Aifm3 apoptosis-inducing factor, mitochondrion-associated 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aifm3provided by MGI
Official Full Name: apoptosis-inducing factor, mitochondrion-associated 3provided by MGI
Primary source: MGI:MGI:1919418
See related: Ensembl:ENSMUSG00000022763 AllianceGenome:MGI:1919418
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aifl; 2810401C16Rik
Summary: Predicted to enable oxidoreductase activity, acting on NAD(P)H. Predicted to be involved in execution phase of apoptosis. Predicted to act upstream of or within apoptotic process. Located in mitochondrion. Is expressed in heart. Orthologous to human AIFM3 (apoptosis inducing factor mitochondria associated 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 65.0), cortex adult (RPKM 36.8) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A3; 16 10.84 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (17307418..17325349)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (17489624..17507485)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AIF-deficient mice display similar rates of H2O2 release and protein carbonyl modifications in brain mitochondria compared to WT controls
Title: Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on NAD(P)H	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in execution phase of apoptosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in execution phase of apoptosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: apoptosis-inducing factor 3

Names: apoptosis-inducing factor like; apoptosis-inducing factor-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291070.1 → NP_001277999.1 apoptosis-inducing factor 3 isoform 1

See identical proteins and their annotated locations for NP_001277999.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AI835101, AK012958, AK158809

Consensus CDS

CCDS79430.1

UniProtKB/Swiss-Prot

Q0VBD6, Q3TY86, Q4VAA4, Q8BWV0

Related

ENSMUSP00000111349.2, ENSMUST00000115685.10

Conserved Domains (3) summary

cd03478
Location:70 → 163

Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...

pfam07992
Location:198 → 493

Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

pfam14759
Location:512 → 562

Reductase_C; Reductase C-terminal
NM_175178.4 → NP_780387.2 apoptosis-inducing factor 3 isoform 2

See identical proteins and their annotated locations for NP_780387.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame alternate exon in the 3' coding region, compared to variant 1. It encodes a shorter isoform (2), compared to isoform 1.

Source sequence(s)

AK158809, BY255255, CD742217

Consensus CDS

CCDS28003.1

UniProtKB/Swiss-Prot

Q3TY86

Related

ENSMUSP00000023448.7, ENSMUST00000023448.15

Conserved Domains (5) summary

cd03478
Location:70 → 163

Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...

pfam00070
Location:334 → 414

Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase

pfam07992
Location:195 → 493

Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

pfam14759
Location:512 → 562

Reductase_C; Reductase C-terminal

cl21454
Location:196 → 285

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

17307418..17325349

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522595.4 → XP_006522658.1 apoptosis-inducing factor 3 isoform X7

See identical proteins and their annotated locations for XP_006522658.1

Conserved Domains (2) summary

cd03478
Location:70 → 163

Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...

pfam07992
Location:195 → 493

Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
XM_036160135.1 → XP_036016028.1 apoptosis-inducing factor 3 isoform X7

Conserved Domains (2) summary

cd03478
Location:70 → 163

Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...

pfam07992
Location:195 → 493

Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
XM_006522590.4 → XP_006522653.1 apoptosis-inducing factor 3 isoform X1

See identical proteins and their annotated locations for XP_006522653.1

Conserved Domains (3) summary

cd03478
Location:70 → 163

Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...

pfam07992
Location:198 → 493

Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

pfam14759
Location:512 → 562

Reductase_C; Reductase C-terminal
XM_006522592.4 → XP_006522655.1 apoptosis-inducing factor 3 isoform X2

See identical proteins and their annotated locations for XP_006522655.1

UniProtKB/Swiss-Prot

Q0VBD6, Q3TY86, Q4VAA4, Q8BWV0

Conserved Domains (3) summary

cd03478
Location:70 → 163

Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...

pfam07992
Location:198 → 493

Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

pfam14759
Location:512 → 562

Reductase_C; Reductase C-terminal
XM_036160134.1 → XP_036016027.1 apoptosis-inducing factor 3 isoform X6

Conserved Domains (3) summary

cd03478
Location:70 → 163

Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...

pfam07992
Location:195 → 493

Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

pfam14759
Location:512 → 553

Reductase_C; Reductase C-terminal
XM_006522594.4 → XP_006522657.1 apoptosis-inducing factor 3 isoform X5

Conserved Domains (2) summary

cd03478
Location:70 → 163

Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...

pfam07992
Location:198 → 493

Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
XM_006522593.4 → XP_006522656.1 apoptosis-inducing factor 3 isoform X3

Conserved Domains (3) summary

cd03478
Location:70 → 156

Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...

pfam07992
Location:183 → 478

Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

pfam14759
Location:497 → 547

Reductase_C; Reductase C-terminal
XM_036160133.1 → XP_036016026.1 apoptosis-inducing factor 3 isoform X4

Conserved Domains (3) summary

cd03478
Location:70 → 156

Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...

pfam07992
Location:180 → 478

Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

pfam14759
Location:497 → 547

Reductase_C; Reductase C-terminal
XM_006522591.4 → XP_006522654.1 apoptosis-inducing factor 3 isoform X1

See identical proteins and their annotated locations for XP_006522654.1

Conserved Domains (3) summary

cd03478
Location:70 → 163

Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...

pfam07992
Location:198 → 493

Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

pfam14759
Location:512 → 562

Reductase_C; Reductase C-terminal
XM_036160136.1 → XP_036016029.1 apoptosis-inducing factor 3 isoform X8

Conserved Domains (3) summary

cd03478
Location:1 → 81

Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...

pfam07992
Location:113 → 411

Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

pfam14759
Location:430 → 480

Reductase_C; Reductase C-terminal