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    ZNF79 zinc finger protein 79 [ Homo sapiens (human) ]

    Gene ID: 7633, updated on 11-Apr-2024

    Summary

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    Official Symbol
    ZNF79provided by HGNC
    Official Full Name
    zinc finger protein 79provided by HGNC
    Primary source
    HGNC:HGNC:13153
    See related
    Ensembl:ENSG00000196152 MIM:194552; AllianceGenome:HGNC:13153
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    pT7
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 3.5), thyroid (RPKM 1.9) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    9q33.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (127424382..127445372)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (139631324..139652321)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130186661..130207651)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene GTPase activating Rap/RanGAP domain like 3 Neighboring gene uncharacterized LOC124902275 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130146967-130147700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20303 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130168662-130169228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130180180-130180827 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130180828-130181474 Neighboring gene solute carrier family 2 member 8 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:130185748-130186690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29040 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:130211857-130212400 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130212943-130213486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29041 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29042 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130226533-130227033 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130226032-130226532 Neighboring gene small nucleolar RNA, H/ACA box 65 Neighboring gene ribosomal protein L12 Neighboring gene leucine rich repeat and sterile alpha motif containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130251390-130251970 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130251971-130252551 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130256483-130257002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130262849-130263350

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets. Gonsky R, et al. Nucleic Acids Res, 1997 Oct 1. PMID 9380504, Free PMC Article
    2. Chromosomal localization of four human zinc finger cDNAs. Huebner K, et al. Hum Genet, 1993 Apr. PMID 8478004
    3. Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19. Rousseau-Merck MF, et al. Hum Genet, 1993 Dec. PMID 8262519
    4. The zinc finger-associated SCAN box is a conserved oligomerization domain. Williams AJ, et al. Mol Cell Biol, 1999 Dec. PMID 10567577, Free PMC Article
    5. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Liu C, et al. Cancer Res, 2019 May 1. PMID 30862715, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 79
    Names
    ZNFpT7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286696.2 → NP_001273625.1  zinc finger protein 79 isoform b

      See identical proteins and their annotated locations for NP_001273625.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' terminal exon, and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
      Source sequence(s)
      AI301044, AK302284, AK316233, DA001397
      Consensus CDS
      CCDS69664.1
      UniProtKB/TrEMBL
      F5H032
      Related
      ENSP00000478201.1, ENST00000612342.4
      Conserved Domains (4) summary
      COG5048
      Location:182 → 413
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:171 → 191
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:435 → 460
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:16 → 74
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    2. NM_001286697.2 → NP_001273626.1  zinc finger protein 79 isoform b

      See identical proteins and their annotated locations for NP_001273626.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes an additional exon in the 5' region, and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
      Source sequence(s)
      AI301044, AK302284, AK316233, DA001397
      Consensus CDS
      CCDS69664.1
      UniProtKB/TrEMBL
      F5H032
      Related
      ENSP00000438418.1, ENST00000543471.5
      Conserved Domains (4) summary
      COG5048
      Location:182 → 413
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:171 → 191
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:435 → 460
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:16 → 74
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    3. NM_001286698.2 → NP_001273627.1  zinc finger protein 79 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' terminal exon and lacks two alternate exons in the 5' region, and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AI301044, AK302284, AK316233, BP248437, DA001397
      Consensus CDS
      CCDS75904.1
      UniProtKB/TrEMBL
      A0A087X2B0
      Related
      ENSP00000484833.1, ENST00000617266.2
      Conserved Domains (3) summary
      COG5048
      Location:72 → 303
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:61 → 81
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:185 → 210
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001322260.2 → NP_001309189.1  zinc finger protein 79 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), along with variants 2 and 3, encodes isoform b.
      Source sequence(s)
      AL445222
      Consensus CDS
      CCDS69664.1
      UniProtKB/TrEMBL
      F5H032
      Conserved Domains (4) summary
      COG5048
      Location:182 → 413
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:171 → 191
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:435 → 460
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:16 → 74
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    5. NM_007135.3 → NP_009066.2  zinc finger protein 79 isoform a

      See identical proteins and their annotated locations for NP_009066.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AI301044, AK054606, BC062309, BP351823
      Consensus CDS
      CCDS6871.1
      UniProtKB/Swiss-Prot
      Q15937, Q5VVW1, Q96NV1
      Related
      ENSP00000362446.4, ENST00000342483.5
      Conserved Domains (5) summary
      cd07765
      Location:40 → 77
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:40 → 98
      KRAB; krueppel associated box
      COG5048
      Location:206 → 437
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:195 → 215
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:319 → 344
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      127424382..127445372
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717279.4 → XP_006717342.1  zinc finger protein 79 isoform X1

      See identical proteins and their annotated locations for XP_006717342.1

      UniProtKB/TrEMBL
      F5H032
      Conserved Domains (4) summary
      COG5048
      Location:182 → 413
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:171 → 191
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:435 → 460
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:16 → 74
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      139631324..139652321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363759.1 → XP_054219734.1  zinc finger protein 79 isoform X1

      UniProtKB/TrEMBL
      B4DY65
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15937.2 GenPept UniProtKB/Swiss-Prot:Q15937

    Gene LinkOut

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