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    Rin3 Ras and Rab interactor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314397, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Rin3provided by RGD
    Official Full Name
    Ras and Rab interactor 3provided by RGD
    Primary source
    RGD:1305849
    See related
    Ensembl:ENSRNOG00000007062 AllianceGenome:RGD:1305849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in regulation of catalytic activity; signal transduction; and vesicle-mediated transport. Predicted to act upstream of or within negative regulation of receptor internalization and regulation of vesicle size. Predicted to be located in several cellular components, including cytoplasmic vesicle; dendrite; and neuronal cell body. Orthologous to human RIN3 (Ras and Rab interactor 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 59.6), Thymus (RPKM 42.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    6q32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (127196648..127305821)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (121431776..121540956)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (126170672..126279682)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit B1 Neighboring gene cleavage and polyadenylation specific factor 2 Neighboring gene solute carrier family 24 member 4 Neighboring gene uncharacterized LOC134479252 Neighboring gene uncharacterized LOC102548124 Neighboring gene legumain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31. Kajiho H, et al. J Biol Chem, 2011 Jul 8. PMID 21586568, Free PMC Article
    2. FCHo proteins are nucleators of clathrin-mediated endocytosis. Henne WM, et al. Science, 2010 Jun 4. PMID 20448150, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of negative regulation of mast cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of vesicle size ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras and Rab interactor 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108052.2 → NP_001101522.1  ras and Rab interactor 3 isoform 3

      See identical proteins and their annotated locations for NP_001101522.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2K0G9, A0A8I6GJV5, A6JEJ9
      Related
      ENSRNOP00000092596.1, ENSRNOT00000098291.1
      Conserved Domains (3) summary
      pfam02204
      Location:654 → 756
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl00155
      Location:805 → 875
      UBQ; Ubiquitin-like proteins
      cl15255
      Location:1 → 70
      SH2; Src homology 2 (SH2) domain

    2. NM_001414929.1 → NP_001401858.1  ras and Rab interactor 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      D3ZFZ0
      Related
      ENSRNOP00000062921.2, ENSRNOT00000065246.3

    3. NM_001414930.1 → NP_001401859.1  ras and Rab interactor 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      Related
      ENSRNOP00000071441.2, ENSRNOT00000077477.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      127196648..127305821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112360.2 → XP_038968288.1  ras and Rab interactor 3 isoform X1

      Conserved Domains (3) summary
      cd10395
      Location:52 → 153
      SH2_RIN3; Src homology 2 (SH2) domain found in Ras and Rab interactor 3 (RIN3)-like proteins
      PHA03247
      Location:244 → 562
      PHA03247; large tegument protein UL36; Provisional
      cl19569
      Location:736 → 779
      VPS9; Vacuolar sorting protein 9 (VPS9) domain

    2. XM_063261977.1 → XP_063118047.1  ras and Rab interactor 3 isoform X2

    3. XM_039112361.2 → XP_038968289.1  ras and Rab interactor 3 isoform X2

      Conserved Domains (2) summary
      cd16130
      Location:545 → 632
      RA_Rin3; Ras-associating (RA) domain found in Ras and Rab interactor 3 (Rin3)
      pfam02204
      Location:407 → 510
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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