Aldh1b1 aldehyde dehydrogenase 1 family, member B1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aldh1b1provided by RGD
Official Full Name: aldehyde dehydrogenase 1 family, member B1provided by RGD
Primary source: RGD:1306737
See related: Ensembl:ENSRNOG00000011497 AllianceGenome:RGD:1306737
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in ethanol catabolic process. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Orthologous to human ALDH1B1 (aldehyde dehydrogenase 1 family member B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 343.4) and Brain (RPKM 33.8) See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 5q22

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (64859000..64864008)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (60063370..60068378)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (61382351..61387359)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:546646

Aldh1b1 (e-PCR), detects polymorphism
- UniSTS:546646

RH129900 (e-PCR)
- UniSTS:213188

GDB:280630 (e-PCR)
- UniSTS:156381

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aldehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in ethanol catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: aldehyde dehydrogenase X, mitochondrial

Names: aldehyde dehydrogenase 1B1; aldehyde dehydrogenase family 1 member B1

NP_001011975.1

EC 1.2.1.3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011975.1 → NP_001011975.1 aldehyde dehydrogenase X, mitochondrial precursor

See identical proteins and their annotated locations for NP_001011975.1

Status: PROVISIONAL

Source sequence(s)

BC081884

UniProtKB/Swiss-Prot

Q66HF8

UniProtKB/TrEMBL

A6IJA2, G3V7I5

Related

ENSRNOP00000015282.3, ENSRNOT00000015281.5

Conserved Domains (2) summary

cd07141
Location:33 → 513

ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like

PLN02466
Location:13 → 510

PLN02466; aldehyde dehydrogenase family 2 member