CERNA1 competing endogenous lncRNA 1 for miR-4707-5p and miR-4767 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CERNA1provided by HGNC
Official Full Name: competing endogenous lncRNA 1 for miR-4707-5p and miR-4767provided by HGNC
Primary source: HGNC:HGNC:52664
See related: AllianceGenome:HGNC:52664
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression: Ubiquitous expression in thyroid (RPKM 3.8), lung (RPKM 2.9) and 25 other tissues See more
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Genomic context

Location:: 15q21.2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (52180026..52205879)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (49988681..50014493)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (52472223..52498076)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nuclear long noncoding RNA CERNA1 positively regulates BCL2-like 10 (apoptosis facilitator) protein, which accelerates the serum and FGF-2 starvation-induced apoptosis of vascular endothelial cells (VECs). Annexin A7 inhibitor, ABO (6-amino-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine), increases the expression of CERNA1 and improves its cytoplasm distribution proportion so as to inhibit the apoptosis of VECs.
Title: Effects of annexin A7 inhibitor-ABO on the expression and distribution of long noncoding RNA-CERNA1 in vascular endothelial cells apoptosis.
Study provides evidence that Long Noncoding RNA LOC100129973 suppresses apoptosis by targeting miR-4707-5p and miR-4767 in vascular endothelial cells.
Title: Long Noncoding RNA LOC100129973 Suppresses Apoptosis by Targeting miR-4707-5p and miR-4767 in Vascular Endothelial Cells.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

A003P09 (e-PCR)
- UniSTS:11634

STS-AA004803 (e-PCR)
- UniSTS:31674

RH45438 (e-PCR)
- UniSTS:9930

G44711 (e-PCR)
- UniSTS:95186

RH103431 (e-PCR)
- UniSTS:97756

A008V02 (e-PCR)
- UniSTS:54769

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.