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    ST7L suppression of tumorigenicity 7 like [ Homo sapiens (human) ]

    Gene ID: 54879, updated on 3-Apr-2024

    Summary

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    Official Symbol
    ST7Lprovided by HGNC
    Official Full Name
    suppression of tumorigenicity 7 likeprovided by HGNC
    Primary source
    HGNC:HGNC:18441
    See related
    Ensembl:ENSG00000007341 MIM:617640; AllianceGenome:HGNC:18441
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ST7R; STLR; FAM4B
    Summary
    This gene was identified by its similarity to the ST7 tumor suppressor gene found in the chromosome 7q31 region. This gene is clustered in a tail-to-tail manner with the WNT2B gene in a chromosomal region known to be deleted and rearranged in a variety of cancers. Several transcript variants encoding many different isoforms have been described, but some have not been fully characterized. [provided by RefSeq, Feb 2011]
    Expression
    Broad expression in testis (RPKM 6.6), skin (RPKM 3.2) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1p13.2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (112517803..112619684, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (112530373..112632344, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113066136..113161763, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1195 Neighboring gene CTTNBP2 N-terminal like Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:112947097-112947622 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:112950375-112950562 Neighboring gene Sharpr-MPRA regulatory region 6417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1513 Neighboring gene MPRA-validated peak369 silencer Neighboring gene microRNA 4256 Neighboring gene Wnt family member 2B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113050855-113051398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1198 Neighboring gene Sharpr-MPRA regulatory region 8072 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1199 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113052323-113052822 Neighboring gene MPRA-validated peak370 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1514 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:113161935-113163134 Neighboring gene mitochondrial ribosomal protein L53 pseudogene 1 Neighboring gene capping actin protein of muscle Z-line subunit alpha 1 Neighboring gene RNA, U7 small nuclear 70 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of ST7R (ST7-like, ST7L) on human chromosome 1p13, a novel gene homologous to tumor suppressor gene ST7 on human chromosome 7q31. Katoh M. Int J Oncol, 2002 Jun. PMID 12012006
    2. MiR-331-3p Links to Drug Resistance of Pancreatic Cancer Cells by Activating WNT/β-Catenin Signal via ST7L. Zhan T, et al. Technol Cancer Res Treat, 2020 Jan-Dec. PMID 32924881, Free PMC Article
    3. Suppression of the proliferation and invasion of breast cancer cells by ST7L occurs through inhibition of activation of Wnt/GSK-3β/β-catenin signalling. Wang H, et al. Clin Exp Pharmacol Physiol, 2020 Jan. PMID 31429477
    4. miR-331-3p functions as an oncogene by targeting ST7L in pancreatic cancer. Chen X, et al. Carcinogenesis, 2018 Jul 30. PMID 29850766
    5. miR-378 functions as an onco-miRNA by targeting the ST7L/Wnt/β-catenin pathway in cervical cancer. Li S, et al. Int J Mol Med, 2017 Oct. PMID 28902356, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-331-3p Links to Drug Resistance of Pancreatic Cancer Cells by Activating WNT/beta-Catenin Signal via ST7L.
      Title: MiR-331-3p Links to Drug Resistance of Pancreatic Cancer Cells by Activating WNT/β-Catenin Signal via ST7L.
    2. Suppression of the proliferation and invasion of breast cancer cells by ST7L occurs through inhibition of activation of Wnt/GSK-3beta/beta-catenin signalling.
      Title: Suppression of the proliferation and invasion of breast cancer cells by ST7L occurs through inhibition of activation of Wnt/GSK-3β/β-catenin signalling.
    3. Study found that miR-331-3p was significantly upregulated in tumor specimens of pancreatic cancer (PC) patients and cell lines. Downregulation of miR-331-3p inhibited PC cell proliferation and epithelial-mesenchymal transition-mediated metastasis in vitro. ST7L was identified as a novel target gene of miR-331-3p. Results demonstrate that miR-331-3p is a tumor-promoting microRNA and a promising biomarker for PC.
      Title: miR-331-3p functions as an oncogene by targeting ST7L in pancreatic cancer.
    4. overexpression of MIR31HG enhanced the expression of suppression of tumorigenicity 7 like (ST7L), which was identified as a downstream target gene of miR-575. Thus, MIR31HG positively regulated ST7L expression through sponging miR-575, and acted as tumor suppressor in hepatocellular carcinoma (HCC).
      Title: Long noncoding RNA MIR31HG inhibits hepatocellular carcinoma proliferation and metastasis by sponging microRNA-575 to modulate ST7L expression.
    5. miR-378 functions as an onco-miRNA by directly downregulating ST7L mRNA and protein level.
      Title: miR-378 functions as an onco-miRNA by targeting the ST7L/Wnt/β-catenin pathway in cervical cancer.
    6. This study revealed important roles of miR-23b and ST7L in progression of Hepatocellular carcinoma.
      Title: MicroRNA-23b functions as an oncogene and activates AKT/GSK3β/β-catenin signaling by targeting ST7L in hepatocellular carcinoma.
    7. miR-24 is a direct regulator of ST7L.
      Title: MiR-24 regulates the proliferation and invasion of glioma by ST7L via β-catenin/Tcf-4 signaling.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11657, FLJ20284

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in negative regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    suppressor of tumorigenicity 7 protein-like
    Names
    ST7-related protein
    tumor suppressor ST7 like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308264.2 → NP_001295193.1  suppressor of tumorigenicity 7 protein-like isoform 7

      See identical proteins and their annotated locations for NP_001295193.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) contains an alternate 5' terminal exon and lacks an alternate exon in its 5' UTR. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (7) that has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AB081317, AK097837, AL109932, AL929470, BC047392, BX537988, BX538338
      Consensus CDS
      CCDS76189.1
      UniProtKB/TrEMBL
      B3KTN0
      Related
      ENSP00000358683.1, ENST00000369669.5
      Conserved Domains (1) summary
      cd11557
      Location:1 → 355
      ST7; Suppression of tumorigenicity 7

    2. NM_017744.5 → NP_060214.2  suppressor of tumorigenicity 7 protein-like isoform 1

      See identical proteins and their annotated locations for NP_060214.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AB081317, AL109932, BX538338
      Consensus CDS
      CCDS848.1
      UniProtKB/Swiss-Prot
      A8K4S7, Q49AH6, Q5TEI4, Q5U5K6, Q6N067, Q7Z2Z0, Q7Z3C2, Q8N7P8, Q8TDW1, Q8TDW2, Q8TDW3, Q8TDW4, Q9NXF3
      UniProtKB/TrEMBL
      B7Z3J2
      Related
      ENSP00000350734.4, ENST00000358039.9
      Conserved Domains (1) summary
      pfam04184
      Location:43 → 552
      ST7; ST7 protein

    3. NM_138727.4 → NP_620055.1  suppressor of tumorigenicity 7 protein-like isoform 2

      See identical proteins and their annotated locations for NP_620055.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in an isoform (2) that is missing an internal region, as compared to isoform 1.
      Source sequence(s)
      AB081318, AL109932, BX538338
      Consensus CDS
      CCDS849.1
      UniProtKB/TrEMBL
      B7Z3J2
      Related
      ENSP00000417140.1, ENST00000490067.5
      Conserved Domains (1) summary
      cd11557
      Location:69 → 521
      ST7; Suppression of tumorigenicity 7

    4. NM_138728.3 → NP_620056.1  suppressor of tumorigenicity 7 protein-like isoform 3

      See identical proteins and their annotated locations for NP_620056.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame segment, compared to variant 1, resulting in an isoform (3) that is missing an internal region, as compared to isoform 1.
      Source sequence(s)
      AB081319, AL109932, BX538338
      Consensus CDS
      CCDS850.1
      UniProtKB/TrEMBL
      B7Z3J2
      Related
      ENSP00000353972.4, ENST00000360743.8
      Conserved Domains (1) summary
      cd11557
      Location:72 → 507
      ST7; Suppression of tumorigenicity 7

    5. NM_138729.4 → NP_620057.1  suppressor of tumorigenicity 7 protein-like isoform 4

      See identical proteins and their annotated locations for NP_620057.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, when compared to variant 1, resulting in an isoform (4) that has a distinct and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AB081320, AL109932, BC027898
      Consensus CDS
      CCDS852.1
      UniProtKB/TrEMBL
      B7Z7D4
      Related
      ENSP00000345312.7, ENST00000343210.11
      Conserved Domains (1) summary
      cd11557
      Location:72 → 538
      ST7; Suppression of tumorigenicity 7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      112517803..112619684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541628.3 → XP_011539930.1  suppressor of tumorigenicity 7 protein-like isoform X2

      UniProtKB/TrEMBL
      B7Z7D4
      Conserved Domains (1) summary
      cd11557
      Location:72 → 538
      ST7; Suppression of tumorigenicity 7

    2. XM_011541631.4 → XP_011539933.1  suppressor of tumorigenicity 7 protein-like isoform X6

      See identical proteins and their annotated locations for XP_011539933.1

      UniProtKB/TrEMBL
      B7Z7D4
      Conserved Domains (1) summary
      cd11557
      Location:12 → 416
      ST7; Suppression of tumorigenicity 7

    3. XM_047423352.1 → XP_047279308.1  suppressor of tumorigenicity 7 protein-like isoform X6

    4. XM_047423341.1 → XP_047279297.1  suppressor of tumorigenicity 7 protein-like isoform X1

      UniProtKB/Swiss-Prot
      A8K4S7, Q49AH6, Q5TEI4, Q5U5K6, Q6N067, Q7Z2Z0, Q7Z3C2, Q8N7P8, Q8TDW1, Q8TDW2, Q8TDW3, Q8TDW4, Q9NXF3
      Related
      ENSP00000436544.1, ENST00000490715.5

    5. XM_047423368.1 → XP_047279324.1  suppressor of tumorigenicity 7 protein-like isoform X9

    6. XM_047423372.1 → XP_047279328.1  suppressor of tumorigenicity 7 protein-like isoform X6

    7. XM_047423358.1 → XP_047279314.1  suppressor of tumorigenicity 7 protein-like isoform X6

    8. XM_047423351.1 → XP_047279307.1  suppressor of tumorigenicity 7 protein-like isoform X5

    9. XM_047423350.1 → XP_047279306.1  suppressor of tumorigenicity 7 protein-like isoform X4

    10. XM_011541629.3 → XP_011539931.1  suppressor of tumorigenicity 7 protein-like isoform X3

      UniProtKB/TrEMBL
      B7Z7D4
      Conserved Domains (1) summary
      cd11557
      Location:16 → 482
      ST7; Suppression of tumorigenicity 7

    11. XM_047423374.1 → XP_047279330.1  suppressor of tumorigenicity 7 protein-like isoform X12

    12. XM_047423373.1 → XP_047279329.1  suppressor of tumorigenicity 7 protein-like isoform X11

    13. XM_047423369.1 → XP_047279325.1  suppressor of tumorigenicity 7 protein-like isoform X10

    14. XM_017001535.2 → XP_016857024.1  suppressor of tumorigenicity 7 protein-like isoform X8

      UniProtKB/TrEMBL
      B7Z8V6

    15. XM_047423363.1 → XP_047279319.1  suppressor of tumorigenicity 7 protein-like isoform X7

    RNA

    1. XR_007061293.1 RNA Sequence

    2. XR_007061292.1 RNA Sequence

    3. XR_007061291.1 RNA Sequence

    4. XR_946675.3 RNA Sequence

    5. XR_007061297.1 RNA Sequence

    6. XR_007061295.1 RNA Sequence

    7. XR_007061296.1 RNA Sequence

    8. XR_007061294.1 RNA Sequence

    9. XR_007061298.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      112530373..112632344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337233.1 → XP_054193208.1  suppressor of tumorigenicity 7 protein-like isoform X2

    2. XM_054337238.1 → XP_054193213.1  suppressor of tumorigenicity 7 protein-like isoform X6

    3. XM_054337242.1 → XP_054193217.1  suppressor of tumorigenicity 7 protein-like isoform X9

    4. XM_054337244.1 → XP_054193219.1  suppressor of tumorigenicity 7 protein-like isoform X6

    5. XM_054337239.1 → XP_054193214.1  suppressor of tumorigenicity 7 protein-like isoform X6

    6. XM_054337237.1 → XP_054193212.1  suppressor of tumorigenicity 7 protein-like isoform X5

    7. XM_054337236.1 → XP_054193211.1  suppressor of tumorigenicity 7 protein-like isoform X4

    8. XM_054337235.1 → XP_054193210.1  suppressor of tumorigenicity 7 protein-like isoform X3

    9. XM_054337246.1 → XP_054193221.1  suppressor of tumorigenicity 7 protein-like isoform X12

    10. XM_054337245.1 → XP_054193220.1  suppressor of tumorigenicity 7 protein-like isoform X11

    11. XM_054337234.1 → XP_054193209.1  suppressor of tumorigenicity 7 protein-like isoform X14

    12. XM_054337232.1 → XP_054193207.1  suppressor of tumorigenicity 7 protein-like isoform X13

    13. XM_054337243.1 → XP_054193218.1  suppressor of tumorigenicity 7 protein-like isoform X10

    14. XM_054337241.1 → XP_054193216.1  suppressor of tumorigenicity 7 protein-like isoform X8

    15. XM_054337240.1 → XP_054193215.1  suppressor of tumorigenicity 7 protein-like isoform X7

    RNA

    1. XR_008486070.1 RNA Sequence

    2. XR_008486074.1 RNA Sequence

    3. XR_008486072.1 RNA Sequence

    4. XR_008486073.1 RNA Sequence

    5. XR_008486071.1 RNA Sequence

    6. XR_008486075.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198327.1: Suppressed sequence

      Description
      NM_198327.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate and the protein also lacks homolog support.

    2. NM_198328.1: Suppressed sequence

      Description
      NM_198328.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate and the protein also lacks homolog support.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TDW4.1 GenPept UniProtKB/Swiss-Prot:Q8TDW4

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