, AL845530, AL929027, AL929443

    14. NM_001406396.1 → NP_001393325.1  ADP-ribose glycohydrolase MACROD2 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AL731795, AL928700, AL929027
      UniProtKB/TrEMBL
      B1AW12
      Related
      ENSMUSP00000105690.2, ENSMUST00000110063.8

    15. NM_001406397.1 → NP_001393326.1  ADP-ribose glycohydrolase MACROD2 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AL731795, AL928700, AL929027
      Related
      ENSMUST00000154505.8

    16. NM_001406398.1 → NP_001393327.1  ADP-ribose glycohydrolase MACROD2 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AL731795, AL928700, AL929027

    17. NM_028387.2 → NP_082663.1  ADP-ribose glycohydrolase MACROD2 isoform 2

      See identical proteins and their annotated locations for NP_082663.1

      Status: VALIDATED

      Source sequence(s)
      AL731795
      Consensus CDS
      CCDS16805.1
      UniProtKB/TrEMBL
      Q9D117
      Related
      ENSMUSP00000041780.8, ENSMUST00000043836.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      140237223..142234886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162611.1 → XP_036018504.1  ADP-ribose glycohydrolase MACROD2 isoform X14

      UniProtKB/TrEMBL
      A2AS33
      Conserved Domains (1) summary
      cd02908
      Location:71 → 237
      Macro_OAADPr_deacetylase; macrodomain, O-acetyl-ADP-ribose (OAADPr) family

    2. XM_006500251.3 → XP_006500314.1  ADP-ribose glycohydrolase MACROD2 isoform X11

      UniProtKB/TrEMBL
      A2AS33
      Conserved Domains (2) summary
      COG5271
      Location:243 → 430
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      PRK00431
      Location:71 → 239
      PRK00431; ADP-ribose-binding protein

    3. XM_011239794.2 → XP_011238096.1  ADP-ribose glycohydrolase MACROD2 isoform X8

      UniProtKB/TrEMBL
      A2AS33
      Conserved Domains (1) summary
      cl00019
      Location:71 → 200
      Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...

    4. XM_036162609.1 → XP_036018502.1  ADP-ribose glycohydrolase MACROD2 isoform X9

      UniProtKB/TrEMBL
      A2AS33
      Conserved Domains (2) summary
      cd02908
      Location:71 → 198
      Macro_OAADPr_deacetylase; macrodomain, O-acetyl-ADP-ribose (OAADPr) family
      NF033845
      Location:289 → 430
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    5. XM_036162612.1 → XP_036018505.1  ADP-ribose glycohydrolase MACROD2 isoform X16

      UniProtKB/TrEMBL
      A2AS33
      Conserved Domains (2) summary
      cd02908
      Location:71 → 198
      Macro_OAADPr_deacetylase; macrodomain, O-acetyl-ADP-ribose (OAADPr) family
      NF033845
      Location:205 → 417
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    6. XM_017319285.2 → XP_017174774.1  ADP-ribose glycohydrolase MACROD2 isoform X13

      UniProtKB/TrEMBL
      A2AS33
      Conserved Domains (1) summary
      cl00019
      Location:70 → 189
      Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...

    7. XM_006500253.3 → XP_006500316.1  ADP-ribose glycohydrolase MACROD2 isoform X15

      Related
      ENSMUST00000138786.2
      Conserved Domains (1) summary
      cl00019
      Location:42 → 184
      Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UYG8.1 GenPept UniProtKB/Swiss-Prot:Q3UYG8

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