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    Lrp2bp Lrp2 binding protein [ Mus musculus (house mouse) ]

    Gene ID: 67620, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Lrp2bpprovided by MGI
    Official Full Name
    Lrp2 binding proteinprovided by MGI
    Primary source
    MGI:MGI:1914870
    See related
    Ensembl:ENSMUSG00000031637 AllianceGenome:MGI:1914870
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MegBP; 1700113N17Rik; 2310006J04Rik; 4930479L12Rik
    Summary
    Predicted to be located in cytoplasm. Orthologous to human LRP2BP (LRP2 binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 11.2) and mammary gland adult (RPKM 0.3) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 B1.1; 8 25.99 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (46463639..46482515)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (46010580..46029478)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr8:47020100-47020401 Neighboring gene coiled-coil domain containing 110 Neighboring gene cilia and flagella associated protein 96 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:47060555-47060664 Neighboring gene STARR-positive B cell enhancer ABC_E10496 Neighboring gene UFM1-specific peptidase 2 Neighboring gene ankyrin repeat domain 37 Neighboring gene sorting nexin 25 Neighboring gene STARR-seq mESC enhancer starr_21377 Neighboring gene STARR-positive B cell enhancer ABC_E10497 Neighboring gene predicted gene 15634 Neighboring gene cilia and flagella associated protein 97

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. Petersen HH, et al. J Cell Sci, 2003 Feb 1. PMID 12508107
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LRP2-binding protein
    Names
    megalin-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026278.3 → NP_080554.1  LRP2-binding protein

      See identical proteins and their annotated locations for NP_080554.1

      Status: VALIDATED

      Source sequence(s)
      AC114558, BB075157, BC051150
      Consensus CDS
      CCDS22286.1
      UniProtKB/Swiss-Prot
      Q3UV46, Q8CF18, Q8K0N7, Q9D4C6
      UniProtKB/TrEMBL
      G5E8E5
      Related
      ENSMUSP00000106010.3, ENSMUST00000110381.9
      Conserved Domains (3) summary
      smart00671
      Location:207 → 241
      SEL1; Sel1-like repeats
      COG0790
      Location:58 → 254
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:108 → 144
      SLR; SLR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      46463639..46482515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509483.1 → XP_006509546.1  LRP2-binding protein isoform X1

      Conserved Domains (3) summary
      smart00671
      Location:181 → 215
      SEL1; Sel1-like repeats
      COG0790
      Location:18 → 139
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:36 → 69
      SLR; SLR repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D4C6.1 GenPept UniProtKB/Swiss-Prot:Q9D4C6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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