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    Wwc2 WW, C2 and coiled-coil domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 52357, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Wwc2provided by MGI
    Official Full Name
    WW, C2 and coiled-coil domain containing 2provided by MGI
    Primary source
    MGI:MGI:1261872
    See related
    Ensembl:ENSMUSG00000031563 AllianceGenome:MGI:1261872
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D8Ertd594e; 5330431C14Rik
    Summary
    Predicted to enable kinase binding activity and molecular adaptor activity. Predicted to be involved in several processes, including negative regulation of hippo signaling; negative regulation of organ growth; and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in telencephalon. Orthologous to human WWC2 (WW and C2 domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 18.6), testis adult (RPKM 13.9) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 B1.1; 8 26.91 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (48279117..48443579, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (47826082..47990544, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene claudin 24 Neighboring gene claudin 22 Neighboring gene predicted gene, 39173 Neighboring gene STARR-seq mESC enhancer starr_21422 Neighboring gene STARR-seq mESC enhancer starr_21423 Neighboring gene predicted gene, 31984 Neighboring gene predicted gene, 32052 Neighboring gene STARR-seq mESC enhancer starr_21426 Neighboring gene STARR-seq mESC enhancer starr_21427 Neighboring gene STARR-seq mESC enhancer starr_21428 Neighboring gene dCMP deaminase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. WWC2 expression in the testis: Implications for spermatogenesis and male fertility. Höffken V, et al. FASEB J, 2023 May. PMID 37086090
    2. Lack of WWC2 Protein Leads to Aberrant Angiogenesis in Postnatal Mice. Brücher VC, et al. Int J Mol Sci, 2021 May 18. PMID 34070186, Free PMC Article
    3. WW and C2 domain-containing proteins regulate hepatic cell differentiation and tumorigenesis through the hippo signaling pathway. Hermann A, et al. Hepatology, 2018 Apr. PMID 29116649
    4. WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy. Qi S, et al. Mol Cell, 2022 May 19. PMID 35429439
    5. The Hippo pathway component Wwc2 is a key regulator of embryonic development and angiogenesis in mice. Hermann A, et al. Cell Death Dis, 2021 Jan 22. PMID 33483469, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WWC2 expression in the testis: Implications for spermatogenesis and male fertility.
      Title: WWC2 expression in the testis: Implications for spermatogenesis and male fertility.
    2. The Hippo pathway component Wwc2 is a key regulator of embryonic development and angiogenesis in mice.
      Title: The Hippo pathway component Wwc2 is a key regulator of embryonic development and angiogenesis in mice.
    3. Lack of WWC2 Protein Leads to Aberrant Angiogenesis in Postnatal Mice.
      Title: Lack of WWC2 Protein Leads to Aberrant Angiogenesis in Postnatal Mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of organ growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of organ growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein WWC2
    Names
    WW domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133791.5 → NP_598552.2  protein WWC2

      See identical proteins and their annotated locations for NP_598552.2

      Status: VALIDATED

      Source sequence(s)
      AC110509, AC161202
      Consensus CDS
      CCDS22301.1
      UniProtKB/Swiss-Prot
      Q3UGG4, Q3UH10, Q6NXJ0, Q7TMY1, Q8CE61, Q9JJ63
      Related
      ENSMUSP00000056121.8, ENSMUST00000057561.9
      Conserved Domains (3) summary
      cd08680
      Location:699 → 822
      C2_Kibra; C2 domain found in Human protein Kibra
      pfam00397
      Location:12 → 41
      WW; WW domain
      cl01720
      Location:1088 → 1146
      Phage_Nu1; Phage DNA packaging protein Nu1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      48279117..48443579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154163.1 → XP_036010056.1  protein WWC2 isoform X1

      Conserved Domains (4) summary
      cd08680
      Location:676 → 799
      C2_Kibra; C2 domain found in Human protein Kibra
      COG1196
      Location:75 → 392
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd06503
      Location:1051 → 1138
      ATP-synt_Fo_b; F-type ATP synthase, membrane subunit b
      pfam00397
      Location:36 → 65
      WW; WW domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NXJ0.1 GenPept UniProtKB/Swiss-Prot:Q6NXJ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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