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    Ppp2r2c protein phosphatase 2, regulatory subunit B, gamma [ Mus musculus (house mouse) ]

    Gene ID: 269643, updated on 16-Apr-2024

    Summary

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    Official Symbol
    Ppp2r2cprovided by MGI
    Official Full Name
    protein phosphatase 2, regulatory subunit B, gammaprovided by MGI
    Primary source
    MGI:MGI:2442660
    See related
    Ensembl:ENSMUSG00000029120 AllianceGenome:MGI:2442660
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PR52; IMYPNO; IMYPNO1; 6330548O06Rik
    Summary
    Predicted to enable protein phosphatase regulator activity. Predicted to be involved in peptidyl-serine dephosphorylation. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol. Is expressed in inner cell mass; pelvic ganglion; urethra of female; and urethra of male. Orthologous to human PPP2R2C (protein phosphatase 2 regulatory subunit Bgamma). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 105.0), frontal lobe adult (RPKM 88.2) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 B3; 5 19.28 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (37024187..37112422)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (36866846..36955078)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Morf4 family associated protein 1 Neighboring gene STARR-positive B cell enhancer mm9_chr5:37221807-37222107 Neighboring gene mannosidase 2, alpha B2 Neighboring gene predicted gene, 52812 Neighboring gene protein phosphatase 2, regulatory subunit B, gamma, opposite strand Neighboring gene STARR-seq mESC enhancer starr_12887 Neighboring gene STARR-seq mESC enhancer starr_12890 Neighboring gene predicted gene, 52813 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37370903-37371090 Neighboring gene STARR-positive B cell enhancer ABC_E6324 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37380607-37380790 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37389242-37389505 Neighboring gene STARR-seq mESC enhancer starr_12893 Neighboring gene wolframin ER transmembrane glycoprotein Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37436048-37436298 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37438571-37438789 Neighboring gene janus kinase and microtubule interacting protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37442129-37442330 Neighboring gene isocitrate dehydrogenase 3 (NAD+) beta pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PP2A subunit PPP2R2C is downregulated in the brains of Alzheimer's transgenic mice. Leong W, et al. Aging (Albany NY), 2020 Apr 14. PMID 32291379, Free PMC Article
    2. Dopamine D2 receptors' effects on renal inflammation are mediated by regulation of PP2A function. Zhang Y, et al. Am J Physiol Renal Physiol, 2016 Jan 15. PMID 26290374, Free PMC Article
    3. PP2A Inactivation Mediated by PPP2R4 Haploinsufficiency Promotes Cancer Development. Sents W, et al. Cancer Res, 2017 Dec 15. PMID 29046336
    4. Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development. O'Shaughnessy RF, et al. Development, 2009 Oct. PMID 19762425, Free PMC Article
    5. Transcription Factors Sp8 and Sp9 Regulate Medial Ganglionic Eminence-Derived Cortical Interneuron Migration. Tao G, et al. Front Mol Neurosci, 2019. PMID 31001083, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PP2A subunit PPP2R2C is downregulated in the brains of Alzheimer's transgenic mice.
      Title: PP2A subunit PPP2R2C is downregulated in the brains of Alzheimer's transgenic mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
    NP_001346932.1
    NP_766582.1
    XP_006504034.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360003.1 → NP_001346932.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC115722, AC169036
      Conserved Domains (2) summary
      COG5170
      Location:8 → 424
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:13 → 61
      7WD40; WD40 repeat [structural motif]

    2. NM_172994.4 → NP_766582.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform 1

      See identical proteins and their annotated locations for NP_766582.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC115722, AC169036
      Consensus CDS
      CCDS19244.1
      UniProtKB/Swiss-Prot
      Q8BG02
      Related
      ENSMUSP00000031003.8, ENSMUST00000031003.11
      Conserved Domains (3) summary
      COG5170
      Location:21 → 438
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:27 → 75
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:15 → 366
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      37024187..37112422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503971.4 → XP_006504034.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform X1

      Conserved Domains (2) summary
      COG5170
      Location:75 → 490
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:79 → 127
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BG02.1 GenPept UniProtKB/Swiss-Prot:Q8BG02

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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