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    Cyp2c68 cytochrome P450, family 2, subfamily c, polypeptide 68 [ Mus musculus (house mouse) ]

    Gene ID: 433247, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Cyp2c68provided by MGI
    Official Full Name
    cytochrome P450, family 2, subfamily c, polypeptide 68provided by MGI
    Primary source
    MGI:MGI:3612287
    See related
    Ensembl:ENSMUSG00000074882 AllianceGenome:MGI:3612287
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9030012A22Rik
    Summary
    Predicted to enable several functions, including caffeine oxidase activity; heme binding activity; and monooxygenase activity. Predicted to be involved in epoxygenase P450 pathway and xenobiotic metabolic process. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; eosinophilic esophagitis; glucose metabolism disease (multiple); invasive aspergillosis; and multiple chemical sensitivity. Orthologous to human CYP2C19 (cytochrome P450 family 2 subfamily C member 19) and CYP2C9 (cytochrome P450 family 2 subfamily C member 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E18 (RPKM 231.9), liver adult (RPKM 187.3) and 5 other tissues See more
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    Genomic context

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    Location:
    19 C3; 19 34.24 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (39677280..39729545, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (39688836..39741101, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 39 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 38 Neighboring gene STARR-seq mESC enhancer starr_46112 Neighboring gene STARR-seq mESC enhancer starr_46113 Neighboring gene STARR-seq mESC enhancer starr_46114 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 67 Neighboring gene STARR-seq mESC enhancer starr_46115 Neighboring gene STARR-seq mESC enhancer starr_46116 Neighboring gene STARR-seq mESC enhancer starr_46117 Neighboring gene STARR-seq mESC enhancer starr_46118 Neighboring gene STARR-seq mESC enhancer starr_46119 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 40 Neighboring gene STARR-seq mESC enhancer starr_46120 Neighboring gene STARR-seq mESC enhancer starr_46121 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 69

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Emergence of complex rearrangements at translocation breakpoints in a transgenic mouse; implications for mechanisms involved in the formation of chromosome rearrangements. Kasai F, et al. Cytogenet Genome Res, 2007. PMID 18160786
    2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arachidonic acid epoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in epoxygenase P450 pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 2, subfamily c, polypeptide 68
    Names
    cytochrome P450 2C40 family

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039555.2 → NP_001034644.2  cytochrome P450, family 2, subfamily c, polypeptide 68 precursor

      Status: VALIDATED

      Source sequence(s)
      AI226521, AI256575, AK136413
      Consensus CDS
      CCDS29797.1
      UniProtKB/TrEMBL
      K7N6C2, Q8VCP4
      Related
      ENSMUSP00000097071.4, ENSMUST00000099472.4
      Conserved Domains (1) summary
      pfam00067
      Location:30 → 487
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      39677280..39729545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527177.2 → XP_006527240.1  cytochrome P450, family 2, subfamily c, polypeptide 68 isoform X1

      UniProtKB/TrEMBL
      Q8VCP4
      Conserved Domains (1) summary
      pfam00067
      Location:1 → 433
      p450; Cytochrome P450
    Nucleotide Protein Strain
    Heading Accession and Version

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