MYO1C myosin IC [Homo sapiens (human)] - Gene

Summary

Official Symbol: MYO1Cprovided by HGNC
Official Full Name: myosin ICprovided by HGNC
Primary source: HGNC:HGNC:7597
See related: Ensembl:ENSG00000197879 MIM:606538; AllianceGenome:HGNC:7597
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NMI; MMIb; myr2; MyoIC; MMI-beta
Summary: This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008]
Annotation information: Note: MYO1C (Gene ID: 4641) and MYO1E (Gene ID: 4643) share the MYO1C symbol/alias in common. MYO1C is a widely used alternative name for myosin IE (MYO1E), which can be confused with the official symbol for myosin IC (MYO1C). [06 Feb 2019]
Expression: Ubiquitous expression in fat (RPKM 109.9), lung (RPKM 53.1) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17p13.3

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (1464186..1492686, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (1352909..1381443, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (1367480..1395980, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RAB31 in glioma-derived endothelial cells promotes glioma cell invasion via extracellular vesicle-mediated enrichment of MYO1C.
Title: RAB31 in glioma-derived endothelial cells promotes glioma cell invasion via extracellular vesicle-mediated enrichment of MYO1C.
Elevation of truncated (48 kDa) form of unconventional myosin 1C in blood serum correlates with severe Covid-19.
Title: Elevation of truncated (48 kDa) form of unconventional myosin 1C in blood serum correlates with severe Covid-19.
m[6]A-modified circRNA MYO1C participates in the tumor immune surveillance of pancreatic ductal adenocarcinoma through m[6]A/PD-L1 manner.
Title: m(6)A-modified circRNA MYO1C participates in the tumor immune surveillance of pancreatic ductal adenocarcinoma through m(6)A/PD-L1 manner.
SH3BGRL3 binds to myosin 1c in a calcium dependent manner and modulates migration in the MDA-MB-231 cell line.
Title: SH3BGRL3 binds to myosin 1c in a calcium dependent manner and modulates migration in the MDA-MB-231 cell line.
Myosin 1C isoform A is a novel candidate diagnostic marker for prostate cancer.
Title: Myosin 1C isoform A is a novel candidate diagnostic marker for prostate cancer.
Isolation and identification in human blood serum of the proteins possessing the ability to bind with 48 kDa form of unconventional myosin 1c and their possible diagnostic and prognostic value.
Title: Isolation and identification in human blood serum of the proteins possessing the ability to bind with 48 kDa form of unconventional myosin 1c and their possible diagnostic and prognostic value.
MYO1C stabilizes actin at the Golgi complex, facilitating the arrival of incoming transport carriers at the Golgi.
Title: MYO1C stabilizes actin and facilitates the arrival of transport carriers at the Golgi complex.
E2 and NM1 associate via their N-terminal domains and this interaction is ATP dependent.
Title: Nuclear myosin 1 associates with papillomavirus E2 regulatory protein and influences viral replication.
The results establish a mechanistic connection between the calcium regulation of the motor function of myosin IC in the cytoplasm and the induction of its import into the nucleus.
Title: Calcium-regulated import of myosin IC into the nucleus.
NTR(35), which harbors the R21G mutation, was unable to confer MYO1C(35)-like kinetic behavior. Thus, the NTRs affect the specific nucleotide-binding properties of MYO1C isoforms, adding to their kinetic diversity. We propose that this level of fine-tuning within MYO1C broadens its adaptability within cells.
Title: N-terminal splicing extensions of the human MYO1C gene fine-tune the kinetics of the three full-length myosin IC isoforms.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH70953 (e-PCR)
- UniSTS:38712

A004Q21 (e-PCR)
- UniSTS:4222

D1S3693 (e-PCR)
- UniSTS:474271

D17S1510E (e-PCR)
- UniSTS:151715

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to type II interferon	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein targeting to membrane	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of bicellular tight junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle transport along actin filament	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in basal plasma membrane	IDA Inferred from Direct Assay more info
located_in brush border	IEA Inferred from Electronic Annotation more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
part_of filamentous actin	IDA Inferred from Direct Assay more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info
located_in membrane	HDA more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus	IDA Inferred from Direct Assay more info
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in phagocytic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
located_in stereocilium membrane	IEA Inferred from Electronic Annotation more info
NOT located_in stress fiber	IDA Inferred from Direct Assay more info
part_of unconventional myosin complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: unconventional myosin-Ic

Names: myosin-I beta; myosin-Ic; nuclear myosin I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047063.1 RefSeqGene

Range

5022..33522

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001080779.2 → NP_001074248.1 unconventional myosin-Ic isoform a

See identical proteins and their annotated locations for NP_001074248.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AI220881, BC068013, CA422782, DB241937

Consensus CDS

CCDS42226.1

UniProtKB/Swiss-Prot

O00159, Q4LE56, Q6NVJ7, Q86Y95

UniProtKB/TrEMBL

B7Z3E5

Related

ENSP00000496954.1, ENST00000648651.1

Conserved Domains (4) summary

smart00015
Location:756 → 776

IQ; Calmodulin-binding motif

smart00242
Location:43 → 731

MYSc; Myosin. Large ATPases

cd01378
Location:62 → 718

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:874 → 1041

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
NM_001080950.2 → NP_001074419.1 unconventional myosin-Ic isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' CDS, compared to variant 1. The resulting isoform (b) has a shorter and unique N-terminus when compared to isoform a. This isoform is also known as nuclear myosin I.

Source sequence(s)

AC100748, AI220881, BC068013, BP284965, CA422782, CN313279, DB241937

Consensus CDS

CCDS45562.1

UniProtKB/TrEMBL

B7Z3E5

Related

ENSP00000496799.1, ENST00000648446.1

Conserved Domains (4) summary

smart00015
Location:737 → 757

IQ; Calmodulin-binding motif

smart00242
Location:24 → 712

MYSc; Myosin. Large ATPases

cd01378
Location:43 → 699

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:855 → 1022

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
NM_001363855.1 → NP_001350784.1 unconventional myosin-Ic isoform d

Status: REVIEWED

Source sequence(s)

AC100748, AK295761, KF495829

Consensus CDS

CCDS86556.1

UniProtKB/TrEMBL

B7Z3E5, F5H6E2

Related

ENSP00000437685.2, ENST00000545534.6

Conserved Domains (3) summary

smart00015
Location:732 → 752

IQ; Calmodulin-binding motif

cd01378
Location:38 → 694

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:850 → 1016

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
NM_033375.5 → NP_203693.3 unconventional myosin-Ic isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (c) has a shorter N terminus when compared to isoform a.

Source sequence(s)

AC100748, AI220881, BC068013, BP255642, CA422782, DB241937

Consensus CDS

CCDS11003.1

UniProtKB/TrEMBL

B7Z3E5

Related

ENSP00000354283.2, ENST00000361007.7

Conserved Domains (3) summary

smart00015
Location:721 → 741

IQ; Calmodulin-binding motif

cd01378
Location:27 → 683

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:839 → 1005

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

1464186..1492686 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047436137.1 → XP_047292093.1 unconventional myosin-Ic isoform X1
XM_047436134.1 → XP_047292090.1 unconventional myosin-Ic isoform X1

Related

ENSP00000459271.3, ENST00000570984.7
XM_047436133.1 → XP_047292089.1 unconventional myosin-Ic isoform X1
XM_024450768.2 → XP_024306536.1 unconventional myosin-Ic isoform X1

UniProtKB/TrEMBL

B7Z3E5

Related

ENSP00000493973.1, ENST00000646049.1

Conserved Domains (3) summary

smart00015
Location:721 → 741

IQ; Calmodulin-binding motif

cd01378
Location:27 → 683

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:839 → 1005

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
XM_024450769.2 → XP_024306537.1 unconventional myosin-Ic isoform X1

UniProtKB/TrEMBL

B7Z3E5

Related

ENSP00000459174.1, ENST00000575158.5

Conserved Domains (3) summary

smart00015
Location:721 → 741

IQ; Calmodulin-binding motif

cd01378
Location:27 → 683

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:839 → 1005

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
XM_047436136.1 → XP_047292092.1 unconventional myosin-Ic isoform X1