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    Smap2 small ArfGAP 2 [ Mus musculus (house mouse) ]

    Gene ID: 69780, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Smap2provided by MGI
    Official Full Name
    small ArfGAP 2provided by MGI
    Primary source
    MGI:MGI:1917030
    See related
    Ensembl:ENSMUSG00000032870 AllianceGenome:MGI:1917030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Smap1l; 1810031K02Rik
    Summary
    Predicted to enable GTPase activator activity. Predicted to be located in cytoplasm. Is expressed in several structures, including central nervous system and ganglia. Orthologous to human SMAP2 (small ArfGAP2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in spleen adult (RPKM 26.9), frontal lobe adult (RPKM 20.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D2.2; 4 56.7 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (120825514..120874497, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (120968317..121017289, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10254 Neighboring gene STARR-positive B cell enhancer ABC_E6207 Neighboring gene exonuclease 5 Neighboring gene zinc finger protein 69 Neighboring gene STARR-positive B cell enhancer ABC_E6208 Neighboring gene STARR-positive B cell enhancer ABC_E4659 Neighboring gene microRNA 7015 Neighboring gene STARR-positive B cell enhancer ABC_E6209 Neighboring gene STARR-positive B cell enhancer ABC_E3508 Neighboring gene STARR-positive B cell enhancer ABC_E10255 Neighboring gene STARR-positive B cell enhancer ABC_E6210 Neighboring gene STARR-seq mESC enhancer starr_11259 Neighboring gene collagen, type IX, alpha 2 Neighboring gene zinc metallopeptidase, STE24 Neighboring gene predicted gene, 23540

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Arf GAP SMAP2 is necessary for organized vesicle budding from the trans-Golgi network and subsequent acrosome formation in spermiogenesis. Funaki T, et al. Mol Biol Cell, 2013 Sep. PMID 23864717, Free PMC Article
    2. Localization of SMAP2 to the TGN and its function in the regulation of TGN protein transport. Funaki T, et al. Cell Struct Funct, 2011. PMID 21368446
    3. Mice doubly-deficient in the Arf GAPs SMAP1 and SMAP2 exhibit embryonic lethality. Sumiyoshi M, et al. FEBS Lett, 2015 Sep 14. PMID 26296315
    4. SMAP2, a novel ARF GTPase-activating protein, interacts with clathrin and clathrin assembly protein and functions on the AP-1-positive early endosome/trans-Golgi network. Natsume W, et al. Mol Biol Cell, 2006 Jun. PMID 16571680, Free PMC Article
    5. Genomic strategy identifies a missense mutation in WD-repeat domain 65 (WDR65) in an individual with Van der Woude syndrome. Rorick NK, et al. Am J Med Genet A, 2011 Jun. PMID 21574244, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. either SMAP1 or SMAP2, is required for proper embryogenesis
      Title: Mice doubly-deficient in the Arf GAPs SMAP1 and SMAP2 exhibit embryonic lethality.
    2. study reveals a link between SMAP2 and CALM/syntaxin2 in clathrin-coated vesicle formation from the trans-Golgi network and subsequent acrosome formation
      Title: The Arf GAP SMAP2 is necessary for organized vesicle budding from the trans-Golgi network and subsequent acrosome formation in spermiogenesis.
    3. the trans-Golgi network (TGN) was verified as an additional site of SMAP2 localization based on its co-localization with various TGN-marker proteins.
      Title: Localization of SMAP2 to the TGN and its function in the regulation of TGN protein transport.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    stromal membrane-associated protein 2
    Names
    stromal membrane-associated GTPase-activating protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133716.3 → NP_598477.2  stromal membrane-associated protein 2

      See identical proteins and their annotated locations for NP_598477.2

      Status: VALIDATED

      Source sequence(s)
      BC052413, BM944792, BQ175680
      Consensus CDS
      CCDS18598.1
      UniProtKB/Swiss-Prot
      Q3U798, Q7TN29
      Related
      ENSMUSP00000035800.8, ENSMUST00000043200.8
      Conserved Domains (2) summary
      pfam01412
      Location:13 → 126
      ArfGap; Putative GTPase activating protein for Arf
      pfam09606
      Location:276 → 416
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      120825514..120874497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503378.4 → XP_006503441.1  stromal membrane-associated protein 2 isoform X1

      Conserved Domains (2) summary
      pfam09606
      Location:196 → 336
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl28907
      Location:1 → 42
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)

    2. XM_006503379.4 → XP_006503442.1  stromal membrane-associated protein 2 isoform X2

      Conserved Domains (1) summary
      pfam09606
      Location:195 → 335
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    3. XM_006503380.3 → XP_006503443.1  stromal membrane-associated protein 2 isoform X3

      Conserved Domains (1) summary
      cd08859
      Location:16 → 122
      ArfGap_SMAP2; Stromal membrane-associated protein 2; a subfamily of the ArfGAP family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TN29.1 GenPept UniProtKB/Swiss-Prot:Q7TN29

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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