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    Zfp689 zinc finger protein 689 [ Mus musculus (house mouse) ]

    Gene ID: 71131, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Zfp689provided by MGI
    Official Full Name
    zinc finger protein 689provided by MGI
    Primary source
    MGI:MGI:1918381
    See related
    Ensembl:ENSMUSG00000048921 AllianceGenome:MGI:1918381
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf689; 4933416E05Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within skeletal muscle cell differentiation. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and respiratory system. Orthologous to human ZNF689 (zinc finger protein 689). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 5.6), limb E14.5 (RPKM 4.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F3; 7 69.53 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127041308..127048330, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127442136..127449158, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene myeloma-overexpressed gene 2 protein homolog Neighboring gene STARR-seq mESC enhancer starr_20181 Neighboring gene zinc finger protein 688 Neighboring gene RIKEN cDNA B130055M24 gene Neighboring gene STARR-positive B cell enhancer ABC_E1095 Neighboring gene STARR-seq mESC enhancer starr_20182 Neighboring gene STARR-seq mESC enhancer starr_20183 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134614302-134614485 Neighboring gene STARR-positive B cell enhancer ABC_E1742 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134621461-134621644 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134621862-134622045 Neighboring gene proline rich 14 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134623956-134624143 Neighboring gene fibrosin Neighboring gene microRNA 7060

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Rajan S, et al. Physiol Genomics, 2012 Feb 1. PMID 22147266
    2. Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Memic F, et al. Gastroenterology, 2018 Feb. PMID 29031500, Free PMC Article
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 689

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175163.3 → NP_780372.2  zinc finger protein 689

      See identical proteins and their annotated locations for NP_780372.2

      Status: VALIDATED

      Source sequence(s)
      AC136146, AK028417, AK051667, BB570116, BU054587, CO041951
      Consensus CDS
      CCDS21867.1
      UniProtKB/Swiss-Prot
      Q8BKK5, Q8C1C6
      Related
      ENSMUSP00000056610.5, ENSMUST00000053392.11
      Conserved Domains (5) summary
      smart00349
      Location:29 → 88
      KRAB; krueppel associated box
      COG5048
      Location:171 → 466
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:29 → 68
      KRAB; KRAB box
      pfam13465
      Location:303 → 328
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      127041308..127048330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BKK5.1 GenPept UniProtKB/Swiss-Prot:Q8BKK5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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