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    IFI44 interferon induced protein 44 [ Homo sapiens (human) ]

    Gene ID: 10561, updated on 3-Apr-2024

    Summary

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    Official Symbol
    IFI44provided by HGNC
    Official Full Name
    interferon induced protein 44provided by HGNC
    Primary source
    HGNC:HGNC:16938
    See related
    Ensembl:ENSG00000137965 MIM:610468; AllianceGenome:HGNC:16938
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p44; TLDC5; MTAP44
    Summary
    Predicted to be involved in immune response. Predicted to act upstream of or within response to bacterium. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bone marrow (RPKM 19.2), spleen (RPKM 17.3) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    1p31.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (78649789..78664078)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (78488644..78502933)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (79115474..79129763)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:78957125-78957657 Neighboring gene prostaglandin F receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1235 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1236 Neighboring gene interferon induced protein 44 like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1237 Neighboring gene ribosomal protein L23 pseudogene 3 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:79157716-79158915 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:79193777-79194278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:79194279-79194778 Neighboring gene SNW domain containing 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. IFI44 is an immune evasion biomarker for SARS-CoV-2 and Staphylococcus aureus infection in patients with RA. Zheng Q, et al. Front Immunol, 2022. PMID 36189314, Free PMC Article
    2. IFI44 suppresses HIV-1 LTR promoter activity and facilitates its latency. Power D, et al. Virology, 2015 Jul. PMID 25776761, Free PMC Article
    3. Antiproliferative activity of the human IFN-alpha-inducible protein IFI44. Hallen LC, et al. J Interferon Cytokine Res, 2007 Aug. PMID 17784819
    4. Induction of the human gene for p44, a hepatitis-C-associated microtubular aggregate protein, by interferon-alpha/beta. Kitamura A, et al. Eur J Biochem, 1994 Sep 15. PMID 7925411
    5. Interferon-Induced Protein 44 Interacts with Cellular FK506-Binding Protein 5, Negatively Regulates Host Antiviral Responses, and Supports Virus Replication. DeDiego ML, et al. mBio, 2019 Aug 27. PMID 31455651, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IFI44 is an immune evasion biomarker for SARS-CoV-2 and Staphylococcus aureus infection in patients with RA.
      Title: IFI44 is an immune evasion biomarker for SARS-CoV-2 and Staphylococcus aureus infection in patients with RA.
    2. Interferon-Induced Protein 44 and Interferon-Induced Protein 44-Like Restrict Replication of Respiratory Syncytial Virus.
      Title: Interferon-Induced Protein 44 and Interferon-Induced Protein 44-Like Restrict Replication of Respiratory Syncytial Virus.
    3. The data indicate that binding of IFI44 to FKBP5 decreased the phosphorylation of IRF-3 and IkappaBalpha mediated by IKKepsilon and IKKbeta, respectively, providing a likely explanation for the function of IFI44 in negatively modulating IFN responses.
      Title: Interferon-Induced Protein 44 Interacts with Cellular FK506-Binding Protein 5, Negatively Regulates Host Antiviral Responses, and Supports Virus Replication.
    4. IFI44 localizes to nuclei and suppresses HIV-1 LTR promoter.
      Title: IFI44 suppresses HIV-1 LTR promoter activity and facilitates its latency.
    5. The restriction of Bunyamwera virus replication mediated by interferon is an accumulated effect of at least three interferon-stimulated genes viperin, MTAP44 and PKR.
      Title: Viperin, MTAP44, and protein kinase R contribute to the interferon-induced inhibition of Bunyamwera Orthobunyavirus replication.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: New genetic associations detected in a host response study to hepatitis B vaccine.
    7. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Genetic predisposition of responsiveness to therapy for chronic hepatitis C.
    8. Binds and depletes intracellular GTP, abolishing extracellular signal-regulated kinase (ERK) signaling and resulting finally in cell cycle arrest.
      Title: Antiproliferative activity of the human IFN-alpha-inducible protein IFI44.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of interferon-induced protein 44 (IFI44) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 and the viral protein Tat modulate the expression of interferon-inducible protein 44 (IFI44) in immature dendritic cells and monocyte-derived macrophages PubMed
    tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including MTAp44, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to virus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    interferon-induced protein 44
    Names
    TBC/LysM-associated domain containing 5
    interferon-induced, hepatitis C-associated microtubular aggregate protein (44kD)
    microtubule-associated protein 44

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006417.5 → NP_006408.3  interferon-induced protein 44

      See identical proteins and their annotated locations for NP_006408.3

      Status: VALIDATED

      Source sequence(s)
      BC022870, CA426666, DC300799, DN994910
      Consensus CDS
      CCDS688.1
      UniProtKB/Swiss-Prot
      B7ZAG3, D3DQ80, Q14496, Q8TCB0
      UniProtKB/TrEMBL
      B7ZB11
      Related
      ENSP00000359783.4, ENST00000370747.9
      Conserved Domains (1) summary
      cl02144
      Location:28 → 87
      TLD; TLD

    RNA

    1. NR_135640.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI061108, AK316476, AL589497, BC022870
      Related
      ENST00000472152.5

    2. NR_135641.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI061108, AK316476, AL589497, BC022870

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      78649789..78664078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540516.4 → XP_011538818.1  interferon-induced protein 44 isoform X1

      UniProtKB/TrEMBL
      B7ZB11
      Conserved Domains (1) summary
      cl02144
      Location:28 → 70
      TLD; TLD

    2. XM_047433671.1 → XP_047289627.1  interferon-induced protein 44 isoform X5

    3. XM_047433700.1 → XP_047289656.1  interferon-induced protein 44 isoform X6

    4. XM_047433600.1 → XP_047289556.1  interferon-induced protein 44 isoform X2

    5. XM_047433620.1 → XP_047289576.1  interferon-induced protein 44 isoform X3

    6. XM_047433638.1 → XP_047289594.1  interferon-induced protein 44 isoform X3

    7. XM_017000083.3 → XP_016855572.1  interferon-induced protein 44 isoform X4

      UniProtKB/TrEMBL
      B7ZB11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      78488644..78502933
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333877.1 → XP_054189852.1  interferon-induced protein 44 isoform X1

    2. XM_054333882.1 → XP_054189857.1  interferon-induced protein 44 isoform X5

    3. XM_054333883.1 → XP_054189858.1  interferon-induced protein 44 isoform X6

    4. XM_054333878.1 → XP_054189853.1  interferon-induced protein 44 isoform X2

    5. XM_054333879.1 → XP_054189854.1  interferon-induced protein 44 isoform X3

    6. XM_054333880.1 → XP_054189855.1  interferon-induced protein 44 isoform X3

    7. XM_054333881.1 → XP_054189856.1  interferon-induced protein 44 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TCB0.2 GenPept UniProtKB/Swiss-Prot:Q8TCB0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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