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    Fyb1 FYN binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499537, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fyb1provided by RGD
    Official Full Name
    FYN binding protein 1provided by RGD
    Primary source
    RGD:1563421
    See related
    Ensembl:ENSRNOG00000013886 AllianceGenome:RGD:1563421
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fyb; ADAP; SLAP-130; p120/p130; RGD1563421
    Summary
    Predicted to enable lipid binding activity. Predicted to be involved in T cell receptor signaling pathway; integrin-mediated signaling pathway; and protein localization to plasma membrane. Predicted to be located in several cellular components, including actin cytoskeleton; cell junction; and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human FYB1 (FYN binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 139.4), Spleen (RPKM 114.5) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q16
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (57360084..57508609)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (55621585..55781206)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (55834904..55983805)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene DAB adaptor protein 2 Neighboring gene uncharacterized LOC120100732 Neighboring gene uncharacterized LOC120100733 Neighboring gene complement C9 Neighboring gene RPTOR independent companion of MTOR, complex 2 Neighboring gene oncostatin M receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential requirement for adapter proteins Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and adhesion- and degranulation-promoting adapter protein in FcepsilonRI signaling and mast cell function. Wu JN, et al. J Immunol, 2004 Jun 1. PMID 15153494
    2. Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells. Fujii Y, et al. FEBS Lett, 2003 Apr 10. PMID 12681493
    3. RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation. Ménasché G, et al. Mol Cell Biol, 2007 Jun. PMID 17403904, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT acts_upstream_of_or_within mast cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    FYN-binding protein 1
    Names
    FYB-120/130
    FYN binding protein (FYB-120/130)
    FYN-T-binding protein
    FYN-binding protein
    SLP-76-associated phosphoprotein
    adhesion and degranulation promoting adaptor protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109176.1 → NP_001102646.1  FYN-binding protein 1

      See identical proteins and their annotated locations for NP_001102646.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474048
      UniProtKB/TrEMBL
      A6KGF4, A6KGF5
      Conserved Domains (3) summary
      PHA03247
      Location:40 → 416
      PHA03247; large tegument protein UL36; Provisional
      pfam14603
      Location:732 → 820
      hSH3; Helically-extended SH3 domain
      cl17036
      Location:489 → 592
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      57360084..57508609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232019.5 → XP_006232081.1  FYN-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3ZIE4
      UniProtKB/TrEMBL
      A6KGF5
      Related
      ENSRNOP00000018634.6
      Conserved Domains (3) summary
      PHA03247
      Location:50 → 426
      PHA03247; large tegument protein UL36; Provisional
      pfam14603
      Location:743 → 830
      hSH3; Helically-extended SH3 domain
      cl17036
      Location:500 → 602
      SH3; Src Homology 3 domain superfamily

    2. XM_039102839.2 → XP_038958767.1  FYN-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6G9A9, A6KGF5
      Related
      ENSRNOP00000083646.1
      Conserved Domains (3) summary
      PHA03247
      Location:50 → 426
      PHA03247; large tegument protein UL36; Provisional
      pfam14603
      Location:696 → 784
      hSH3; Helically-extended SH3 domain
      cl17036
      Location:499 → 561
      SH3; Src Homology 3 domain superfamily

    3. XM_008760785.4 → XP_008759007.2  FYN-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A6KGF5
      Conserved Domains (3) summary
      PHA03247
      Location:50 → 426
      PHA03247; large tegument protein UL36; Provisional
      pfam14603
      Location:738 → 826
      hSH3; Helically-extended SH3 domain
      cl17036
      Location:495 → 598
      SH3; Src Homology 3 domain superfamily

    4. XM_063282350.1 → XP_063138420.1  FYN-binding protein 1 isoform X5

    5. XM_039102837.1 → XP_038958765.1  FYN-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A6KGF4, A6KGF5
      Conserved Domains (3) summary
      PHA03247
      Location:40 → 416
      PHA03247; large tegument protein UL36; Provisional
      pfam14603
      Location:732 → 820
      hSH3; Helically-extended SH3 domain
      cl17036
      Location:489 → 592
      SH3; Src Homology 3 domain superfamily

    6. XM_039102835.2 → XP_038958763.1  FYN-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A6KGF4, A6KGF5
      Conserved Domains (3) summary
      PHA03247
      Location:40 → 416
      PHA03247; large tegument protein UL36; Provisional
      pfam14603
      Location:732 → 820
      hSH3; Helically-extended SH3 domain
      cl17036
      Location:489 → 592
      SH3; Src Homology 3 domain superfamily

    RNA

    1. XR_010063635.1 RNA Sequence

    2. XR_010063636.1 RNA Sequence

    3. XR_005500334.2 RNA Sequence

    4. XR_010063637.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZIE4.2 GenPept UniProtKB/Swiss-Prot:D3ZIE4

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