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    Slco1a3 solute carrier organic anion transporter family member 1A3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 80899, updated on 2-May-2024

    Summary

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    Official Symbol
    Slco1a3provided by RGD
    Official Full Name
    solute carrier organic anion transporter family member 1A3provided by RGD
    Primary source
    RGD:621387
    See related
    Ensembl:ENSRNOG00000010388 AllianceGenome:RGD:621387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    OAT-K1; OAT-K2; Slc21a4; rOAT-K1; rOAT-K2; rOAT-K3; rOAT-K5; rOAT-K6; rOAT-K7; rOAT-K8; rOAT-K9; rOAT-K11; rOAT-K13; rOAT-K14
    Summary
    Enables organic anion transmembrane transporter activity. Involved in anion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 775.0) See more
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    Genomic context

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    Location:
    4q44
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (176706205..176749723, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (174975119..175018640, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (176255603..176299119, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family, member 1a1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene solute carrier organic anion transporter family, member 1a6 Neighboring gene solute carrier organic anion transporter family, member 1A5 Neighboring gene islet amyloid polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and tissue-specific expression of spliced variants of the rat organic anion transporter (rOAT-K). Wolff MW, et al. DNA Seq, 2002 Feb. PMID 12180133
    2. Cloning and functional characterization of a new multispecific organic anion transporter, OAT-K2, in rat kidney. Masuda S, et al. Mol Pharmacol, 1999 Apr. PMID 10101033
    3. Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney. Saito H, et al. J Biol Chem, 1996 Aug 23. PMID 8702823
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables bile acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables organic anion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic anion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier organic anion transporter family member 1A3
    Names
    kidney specific organic anion transporter
    rOAT-K
    sodium-independent organic anion transporter K1
    solute carrier family 21 member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030837.2 → NP_110464.2  solute carrier organic anion transporter family member 1A3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0A0MXT4, A6IMQ2
      Related
      ENSRNOP00000000026.5, ENSRNOT00000000026.7
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 625
      oat; sodium-independent organic anion transporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      176706205..176749723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108409.2 → XP_038964337.1  solute carrier organic anion transporter family member 1A3 isoform X8

      UniProtKB/TrEMBL
      A6IMQ4, A6IMR9
      Conserved Domains (1) summary
      TIGR00805
      Location:10 → 468
      oat; sodium-independent organic anion transporter

    2. XM_039108405.2 → XP_038964333.1  solute carrier organic anion transporter family member 1A3 isoform X5

      UniProtKB/TrEMBL
      A6IMQ6, A6IMS1
      Conserved Domains (1) summary
      TIGR00805
      Location:10 → 523
      oat; sodium-independent organic anion transporter

    3. XM_039108406.2 → XP_038964334.1  solute carrier organic anion transporter family member 1A3 isoform X6

      UniProtKB/TrEMBL
      A6IMR1, A6IMR5
      Conserved Domains (1) summary
      TIGR00805
      Location:5 → 509
      oat; sodium-independent organic anion transporter

    4. XM_039108403.2 → XP_038964331.1  solute carrier organic anion transporter family member 1A3 isoform X3

      UniProtKB/TrEMBL
      A6IMR2, A6IMR6
      Conserved Domains (1) summary
      TIGR00805
      Location:5 → 564
      oat; sodium-independent organic anion transporter

    5. XM_063286730.1 → XP_063142800.1  solute carrier organic anion transporter family member 1A3 isoform X7

    6. XM_063286729.1 → XP_063142799.1  solute carrier organic anion transporter family member 1A3 isoform X4

    7. XM_039108402.2 → XP_038964330.1  solute carrier organic anion transporter family member 1A3 isoform X2

      UniProtKB/TrEMBL
      A6IMQ0, A6IMR5
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 570
      oat; sodium-independent organic anion transporter

    8. XM_063286728.1 → XP_063142798.1  solute carrier organic anion transporter family member 1A3 isoform X1

      UniProtKB/TrEMBL
      A6IMQ2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70502.2 GenPept UniProtKB/Swiss-Prot:P70502

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