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    Ltbp3 latent transforming growth factor beta binding protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83838, updated on 2-May-2024

    Summary

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    Official Symbol
    Ltbp3provided by RGD
    Official Full Name
    latent transforming growth factor beta binding protein 3provided by RGD
    Primary source
    RGD:62057
    See related
    Ensembl:ENSRNOG00000020813 AllianceGenome:RGD:62057
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transforming growth factor beta binding activity. Predicted to be involved in several processes, including elastic fiber assembly; positive regulation of mesenchymal stem cell differentiation; and positive regulation of mesenchymal stem cell proliferation. Predicted to act upstream of or within several processes, including negative regulation of bone mineralization; negative regulation of chondrocyte differentiation; and positive regulation of bone resorption. Predicted to be located in collagen-containing extracellular matrix and extracellular region. Human ortholog(s) of this gene implicated in brachyolmia-amelogenesis imperfecta syndrome and geleophysic dysplasia 3. Orthologous to human LTBP3 (latent transforming growth factor beta binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 90.3), Uterus (RPKM 74.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ltbp3 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212458362..212475302)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203029412..203045975)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221099155..221116096)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene EH domain binding protein 1-like 1 Neighboring gene family with sequence similarity 89, member B Neighboring gene zinc ribbon domain containing 2 Neighboring gene SCY1 like pseudokinase 1 Neighboring gene uncharacterized LOC120097382 Neighboring gene uncharacterized LOC120097381 Neighboring gene FERM domain containing 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Lung alveolar septation defects in Ltbp-3-null mice. Colarossi C, et al. Am J Pathol, 2005 Aug. PMID 16049328, Free PMC Article
    2. Osteopetrosis-like phenotype in latent TGF-beta binding protein 3 deficient mice. Dabovic B, et al. Bone, 2005 Jul. PMID 15878314
    3. Bone abnormalities in latent TGF-[beta] binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-[beta] bioavailability. Dabovic B, et al. J Cell Biol, 2002 Jan 21. PMID 11790802, Free PMC Article
    4. Isoforms and splice variant of transforming growth factor beta-binding protein in rat hepatic stellate cells. Gong W, et al. Gastroenterology, 1998 Feb. PMID 9453497
    5. Isolation of a novel latent transforming growth factor-beta binding protein gene (LTBP-3). Yin W, et al. J Biol Chem, 1995 Apr 28. PMID 7730318

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.
      Title: Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transforming growth factor beta binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within bone morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within bone remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lung saccule development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mesenchymal stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mesenchymal stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    latent-transforming growth factor beta-binding protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191561.1 → NP_001178490.1  latent-transforming growth factor beta-binding protein 3 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      F1LRT0
      Conserved Domains (4) summary
      smart00179
      Location:741 → 781
      EGF_CA; Calcium-binding EGF-like domain
      PHA03247
      Location:484 → 574
      PHA03247; large tegument protein UL36; Provisional
      cd00054
      Location:657 → 692
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00683
      Location:412 → 453
      TB; TB domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      212458362..212475302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092642.2 → XP_038948570.1  latent-transforming growth factor beta-binding protein 3 isoform X1

      Conserved Domains (4) summary
      smart00179
      Location:741 → 781
      EGF_CA; Calcium-binding EGF-like domain
      PHA03247
      Location:484 → 574
      PHA03247; large tegument protein UL36; Provisional
      cd00054
      Location:657 → 692
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00683
      Location:412 → 453
      TB; TB domain

    2. XM_063275645.1 → XP_063131715.1  latent-transforming growth factor beta-binding protein 3 isoform X2

    3. XM_039092644.2 → XP_038948572.1  latent-transforming growth factor beta-binding protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AVC5
      Related
      ENSRNOP00000096627.1
      Conserved Domains (4) summary
      smart00179
      Location:741 → 781
      EGF_CA; Calcium-binding EGF-like domain
      PHA03247
      Location:484 → 574
      PHA03247; large tegument protein UL36; Provisional
      cd00054
      Location:657 → 692
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00683
      Location:412 → 453
      TB; TB domain

    4. XM_006230906.5 → XP_006230968.1  latent-transforming growth factor beta-binding protein 3 isoform X5

      Conserved Domains (3) summary
      smart00179
      Location:741 → 781
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:657 → 692
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00683
      Location:412 → 447
      TB; TB domain

    5. XM_039092648.2 → XP_038948576.1  latent-transforming growth factor beta-binding protein 3 isoform X7

      UniProtKB/TrEMBL
      F1LRT0
      Related
      ENSRNOP00000028262.5
      Conserved Domains (4) summary
      smart00179
      Location:741 → 781
      EGF_CA; Calcium-binding EGF-like domain
      PHA03247
      Location:484 → 574
      PHA03247; large tegument protein UL36; Provisional
      cd00054
      Location:657 → 692
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00683
      Location:412 → 453
      TB; TB domain

    6. XM_063275647.1 → XP_063131717.1  latent-transforming growth factor beta-binding protein 3 isoform X3

    7. XM_063275653.1 → XP_063131723.1  latent-transforming growth factor beta-binding protein 3 isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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