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    Ric3 RIC3 acetylcholine receptor chaperone [ Mus musculus (house mouse) ]

    Gene ID: 320360, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Ric3provided by MGI
    Official Full Name
    RIC3 acetylcholine receptor chaperoneprovided by MGI
    Primary source
    MGI:MGI:2443887
    See related
    Ensembl:ENSMUSG00000048330 AllianceGenome:MGI:2443887
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E130307J04Rik
    Summary
    Enables protein folding chaperone. Acts upstream of or within cellular protein-containing complex assembly. Located in endoplasmic reticulum. Is integral component of membrane. Orthologous to human RIC3 (RIC3 acetylcholine receptor chaperone). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 12.0), cortex adult (RPKM 7.6) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 E3; 7 57.21 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (108633475..108682538, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (109034268..109083432, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39067 Neighboring gene predicted gene, 32309 Neighboring gene TUB bipartite transcription factor Neighboring gene predicted gene, 25450 Neighboring gene STARR-seq mESC enhancer starr_19793 Neighboring gene predicted gene 44781 Neighboring gene LIM domain only 1 Neighboring gene STARR-seq mESC enhancer starr_19794 Neighboring gene predicted gene, 32563

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RIC3, the cholinergic anti-inflammatory pathway, and neuroinflammation. Ben-David Y, et al. Int Immunopharmacol, 2020 Jun. PMID 32179243
    2. RIC-3 expression and splicing regulate nAChR functional expression. Ben-David Y, et al. Mol Brain, 2016 Apr 29. PMID 27129882, Free PMC Article
    3. Ric-3 promotes alpha7 nicotinic receptor assembly and trafficking through the ER subcompartment of dendrites. Alexander JK, et al. J Neurosci, 2010 Jul 28. PMID 20668195, Free PMC Article
    4. Mouse RIC-3, an endoplasmic reticulum chaperone, promotes assembly of the alpha7 acetylcholine receptor through a cytoplasmic coiled-coil domain. Wang Y, et al. J Neurosci, 2009 Oct 7. PMID 19812337, Free PMC Article
    5. Why Does Knocking Out NACHO, But Not RIC3, Completely Block Expression of α7 Nicotinic Receptors in Mouse Brain? Deshpande A, et al. Biomolecules, 2020 Mar 19. PMID 32204458, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Why Does Knocking Out NACHO, But Not RIC3, Completely Block Expression of alpha7 Nicotinic Receptors in Mouse Brain?
      Title: Why Does Knocking Out NACHO, But Not RIC3, Completely Block Expression of α7 Nicotinic Receptors in Mouse Brain?
    2. RIC3, the cholinergic anti-inflammatory pathway, and neuroinflammation.
      Title: RIC3, the cholinergic anti-inflammatory pathway, and neuroinflammation.
    3. Regulation of expression level and splicing of RIC-3 in brain and in immune cells following inflammation enables regulation of nicotinic acetylcholine receptor functional expression.
      Title: RIC-3 expression and splicing regulate nAChR functional expression.
    4. In neurons, Ric-3 ER retention appears to promote transport within the dendritic ER subcompartment, thereby restricting 7 trafficking to dendrites and preventing axonal transport.
      Title: Ric-3 promotes alpha7 nicotinic receptor assembly and trafficking through the ER subcompartment of dendrites.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylcholine receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein folding chaperone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic transmission, cholinergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within synaptic transmission, cholinergic ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein RIC-3
    Names
    resistance to inhibitors of cholinesterase 3 homolog
    resistant to inhibitor of cholinesterase 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038624.1 → NP_001033713.1  protein RIC-3 isoform a precursor

      See identical proteins and their annotated locations for NP_001033713.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform a).
      Source sequence(s)
      BC059258, BY241896, BY279630
      Consensus CDS
      CCDS21733.1
      UniProtKB/Swiss-Prot
      Q6PCM7, Q8BPM6, Q8C4G2
      Related
      ENSMUSP00000056990.7, ENSMUST00000055993.13
      Conserved Domains (1) summary
      pfam15361
      Location:19 → 164
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    2. NM_001311161.1 → NP_001298090.1  protein RIC-3 isoform c precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The resulting protein (isoform c) is shorter compared to isoform a.
      Source sequence(s)
      AK138641, BC059258, BY241896
      Consensus CDS
      CCDS80778.1
      UniProtKB/TrEMBL
      D3YTZ9
      Related
      ENSMUSP00000112788.2, ENSMUST00000120876.2
      Conserved Domains (1) summary
      pfam15361
      Location:19 → 164
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    3. NM_178780.3 → NP_848895.2  protein RIC-3 isoform b precursor

      See identical proteins and their annotated locations for NP_848895.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes a 3' terminal exon that extends past a splice site used in variant 1 that leads to a frameshift. The resulting protein (isoform b) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AK149334, BY279630
      UniProtKB/Swiss-Prot
      Q8BPM6
      Conserved Domains (1) summary
      pfam15361
      Location:19 → 164
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      108633475..108682538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507942.3 → XP_006508005.1  protein RIC-3 isoform X1

      See identical proteins and their annotated locations for XP_006508005.1

      UniProtKB/Swiss-Prot
      Q8BPM6

    2. XM_006507943.5 → XP_006508006.1  protein RIC-3 isoform X1

      See identical proteins and their annotated locations for XP_006508006.1

      UniProtKB/Swiss-Prot
      Q8BPM6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BPM6.2 GenPept UniProtKB/Swiss-Prot:Q8BPM6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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