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    FCRL2 Fc receptor like 2 [ Homo sapiens (human) ]

    Gene ID: 79368, updated on 11-Apr-2024

    Summary

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    Official Symbol
    FCRL2provided by HGNC
    Official Full Name
    Fc receptor like 2provided by HGNC
    Primary source
    HGNC:HGNC:14875
    See related
    Ensembl:ENSG00000132704 MIM:606509; AllianceGenome:HGNC:14875
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FCRH2; IFGP4; IRTA4; SPAP1; CD307b; SPAP1A; SPAP1B; SPAP1C
    Summary
    This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Apr 2009]
    Expression
    Biased expression in lymph node (RPKM 14.2), spleen (RPKM 13.1) and 7 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1q23.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (157745733..157777132, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (156882776..156914199, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (157715523..157746922, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SON pseudogene 1 Neighboring gene voltage dependent anion channel 1 pseudogene 9 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:157739405-157740604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1895 Neighboring gene Fc receptor like 1 Neighboring gene CD5 molecule like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Fc receptor-like 2 (FCRL2) is a novel marker of low-risk CLL and refines prognostication based on IGHV mutation status. Shea LK, et al. Blood Cancer J, 2019 May 15. PMID 31092813, Free PMC Article
    2. FCRL2 mRNA expression is inversely associated with clinical progression in chronic lymphocytic leukemia. Nückel H, et al. Eur J Haematol, 2009 Dec 1. PMID 19682311
    3. FCRL2 expression predicts IGHV mutation status and clinical progression in chronic lymphocytic leukemia. Li FJ, et al. Blood, 2008 Jul 1. PMID 18314442, Free PMC Article
    4. Investigation of the human FCRL1, 2, and 4 gene expressions in patients with rheumatoid arthritis. Khanzadeh A, et al. Rheumatol Int, 2016 Aug. PMID 27193470
    5. FcR-like 2 Inhibition of B cell receptor-mediated activation of B cells. Jackson TA, et al. J Immunol, 2010 Dec 15. PMID 21068405, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression profile of Fc receptor-like molecules in patients with IgA nephropathy.
      Title: Expression profile of Fc receptor-like molecules in patients with IgA nephropathy.
    2. we have shown that FCRL2 is a powerful predictor of both TFT and OS in CLL and have validated the prognostic significance of FCRL2 in a new cohort of patients.
      Title: Fc receptor-like 2 (FCRL2) is a novel marker of low-risk CLL and refines prognostication based on IGHV mutation status.
    3. decreased FCRL4 expression and association of FCRL2 expression with inflammatory markers and disease activity suggested the contribution of these molecules to rheumatoid arthritis inflammatory processes.
      Title: Investigation of the human FCRL1, 2, and 4 gene expressions in patients with rheumatoid arthritis.
    4. FCRL2 overexpression in B cells from Hashimoto and Graves disease patients compared to normal subjects.
      Title: Expression Profile of Human Fc Receptor-Like 1, 2, and 4 Molecules in Peripheral Blood Mononuclear Cells of Patients with Hashimoto's Thyroiditis and Graves' Disease.
    5. a negative immunomodulatory function for FCRL2 in the regulation of memory B cells.
      Title: FcR-like 2 Inhibition of B cell receptor-mediated activation of B cells.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: New genetic associations detected in a host response study to hepatitis B vaccine.
    7. B-CLL patients with high FCRL2 expression had a significantly longer treatment-free survival & overall survival than those with low FCRL2.
      Title: FCRL2 mRNA expression is inversely associated with clinical progression in chronic lymphocytic leukemia.
    8. Down-regulation of FCRL2 is associated with acute lymphoblastic leukemia.
      Title: Low representation of Fc receptor-like 1-5 molecules in leukemic cells from Iranian patients with acute lymphoblastic leukemia.
    9. Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia.
      Title: Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia.
    10. FCRL2 has robust predictive value for determining IGHV gene mutation status and clinical progression and thus may further improve prognostic definition in chronic lymphocytic leukemia.
      Title: FCRL2 expression predicts IGHV mutation status and clinical progression in chronic lymphocytic leukemia.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell signaling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Fc receptor-like protein 2
    Names
    IFGP family protein 4
    SH2 domain containing phosphatase anchor protein 1
    fc receptor homolog 2
    immune receptor translocation-associated protein 4
    immunoglobulin receptor translocation-associated protein 4
    immunoglobulin superfamily Fc receptor, gp42

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159488.2 → NP_001152960.1  Fc receptor-like protein 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001152960.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks three alternate exons in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AF459633, AK301113, AK303549
      UniProtKB/TrEMBL
      B4DVJ9
      Conserved Domains (3) summary
      smart00410
      Location:216 → 288
      IG_like; Immunoglobulin like
      pfam13895
      Location:23 → 102
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:108 → 181
      Ig_3; Immunoglobulin domain

    2. NM_030764.4 → NP_110391.2  Fc receptor-like protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_110391.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF459633, AK303549, AY358130
      Consensus CDS
      CCDS1168.1
      UniProtKB/Swiss-Prot
      A0N0M5, A1L307, A6NMS0, Q6NTA1, Q96LA5, Q9BZI4, Q9BZI5, Q9BZI6
      Related
      ENSP00000355157.3, ENST00000361516.8
      Conserved Domains (3) summary
      smart00410
      Location:216 → 288
      IG_like; Immunoglobulin like
      pfam13895
      Location:23 → 102
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:108 → 181
      Ig_3; Immunoglobulin domain

    RNA

    1. NR_125358.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks four alternate internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the reading frame found in variant 1.
      Source sequence(s)
      AF459633, BC069185
      Related
      ENST00000368181.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      157745733..157777132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430275.1 → XP_047286231.1  Fc receptor-like protein 2 isoform X10

    2. XM_017002319.2 → XP_016857808.1  Fc receptor-like protein 2 isoform X7

    3. XM_047430273.1 → XP_047286229.1  Fc receptor-like protein 2 isoform X9

    4. XM_017002318.2 → XP_016857807.1  Fc receptor-like protein 2 isoform X6

      Conserved Domains (2) summary
      smart00409
      Location:216 → 288
      IG; Immunoglobulin
      cl11960
      Location:120 → 180
      Ig; Immunoglobulin domain

    5. XM_047430270.1 → XP_047286226.1  Fc receptor-like protein 2 isoform X8

    6. XM_017002317.2 → XP_016857806.1  Fc receptor-like protein 2 isoform X5

    7. XM_011509976.3 → XP_011508278.1  Fc receptor-like protein 2 isoform X4

      Conserved Domains (3) summary
      smart00410
      Location:216 → 288
      IG_like; Immunoglobulin like
      pfam13895
      Location:23 → 102
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:108 → 181
      Ig_3; Immunoglobulin domain

    8. XM_011509975.4 → XP_011508277.1  Fc receptor-like protein 2 isoform X3

      Conserved Domains (3) summary
      smart00410
      Location:216 → 288
      IG_like; Immunoglobulin like
      pfam13895
      Location:23 → 102
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:108 → 181
      Ig_3; Immunoglobulin domain

    9. XM_017002316.2 → XP_016857805.1  Fc receptor-like protein 2 isoform X1

    10. XM_011509974.4 → XP_011508276.1  Fc receptor-like protein 2 isoform X2

      See identical proteins and their annotated locations for XP_011508276.1

      Conserved Domains (3) summary
      smart00410
      Location:216 → 288
      IG_like; Immunoglobulin like
      pfam13895
      Location:23 → 102
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:108 → 181
      Ig_3; Immunoglobulin domain

    11. XM_006711535.4 → XP_006711598.1  Fc receptor-like protein 2 isoform X11

      Conserved Domains (3) summary
      smart00410
      Location:216 → 288
      IG_like; Immunoglobulin like
      pfam13895
      Location:23 → 102
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:108 → 181
      Ig_3; Immunoglobulin domain

    RNA

    1. XR_001737404.2 RNA Sequence

    2. XR_001737403.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      156882776..156914199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338703.1 → XP_054194678.1  Fc receptor-like protein 2 isoform X10

    2. XM_054338700.1 → XP_054194675.1  Fc receptor-like protein 2 isoform X7

    3. XM_054338702.1 → XP_054194677.1  Fc receptor-like protein 2 isoform X9

    4. XM_054338699.1 → XP_054194674.1  Fc receptor-like protein 2 isoform X6

    5. XM_054338701.1 → XP_054194676.1  Fc receptor-like protein 2 isoform X8

    6. XM_054338698.1 → XP_054194673.1  Fc receptor-like protein 2 isoform X5

    7. XM_054338697.1 → XP_054194672.1  Fc receptor-like protein 2 isoform X4

    8. XM_054338696.1 → XP_054194671.1  Fc receptor-like protein 2 isoform X3

    9. XM_054338694.1 → XP_054194669.1  Fc receptor-like protein 2 isoform X1

    10. XM_054338695.1 → XP_054194670.1  Fc receptor-like protein 2 isoform X2

    11. XM_054338704.1 → XP_054194679.1  Fc receptor-like protein 2 isoform X11

    RNA

    1. XR_008486161.1 RNA Sequence

    2. XR_008486160.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_138738.3: Suppressed sequence

      Description
      NM_138738.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.

    2. NM_138739.1: Suppressed sequence

      Description
      NM_138739.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96LA5.1 GenPept UniProtKB/Swiss-Prot:Q96LA5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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