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    TRIO trio Rho guanine nucleotide exchange factor [ Homo sapiens (human) ]

    Gene ID: 7204, updated on 11-Apr-2024

    Summary

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    Official Symbol
    TRIOprovided by HGNC
    Official Full Name
    trio Rho guanine nucleotide exchange factorprovided by HGNC
    Primary source
    HGNC:HGNC:12303
    See related
    Ensembl:ENSG00000038382 MIM:601893; AllianceGenome:HGNC:12303
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    tgat; MEBAS; MRD44; MRD63; ARHGEF23
    Summary
    This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
    Expression
    Ubiquitous expression in brain (RPKM 8.0), spleen (RPKM 6.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    5p15.2
    Exon count:
    61
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (14143342..14510204)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (14080499..14449245)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (14143451..14510313)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 pseudogene 13 Neighboring gene meiotic recombination hotspot J Neighboring gene dynein axonemal heavy chain 5 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:13858976-13860175 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15932 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:14034965-14035492 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:14035876-14037075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:14055383-14055883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15933 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:14108867-14110066 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:14118635-14119191 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:14119192-14119747 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:14125559-14126060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15939 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15938 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22387 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22388 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:14174256-14174781 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22389 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22390 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22391 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22396 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:14254265-14254435 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22399 Neighboring gene Sharpr-MPRA regulatory region 5150 Neighboring gene uncharacterized LOC124900943 Neighboring gene OCT4 hESC enhancer GRCh37_chr5:14346974-14347475 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:14358109-14358798 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:14399912-14401111 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:14406263-14407462 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:14417547-14418093 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:14445485-14446012 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:14446013-14446539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22401 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22403 Neighboring gene Sharpr-MPRA regulatory region 14564 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:14465686-14465857 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:14497716-14498915 Neighboring gene small nucleolar RNA, C/D box 170 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:14521506-14522006 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:14522007-14522507 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:14577633-14578133 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15941 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22404 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22406 Neighboring gene pleckstrin homology domain containing A1 pseudogene Neighboring gene OTU deubiquitinase with linear linkage specificity like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Autoinhibition of the GEF activity of cytoskeletal regulatory protein Trio is disrupted in neurodevelopmental disorder-related genetic variants. Bircher JE, et al. J Biol Chem, 2022 Sep. PMID 35963430, Free PMC Article
    2. More evidence on TRIO missense mutations in the spectrin repeat domain causing severe developmental delay and recognizable facial dysmorphism with macrocephaly. Kloth K, et al. Neurogenetics, 2021 Jul. PMID 34013494
    3. Novel loss-of-function variants in TRIO are associated with neurodevelopmental disorder: case report. Schultz-Rogers L, et al. BMC Med Genet, 2020 Nov 10. PMID 33167890, Free PMC Article
    4. Genetics of physiological dysregulation: findings from the long life family study using joint models. Arbeev KG, et al. Aging (Albany NY), 2020 Apr 1. PMID 32235003, Free PMC Article
    5. The Role of Trio, a Rho Guanine Nucleotide Exchange Factor, in Glomerular Podocytes. Maier M, et al. Int J Mol Sci, 2018 Feb 6. PMID 29415466, Free PMC Article

    See all (112) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Detection of autism spectrum disorder-related pathogenic trio variants by a novel structure-based approach.
      Title: Detection of autism spectrum disorder-related pathogenic trio variants by a novel structure-based approach.
    2. Pathogenic TRIO variants associated with neurodevelopmental disorders perturb the molecular regulation of TRIO and axon pathfinding in vivo.
      Title: Pathogenic TRIO variants associated with neurodevelopmental disorders perturb the molecular regulation of TRIO and axon pathfinding in vivo.
    3. Autoinhibition of the GEF activity of cytoskeletal regulatory protein Trio is disrupted in neurodevelopmental disorder-related genetic variants.
      Title: Autoinhibition of the GEF activity of cytoskeletal regulatory protein Trio is disrupted in neurodevelopmental disorder-related genetic variants.
    4. Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1.
      Title: Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1.
    5. Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoA.
      Title: Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoA.
    6. More evidence on TRIO missense mutations in the spectrin repeat domain causing severe developmental delay and recognizable facial dysmorphism with macrocephaly.
      Title: More evidence on TRIO missense mutations in the spectrin repeat domain causing severe developmental delay and recognizable facial dysmorphism with macrocephaly.
    7. Complex interactions between the angiotensin II type 1 receptor, the epidermal growth factor receptor and TRIO-dependent signaling partners.
      Title: Complex interactions between the angiotensin II type 1 receptor, the epidermal growth factor receptor and TRIO-dependent signaling partners.
    8. Genetics of physiological dysregulation: findings from the long life family study using joint models.
      Title: Genetics of physiological dysregulation: findings from the long life family study using joint models.
    9. Novel loss-of-function variants in TRIO are associated with neurodevelopmental disorder: case report.
      Title: Novel loss-of-function variants in TRIO are associated with neurodevelopmental disorder: case report.
    10. The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled.
      Title: The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled.
    Submit: New GeneRIF Correction See all GeneRIFs (43)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2018-01-24)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2018-01-24)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.
    EBI GWAS Catalog
    Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ42780

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine phosphatase signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in postsynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extrinsic component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic active zone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    triple functional domain protein
    Names
    PTPRF-interacting protein
    triple functional domain (PTPRF interacting)
    NP_009049.2
    XP_011512409.1
    XP_011512410.1
    XP_011512411.1
    XP_011512412.1
    XP_016865290.1
    XP_016865291.1
    XP_016865292.1
    XP_047273635.1
    XP_047273637.1
    XP_054209360.1
    XP_054209361.1
    XP_054209362.1
    XP_054209363.1
    XP_054209364.1
    XP_054209365.1
    XP_054209366.1
    XP_054209367.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052962.1 RefSeqGene

      Range
      4641..371503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_007118.4 → NP_009049.2  triple functional domain protein

      See identical proteins and their annotated locations for NP_009049.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
      Source sequence(s)
      AC010419, AF091395, AI478154, AK131423, BC017268, BC035585, BF058117, BQ184284, BQ691537, U42390
      Consensus CDS
      CCDS3883.1
      UniProtKB/Swiss-Prot
      D3DTD1, O75962, Q13458, Q59EQ7, Q6PJC9, Q6ZN05, Q8IWK8
      UniProtKB/TrEMBL
      A0A2X0SFJ0
      Related
      ENSP00000339299.4, ENST00000344204.9
      Conserved Domains (14) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1659 → 1718
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2555 → 2613
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:2796 → 3050
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:69 → 204
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1970 → 2143
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:567 → 783
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:2685 → 2776
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:1472 → 1594
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2148 → 2286
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14113
      Location:2788 → 3050
      STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
      pfam00169
      Location:2175 → 2271
      PH; PH domain
      pfam16609
      Location:1715 → 1972
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl11960
      Location:2699 → 2776
      Ig; Immunoglobulin domain

    RNA

    1. NR_134469.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site at an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC010419, AF091395, AI478154, AK131423, BC017268, BC035585, BF058117, BQ184284, BQ691537, U42390
      Related
      ENST00000512070.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      14143342..14510204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417679.1 → XP_047273635.1  triple functional domain protein isoform X2

    2. XM_017009802.2 → XP_016865291.1  triple functional domain protein isoform X6

      UniProtKB/TrEMBL
      A0A2X0SFJ0
      Related
      ENSP00000426342.2, ENST00000513206.5

    3. XM_017009801.2 → XP_016865290.1  triple functional domain protein isoform X1

      UniProtKB/TrEMBL
      A0A2X0SFJ0

    4. XM_047417681.1 → XP_047273637.1  triple functional domain protein isoform X7

    5. XM_011514110.4 → XP_011512412.1  triple functional domain protein isoform X5

      See identical proteins and their annotated locations for XP_011512412.1

      UniProtKB/TrEMBL
      A0A2X0SFJ0
      Conserved Domains (14) summary
      smart00150
      Location:1084 → 1184
      SPEC; Spectrin repeats
      cd11852
      Location:1600 → 1659
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2496 → 2554
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:2737 → 2991
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:10 → 145
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1911 → 2084
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:508 → 724
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:2626 → 2717
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:1413 → 1535
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2089 → 2227
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14113
      Location:2729 → 2991
      STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
      pfam00169
      Location:2116 → 2212
      PH; PH domain
      pfam16609
      Location:1656 → 1913
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl11960
      Location:2640 → 2717
      Ig; Immunoglobulin domain

    6. XM_011514108.2 → XP_011512410.1  triple functional domain protein isoform X3

      UniProtKB/TrEMBL
      A0A2X0SFJ0
      Conserved Domains (14) summary
      smart00150
      Location:1104 → 1204
      SPEC; Spectrin repeats
      cd11852
      Location:1620 → 1679
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2516 → 2574
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:2757 → 3011
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:30 → 165
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1931 → 2104
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:528 → 744
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:2646 → 2737
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:1433 → 1555
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2109 → 2247
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14113
      Location:2749 → 3011
      STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
      pfam00169
      Location:2136 → 2232
      PH; PH domain
      pfam16609
      Location:1676 → 1933
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl11960
      Location:2660 → 2737
      Ig; Immunoglobulin domain

    7. XM_011514109.4 → XP_011512411.1  triple functional domain protein isoform X4

      UniProtKB/TrEMBL
      A0A2X0SFJ0
      Conserved Domains (14) summary
      smart00150
      Location:1094 → 1194
      SPEC; Spectrin repeats
      cd11852
      Location:1610 → 1669
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2506 → 2564
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:2747 → 3001
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:20 → 155
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1921 → 2094
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:518 → 734
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:2636 → 2727
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:1423 → 1545
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2099 → 2237
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14113
      Location:2739 → 3001
      STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
      pfam00169
      Location:2126 → 2222
      PH; PH domain
      pfam16609
      Location:1666 → 1923
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl11960
      Location:2650 → 2727
      Ig; Immunoglobulin domain

    8. XM_011514107.3 → XP_011512409.1  triple functional domain protein isoform X2

      UniProtKB/TrEMBL
      A0A2X0SFJ0
      Conserved Domains (14) summary
      smart00150
      Location:1122 → 1222
      SPEC; Spectrin repeats
      cd11852
      Location:1638 → 1697
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2534 → 2592
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:2775 → 3029
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:48 → 183
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1949 → 2122
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:546 → 762
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:2664 → 2755
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:1451 → 1573
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2127 → 2265
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14113
      Location:2767 → 3029
      STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
      pfam00169
      Location:2154 → 2250
      PH; PH domain
      pfam16609
      Location:1694 → 1951
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl11960
      Location:2678 → 2755
      Ig; Immunoglobulin domain

    9. XM_017009803.2 → XP_016865292.1  triple functional domain protein isoform X8

      UniProtKB/TrEMBL
      A0A2X0SFJ0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      14080499..14449245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353386.1 → XP_054209361.1  triple functional domain protein isoform X2

    2. XM_054353390.1 → XP_054209365.1  triple functional domain protein isoform X6

    3. XM_054353385.1 → XP_054209360.1  triple functional domain protein isoform X1

    4. XM_054353391.1 → XP_054209366.1  triple functional domain protein isoform X7

    5. XM_054353389.1 → XP_054209364.1  triple functional domain protein isoform X5

    6. XM_054353387.1 → XP_054209362.1  triple functional domain protein isoform X3

    7. XM_054353388.1 → XP_054209363.1  triple functional domain protein isoform X4

    8. XM_054353392.1 → XP_054209367.1  triple functional domain protein isoform X8

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75962.2 GenPept UniProtKB/Swiss-Prot:O75962

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