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    Shroom1 shroom family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 71774, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Shroom1provided by MGI
    Official Full Name
    shroom family member 1provided by MGI
    Primary source
    MGI:MGI:1919024
    See related
    Ensembl:ENSMUSG00000018387 AllianceGenome:MGI:1919024
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Apx; Shrm1
    Summary
    Enables actin filament binding activity and myosin II binding activity. Involved in actin filament bundle assembly and cell morphogenesis. Predicted to be located in cytoplasm and microtubule. Predicted to be active in several cellular components, including adherens junction; apical junction complex; and apical plasma membrane. Is expressed in several structures, including alimentary system; heart; integumental system; nervous system; and sensory organ. Orthologous to human SHROOM1 (shroom family member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver adult (RPKM 13.1), placenta adult (RPKM 5.8) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Shroom1 in Genome Data Viewer
    Location:
    11 B1.3; 11 31.95 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (53347904..53358593)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (53457093..53467766)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E76 Neighboring gene growth differentiation factor 9 Neighboring gene predicted gene 10447 Neighboring gene sosondowah ankyrin repeat domain family member A Neighboring gene predicted gene 9945 Neighboring gene predicted gene, 19835

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The shroom family proteins play broad roles in the morphogenesis of thickened epithelial sheets. Lee C, et al. Dev Dyn, 2009 Jun. PMID 19384856, Free PMC Article
    2. Shroom expression is attenuated in pulmonary arterial hypertension. Sevilla-Pérez J, et al. Eur Respir J, 2008 Oct. PMID 18550613
    3. Suppression of SHROOM1 Improves In Vitro and In Vivo Gene Integration by Promoting Homology-Directed Repair. Zhao Z, et al. Int J Mol Sci, 2020 Aug 13. PMID 32823670, Free PMC Article
    4. Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction. Mohan S, et al. Mol Biol Cell, 2012 Jun. PMID 22493320, Free PMC Article
    5. Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins. Dietz ML, et al. J Biol Chem, 2006 Jul 21. PMID 16684770

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Suppression of SHROOM1 Improves In Vitro and In Vivo Gene Integration by Promoting Homology-Directed Repair.
      Title: Suppression of SHROOM1 Improves In Vitro and In Vivo Gene Integration by Promoting Homology-Directed Repair.
    2. The structure of Shrm domain 2 (SD2), which mediates the interaction with Rock and is required for Shrm function, is reported.
      Title: Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction.
    3. Shroom localises exclusively to pulmonary smooth muscle cells and is attenuated in pulmonary arterial hypertension
      Title: Shroom expression is attenuated in pulmonary arterial hypertension.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 1300007L22Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables myosin II binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in apical junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein Shroom1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290789.1 → NP_001277718.1  protein Shroom1 isoform 2

      See identical proteins and their annotated locations for NP_001277718.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the central coding region but maintains reading frame, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AK035462, AK134332, AL596095
      Consensus CDS
      CCDS70182.1
      UniProtKB/TrEMBL
      D3Z3D5
      Related
      ENSMUSP00000018531.6, ENSMUST00000018531.12
      Conserved Domains (2) summary
      pfam08687
      Location:456 → 731
      ASD2; Apx/Shroom domain ASD2
      pfam08688
      Location:140 → 239
      ASD1; Apx/Shroom domain ASD1

    2. NM_027917.3 → NP_082193.2  protein Shroom1 isoform 1

      See identical proteins and their annotated locations for NP_082193.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK035462, AK134332, AL596095
      Consensus CDS
      CCDS24680.2
      UniProtKB/Swiss-Prot
      B1AQY5, B1AQY6, Q5SX79, Q5SX83, Q99JP8
      UniProtKB/TrEMBL
      D3Z3D5
      Related
      ENSMUSP00000104641.3, ENSMUST00000109013.9
      Conserved Domains (2) summary
      pfam08687
      Location:519 → 794
      ASD2; Apx/Shroom domain ASD2
      pfam08688
      Location:140 → 239
      ASD1; Apx/Shroom domain ASD1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      53347904..53358593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534259.5 → XP_006534322.1  protein Shroom1 isoform X1

      UniProtKB/TrEMBL
      D3Z3D5
      Related
      ENSMUSP00000090802.5, ENSMUST00000093114.5
      Conserved Domains (2) summary
      pfam08687
      Location:519 → 772
      ASD2; Apx/Shroom domain ASD2
      pfam08688
      Location:140 → 244
      ASD1; Apx/Shroom domain ASD1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SX79.2 GenPept UniProtKB/Swiss-Prot:Q5SX79

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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